Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance

Sjögren, Per; Sierra‐Johnson, Justo; Gertow, Karl; Rosell, Magdalena; Vessby, Bengt; Fairé, Ulf dé; Hamsten, Anders; Hellénius, Mai Lis; Fisher, Rachel M.

doi:10.1007/s00125-007-0876-9

Cited by 153 publications

(141 citation statements)

References 27 publications

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“…This is in agreement with the findings of Sjögren et al [16]. We did not, however, see any relationship between adipose tissue SCD expression and adipose tissue or plasma TG or NEFA 16:1 n-7/16:0 and 18:1 n-9/18:0 ratios (TG and NEFA data not shown), which was not in agreement with other studies [15,16]. This discrepancy may be due to the fact that a Western diet contains a high proportion of the FAs 16:0 and 18:1 n-9 [18,24], which would obscure these simple proxy SCD activity ratios in plasma and adipose tissue.…”

Section: Discussionsupporting

confidence: 94%

“…We found a strong correlation between IS and the adipose tissue TG 18:1 n-9/18:0 ratio, but not 16:1 n-7/16:0. This is in agreement with the findings of Sjögren et al [16]. We did not, however, see any relationship between adipose tissue SCD expression and adipose tissue or plasma TG or NEFA 16:1 n-7/16:0 and 18:1 n-9/18:0 ratios (TG and NEFA data not shown), which was not in agreement with other studies [15,16].…”

Section: Discussionsupporting

confidence: 86%

“…1) [16], as follows: 18:0/16:0 (proxy for FA elongase activity); 16:1 n-7/16:0 and 18:1 n-9/18:0 (proxy for SCD activity).…”

Section: Calculations and Statistical Analysismentioning

confidence: 99%

“…Currently there is interest in the expression and effects of the enzyme stearoyl-CoA desaturase (SCD), as reflected in FA ratios in plasma [15] or in adipose tissue [16], in relation to insulin status. SCD is regulated in parallel with the pathway of DNL [17], and is responsible for desaturating palmitic acid (16:0) and stearic acid (18:0) to palmitoleic (16:1 n-7) and oleic acid (18:1 n-9), respectively.…”

Section: Introductionmentioning

confidence: 99%

“…SCD is regulated in parallel with the pathway of DNL [17], and is responsible for desaturating palmitic acid (16:0) and stearic acid (18:0) to palmitoleic (16:1 n-7) and oleic acid (18:1 n-9), respectively. Individuals with a high ratio of 18:1 n-9/18:0 in adipose tissue triacylglycerol (TG) are more likely to be insulin resistant [16]. There is little evidence in the literature linking adipocyte FA composition to cell size in humans, although greater n-6 and n-3 polyunsaturated FA content is associated with smaller adipocytes in subcutaneous adipose tissue [18].…”

Section: Introductionmentioning

confidence: 99%

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Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

et al. 2009

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Aims/hypothesis Previous studies have shown relationships between fatty acid ratios in adipose tissue triacylglycerol (TG), adipocyte size and measures of insulin sensitivity. We hypothesised that variations in adipose tissue de novo lipogenesis (DNL) in relation to adiposity might explain some of these observations. Methods In a cross-sectional study, subcutaneous abdominal adipose tissue biopsies from 59 people were examined in relation to fasting and post-glucose insulin sensitivity. Adipocyte size, TG fatty acid composition and mRNA expression of lipogenic genes were determined. Results We found strong positive relationships between adipose tissue TG content of the fatty acids myristic acid (14:0) and stearic acid (18:0) with insulin sensitivity (HOMA model) (p<0.01 for each), and inverse relationships with adipocyte size (p<0.01, p<0.05, respectively).

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 86%

“…1) [16], as follows: 18:0/16:0 (proxy for FA elongase activity); 16:1 n-7/16:0 and 18:1 n-9/18:0 (proxy for SCD activity).…”

Section: Calculations and Statistical Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

et al. 2009

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Current literature in diabetes

2008

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice

Saín

González

Lavandera

et al. 2015

Euro J Lipid Sci & Tech

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Given that the effects of trans fatty acids (TFA) may be associated with the type of TFA isomer and the proportion of n‐3/n‐6/n‐9 fatty acids (FA), this work aimed to investigate the influence of different oils on the following parameters: content, incorporation, and retention of TFA; conversion of vaccenic acid (VA) to rumenic acid (RA) in different tissues; and hepatic output of TFA by VLDL. Another objective was to assess relative conversion rates of key FA and the potential alteration of FA composition induced by TFA in tissues. Male CF1 mice were fed (30‐days) diets containing 7% olive, corn or rapeseed oils either supplemented with 0.75% of TFA or without added TFA. FA composition of liver, epididymal adipose tissue, gastrocnemius muscle, brain, and serum was assessed. With the exception of the brain, TFAs were incorporated into the analyzed tissues and serum. TFA retention and RA bioconversion from VA depended on the dietary unsaturated FA proportions. The higher levels of hepatic RA in the liver of mice fed an olive oil+TFA diet could be associated with a raised Δ9‐desaturase index. The FA composition of tissues was scarcely modified by the consumption of partially hydrogenated vegetable oils containing similar proportions of t9‐, t10‐, and t11‐18:1. Practical applications: The present study evaluates the interaction of hydrogenated vegetable oils with different edible oils and the impact on the FA profile and, specifically, TFA incorporation and retention in the tissues. Since the characterization of FA present in tissues might be determining the biological effects of edible fats, this study is relevant for elucidation of existing controversial findings associated with the intake of TFA and its effects on human metabolic alterations. The levels of trans fatty acids (TFA) in a particular tissue might be related to different variables including: type and level of the dietary TFA isomer; uptake, metabolization and release from the tissue, and interference with different dietary fatty acids.

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Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance

Cited by 153 publications

References 27 publications

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

Current literature in diabetes

Trans fatty acid retention and conversion rates of fatty acids in tissues depend on dietary fat in mice

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