Fatty Acid Composition of Macroalgae from Nao Zhou Island

Zhao, Zike; Zhang, Shengqiang; Zhao, Lingjuan

doi:10.1007/s43450-021-00153-6

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…[ 9,10 ] Studies have found that Sch B can inhibit the occurrence and progression of liver cancer, gastric cancer, cervical cancer, lung cancer, osteosarcoma, and other cancers by inhibiting tumor cell proliferation and inducing apoptosis. [ 11–17 ] For example, Sch B can induce apoptosis and inhibit invasion and metastasis of prostate cancer cells through the phosphorylation of PI3K/AKT and STA3/JAK2. [ 18 ] Sch B can affect the proliferation and migration of colorectal cancer cells by induced SMURF2 protein expression and affected SIRT1.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of autophagy enhances the anticancer effect of Schisandrin B on head and neck squamous cell carcinoma

Li,

Tang,

et al. 2023

J Biochem & Molecular Tox

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Head and neck squamous cell carcinoma (HNSCC) is among the most common malignant tumors worldwide and has a poor prognosis. Autophagy regulation has been proposed as a possible treatment option for HNSCC. Schisandrin B (Sch B) exerts anticancer effects by regulating apoptosis and autophagy, but the anticancer effect of Sch B in HNSCC remains unclear. This study aimed to investigate the effects of Sch B on human Cal27 HNSCC cells and to further reveal its potential regulatory mechanisms. The anticancer effect of Sch B was evaluated in vitro by flow cytometry, clonogenic assays, and Western blot analysis. The regulatory mechanism of Sch B‐induced apoptosis and autophagy was further explored by polymerase chain reaction, luciferase assay, and reactive oxygen species (ROS) detection. The results showed that Sch B significantly induced apoptosis and autophagy in Cal27 cells and that inhibition of autophagy enhanced the apoptotic effect of Sch B on Cal27 cells. Additionally, Sch B‐activated autophagy in Cal27 cells was dependent on the nuclear factor‐kappa B (NF‐κB) pathway, and ROS acted as a regulator of the NF‐B pathway. N‐acetylcysteine, a scavenger of ROS, inhibited Sch B‐dependent autophagy via the NF‐κB pathway. Based on the results, Sch B is a potential therapeutic agent for HNSCC and activates the NF‐κB pathway by increasing ROS production, which subsequently promotes autophagy in HNSCC cells. Therefore, the strategy of enhancing the anticancer effect of Sch B by inhibiting autophagy deserves further attention.

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Section: Introductionmentioning

confidence: 99%

Inhibition of autophagy enhances the anticancer effect of Schisandrin B on head and neck squamous cell carcinoma

Li,

Tang,

et al. 2023

J Biochem & Molecular Tox

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Recent advances in biochemistry of marine phaeophyta: chemical analysis, structural studies and applications

Bogolitsyn,

Parshina,

Mamatmyrodov

et al. 2023

Studies in Natural Products Chemistry

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Infesting Seaweeds as a Novel Functional Food: Analysis of Nutrients, Antioxidants and ACE Inhibitory Effects

Brai,

Hasanaj,

Vagaggini

et al. 2024

IJMS

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Globalization and climate change are both contributing to an increase in the number of potentially invasive algae in coastal areas. In terms of biodiversity and financial losses, the invasiveness of algae has become a significant issue in Orbetello Lagoon. Indeed, studies from the Tuscany Regional Agency for Environmental Protection show that the reduction in dissolved oxygen caused by algal diffusion is detrimental to fisheries and biodiversity. Considering that wakame and numerous other potentially invasive seaweeds are consumed as food in Asia, we assess the nutritional and nutraceutical qualities of two potentially invasive seaweeds: Valonia aegagrophila and Chaetomorpha linum. We found that both algae are a valuable source of proteins and essential amino acids. Even if the fat content accounts for less than 2% of the dried weight, its quality is high, due to the presence of unsaturated fatty acids. Both algae are rich in antioxidants pigments and polyphenols, which can be exploited as nutraceuticals. Most importantly, human gastrointestinal digestion increased the quantity of polyphenols and originated secondary metabolites with ACE inhibitory activity. Taken together, our data strongly promote the use of Valonia aegagrophila and Chaetomorpha linum as functional foods, with possible application in the treatment of hypertension and cardiovascular diseases.

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Fatty Acid Composition of Macroalgae from Nao Zhou Island

Cited by 3 publications

References 14 publications

Inhibition of autophagy enhances the anticancer effect of Schisandrin B on head and neck squamous cell carcinoma

Inhibition of autophagy enhances the anticancer effect of Schisandrin B on head and neck squamous cell carcinoma

Recent advances in biochemistry of marine phaeophyta: chemical analysis, structural studies and applications

Infesting Seaweeds as a Novel Functional Food: Analysis of Nutrients, Antioxidants and ACE Inhibitory Effects

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