2011
DOI: 10.1016/j.cellsig.2011.01.007
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Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling

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Cited by 87 publications
(75 citation statements)
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References 56 publications
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“…Consistent with our observations, previous studies have shown that acyl-deficient Wnt proteins ineffectively initiate Wnt/β-catenin signaling activity in cultured mammalian cells. 21,22 Furthermore, as in the case of deleting β-catenin in the epidermis or inhibiting the Wnt/β-catenin pathway by overexpressing Dkk1, it converts hair follicles into interfollicular epidermis. 47 The function of modulating Wnt/β-catenin signaling activity may also indicate a notable and distinct role of RARRES3 in the cell fate decision.…”
Section: Discussionmentioning
confidence: 99%
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“…Consistent with our observations, previous studies have shown that acyl-deficient Wnt proteins ineffectively initiate Wnt/β-catenin signaling activity in cultured mammalian cells. 21,22 Furthermore, as in the case of deleting β-catenin in the epidermis or inhibiting the Wnt/β-catenin pathway by overexpressing Dkk1, it converts hair follicles into interfollicular epidermis. 47 The function of modulating Wnt/β-catenin signaling activity may also indicate a notable and distinct role of RARRES3 in the cell fate decision.…”
Section: Discussionmentioning
confidence: 99%
“…10,46 Acyl modification of Wnt proteins was also shown to have a crucial role for proteins exiting from the endoplasmic reticulum, secreting to the extracellular domain or binding to the receptor. 21,22 Thus a regulatory mechanism of protein acylation may be necessary for cells to control Wnt/β-catenin signaling activity. In this study, we demonstrate that RARRES3 interacts with and mediates the protein deacylation of Wnt/β-catenin signaling molecules.…”
Section: Discussionmentioning
confidence: 99%
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“…The techniques were performed as described previously (Doubravska et al ., 2011; Waaler et al ., 2012). For immunohistochemistry, dissected intestines were washed in ice‐cold PBS, fixed overnight in 4% (v/v) formaldehyde (Penta) and embedded in paraffin.…”
Section: Methodsmentioning
confidence: 99%
“…2B). To verify these results in a different cell type, the b-catenin stabilization was visualized in L cells (15). In these mouse fibroblasts, monensin reduced Wnt3a-mediated accumulation of b-catenin in the cytoplasm and nucleus (Fig.…”
Section: Monensin Inhibits the Wnt Signaling Cascade At Multiple Levelsmentioning
confidence: 99%