Fatty acid composition of the diet: impact on serum lipids and atherosclerosis

Zöllner, N.; Tatò, Federico

doi:10.1007/bf00180309

Cited by 39 publications

(20 citation statements)

References 311 publications

(373 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In order to establish the hyperlipidemia model, SD rats are fed with HD recipes for 8 weeks and HD leads to lipid metabolism disorders involving the increase in serum TC, TG and LDL, as well as the decrease in HDL. These changes are major risk factors for cardiovascular disease, such as arterial injury (10,23,24). A previous study has shown that the high cholesterol-facilitated vasoconstriction response and the vascular reactivity to NA in various studies were different (25).…”

Section: Discussionmentioning

confidence: 99%

Improvement of thoracic aortic vasoreactivity by continuous and intermittent exercise in high-fat diet-induced obese rats

Liu

Yang

et al. 2015

Biomedical Reports

View full text Add to dashboard Cite

Abstract. The aim of the present study was to explore the effects of continuous and intermittent exercise on the thoracic aortic vasoreactivity and free radical metabolism in rats fed with a high-fat diet (HD). Sprague-Dawley (SD) rats were randomly divided into four groups (n=8, each group): Conventional diet (CD), HD, HD with continuous exercise (HCE) and HD with intermittent exercise (HIE). HCE rats swam once/day for 90 min; HIE rats performed swimming exercises 3 times/day, 30 min each time with an interval of 4 h. In these two groups, the exercise was conducted 5 days a week for 8 weeks. Rats in the CD and HD groups were fed without swimming training. At the end of the exercise, all the rats were sacrificed and the blood, thoracic aorta and myocardium were collected immediately. The thoracic aortic vasoreactivity, the plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), superoxide dismutase (SOD), malondialdehyde (MDA) and vascular endothelial nitric oxide synthase (eNOS) gene expression were measured. Compared to the control group, in the HD group the enhanced contractile response of the thoracic aortic rings to noradrenaline (NA) was observed (P<0.01). The levels of TC and LDL (P<0.01) were also increased in serum while the HDL level was reduced without statistical significance. In addition, the MDA content was upregulated in the myocardium, but the SOD level decreased (P<0.01). Furthermore, the expression of vascular eNOS mRNA was reduced (P<0.01). However, following the exercise the contraction of the thoracic aorta vascular rings to NA was reduced in the HCE and HIE groups (P<0.01), and the decreased contractile response was more evident in the HIE group compared to the HCE group (P<0.01). Additionally, in the HCE group the level of TG (P<0.01) was decreased, while the HDL (P<0.01) level was increased. Although the reduction of the TC and LDL level was also observed there was no significant difference compared to the HD group. In the HIE group, the TG, TC and LDL were downregulated while the HDL was enhanced (P<0.01). The TC and LDL levels were decreased more than those of the HCE group; however, there was no significant difference in the TG and HDL levels between these two groups; additionally, in these two exercise groups, the MDA level was decreased in the myocardium (P<0.01) while the SOD level was increased (P<0.01). Furthermore, the expression of eNOS was upregulated (P<0.01), but the increase was much more in the HIE group than that in the HCE group. In conclusion, exercise may attenuate the aggravated contraction induced by NA and improve the activity of the thoracic aorta in obese rats, which may be associated with enhanced antioxidant enzyme activity and reduced free radical generating. Additionally, intermittent exercise is better than the continuous exercise in improving the thoracic aorta vasoreactivity.

show abstract

Section: Discussionmentioning

confidence: 99%

Improvement of thoracic aortic vasoreactivity by continuous and intermittent exercise in high-fat diet-induced obese rats

Liu

Yang

et al. 2015

Biomedical Reports

View full text Add to dashboard Cite

show abstract

“…Подовження строку придатності вже сьогодні вирішується впровадженням антиоксидантів [4], найчас-тіше синтетичного походження, але їх можна замінити натуральними. Рослинний жир, який використовують у виробництві цукристих кондитерських виробів є не-збалансованим за жирнокислотним складом [5], проте це теж можна вирішити. Отже розв'язав ці дві пробле-ми, цукристі кондитерські вироби вже сьогодні можуть стати продуктами оздоровчого призначення.…”

Section: вступunclassified

Development of the protein-fatty base of the sugar confectionery for nutrition of the sportsmen

Bochkarev¹,

Папченко²,

Matvieieva³

et al. 2016

TAPR

View full text Add to dashboard Cite

“…Numerous experimental and clinical studies have suggested that the n-3 PUFAs, EPA and DHA, and the n-6 PUFA DGLA have beneficial effects on the development of cardiovascular diseases [10,11], hypertension [21,22] or inflammatory diseases [23]. The n-3 PUFAs, EPA and DHA, as well as the n-6 PUFA DGLA reduce platelet aggregation [24][25][26] and lower blood pressure [12,22,[27][28][29].…”

Section: Discussionmentioning

confidence: 99%

“…Compared with the traditional prostaglandin (PG) F 2· , which is a weak vasoconstrictor, and PGE 2 , which is mainly a vasodilator [4], the isoPs, 8-iso-PGF 2· and 8-iso-PGE 2 are powerful equipotent vasoconstrictors in vivo and in vitro [5][6][7][8][9]. It has been found that eicosapentaenoic acid (EPA; C20: 5, n-3), docosahexaenoic acid (DHA; C22: 6, n-3) and dihomo-Á-linolenic acid (DGLA; C20: 3, n-6) have beneficial effects on the development of cardiovascular diseases [for review see [10][11][12]. The antivasoconstrictor action of these polyunsaturated fatty acids (PUFAs) is one of their beneficial effects in vivo and in vitro [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Influence of Polyunsaturated Fatty Acids on Vasoconstrictions Induced by 8-iso-PGF<sub>2α</sub> and 8-iso-PGE<sub>2</sub>

Sametz¹,

M²,

Juan³

et al. 2000

Pharmacology

View full text Add to dashboard Cite

8-iso-PGF_2α and 8-iso-PGE₂, which are released in vivo by free radical catalyzed peroxidation of arachidonic acid, are equipotent vasoconstrictors in vivo and in vitro. It is assumed that they exert this effect via activation of the thromboxane A₂ (TP) receptor or a TP-receptor-like isoprostane receptor. Increased levels of 8-iso-PGF_2α have been detected in human cardiovascular diseases. It has been found that polyunsaturated fatty acids (PUFAs) have many beneficial effects in cardiovascular diseases, including antivasoconstrictor actions. Therefore, we investigated the influence of perfusions with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and dihomo-γ-linolenic acid (DGLA) at final concentrations of 3 and 30 μmol/l on vasoconstriction induced by 8-iso-PGF_2α, 8-iso-PGE₂ and the thromboxane A₂ mimetic U 46619 in the vasculature of the isolated perfused rabbit ear. Additionally, the effect of indomethacin (final concentration 3 μmol/l) on the effects of the PUFAs was investigated. Our results show that the PUFAs at a concentration of 30 μmol/l caused a significant inhibition of the vasoconstrictions induced by 8-iso-PGF_2α, 8-iso-PGE₂ and U 46619. Furthermore, it can be assumed that a part of the inhibitory effect of DGLA is due to the effect of a cyclooxygenase product, probably PGE₁, because indomethacin reduced the inhibitory effect of DGLA.

show abstract

Fatty acid composition of the diet: impact on serum lipids and atherosclerosis

Cited by 39 publications

References 311 publications

Improvement of thoracic aortic vasoreactivity by continuous and intermittent exercise in high-fat diet-induced obese rats

Improvement of thoracic aortic vasoreactivity by continuous and intermittent exercise in high-fat diet-induced obese rats

Development of the protein-fatty base of the sugar confectionery for nutrition of the sportsmen

Influence of Polyunsaturated Fatty Acids on Vasoconstrictions Induced by 8-iso-PGF<sub>2α</sub> and 8-iso-PGE<sub>2</sub>

Contact Info

Product

Resources

About