Fatty acid mediators and the inflammasome

Desmarais, Frédérik; Bergeron, Karl-F.; Ntambi, James M.; Rassart, Éric; Mounier, Cathérine

doi:10.1016/b978-0-12-819404-1.00011-7

Cited by 1 publication

(2 citation statements)

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“…Of great interest, ApoD's preferentially binds the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid (ARA) [23,24], the main precursor of many bioactive lipids that are used as signaling molecules, with several being implicated in the inflammatory responses [65].…”

Section: The Main Apod Ligand: Arachidonic Acidmentioning

confidence: 99%

“…However, oxidation of biomolecules is not always deleterious and is sometimes used to produce bioactive molecules of various functions. For example, thiol-containing proteins sometimes require redox reactions to ensure correct protein folding in the ER via protein disulfide isomerase [81], while oxidation of the omega-3 fatty acids docosahexaenoic acid (DHA), docosapentaenoic (DPA) or eicosapentaenoic acid (EPA) by the LOX enzymes give rise to the anti-inflammatory lipid mediators called resolvins, protectins and maresins [65,82].…”

Section: Role Of Apolipoprotein D In Oxidative Stressmentioning

confidence: 99%

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Apolipoprotein D in Oxidative Stress and Inflammation

et al. 2023

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Apolipoprotein D (ApoD) is lipocalin able to bind hydrophobic ligands. The APOD gene is upregulated in a number of pathologies, including Alzheimer’s disease, Parkinson’s disease, cancer, and hypothyroidism. Upregulation of ApoD is linked to decreased oxidative stress and inflammation in several models, including humans, mice, Drosophila melanogaster and plants. Studies suggest that the mechanism through which ApoD modulates oxidative stress and regulate inflammation is via its capacity to bind arachidonic acid (ARA). This polyunsaturated omega-6 fatty acid can be metabolised to generate large variety of pro-inflammatory mediators. ApoD serves as a sequester, blocking and/or altering arachidonic metabolism. In recent studies of diet-induced obesity, ApoD has been shown to modulate lipid mediators derived from ARA, but also from eicosapentaenoic acid and docosahexaenoic acid in an anti-inflammatory way. High levels of ApoD have also been linked to better metabolic health and inflammatory state in the round ligament of morbidly obese women. Since ApoD expression is upregulated in numerous diseases, it might serve as a therapeutic agent against pathologies aggravated by OS and inflammation such as many obesity comorbidities. This review will present the most recent findings underlying the central role of ApoD in the modulation of both OS and inflammation.

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Section: The Main Apod Ligand: Arachidonic Acidmentioning

confidence: 99%