Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia

Agatha, Gerhard; Häfer, Ralf; Zintl, F

doi:10.1016/s0304-3835(01)00674-7

Cited by 42 publications

(27 citation statements)

References 20 publications

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“…The values are reported in Table 1 and are expressed as percentages of the peak areas relative to the sum of the main FA residues detected by GC. Control values were obtained from a group of 10 children, age-matched with AEDS patients, and these were in agreement with data reported for normal subjects in the recent literature (37)(38)(39)(40). It is known that lipid composition of erythrocytes and lymphocytes in the elderly can vary (41) whereas it does not change consistently in young subjects (42).…”

Section: Resultssupporting

confidence: 86%

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

Ferreri

Angelini

Chatgilialoglu

et al. 2005

Lipids

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The formation of trans FA residues in membrane phospholipids may be due to a free radical-catalyzed isomerization process occurring to the cis unsaturated FA moieties. Radical stress is well documented in inflammatory processes of atopic diseases, but no data are yet available about a possible association with trans FA detected in these patients. We investigated the presence of trans lipid isomers in the erythrocyte and T-lymphocyte membranes of 26 children affected by atopic eczema/dermatitis syndrome (AEDS). Trans lipid isomers were found in both cell membranes, up to a total content of 2.7 and 4.9% of the FA composition, respectively. By using the geometrical trans lipid library derived from in vitro models of thiyl radical-catalyzed isomerization, oleic and arachidonic acid isomers were detected. The statistical significance was evaluated by comparison with an age-matched control group. These results suggest the role of an endogenous free radical isomerization path occurring to membrane unsaturated lipids, complementary to the dietary contribution, which can be involved in the lipid impairment in AEDS. This study contributes to lipidomic research regarding the double bond structure and the influence of a geometrical change of membrane lipids in physiology and diseases.

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Section: Resultssupporting

confidence: 86%

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

Ferreri

Angelini

Chatgilialoglu

et al. 2005

Lipids

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“…5B). A previous study indicated that the proportion of PUFAs including three or more double bonds increased in patients with acute lymphoblastic leukemia (66). These results suggest that genes encoding desaturases and elongases are strictly regulated according to tissues or cell types to control the composition of fatty acids in membranes.…”

Section: From Genomic Information To Chemical Structuresmentioning

confidence: 77%

The repertoire of desaturases and elongases reveals fatty acid variations in 56 eukaryotic genomes

Hashimoto

Yoshizawa

Okuda

et al. 2008

Journal of Lipid Research

162

164

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The repertoire of biosynthetic enzymes found in an organism is an important clue for elucidating the chemical structural variations of various compounds. In the case of fatty acids, it is essential to examine key enzymes that are desaturases and elongases, whose combination determine the range of fatty acid structures. We systematically investigated 56 eukaryotic genomes to obtain 275 desaturase and 265 elongase homologs. Phylogenetic and motif analysis indicated that the desaturases consisted of four functionally distinct subfamilies and the elongases consisted of two subfamilies. From the combination of the subfamilies, we then predicted the ability to synthesize six types of fatty acids. Consequently, we found that the ranges of synthesizable fatty acids were often different even between closely related organisms. The reason is that, as well as diverging into subfamilies, the enzymes have functionally diverged within the individual subfamilies. Finally, we discuss how the adaptation to individual environments and the ability to synthesize specific metabolites provides some explanation for the diversity of enzyme functions. This study provides an example of a potent strategy to bridge the gap from genomic knowledge to chemical

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“…These represent the main monounsaturated fatty acids (MUFAs) of membrane phospholipids, triglycerides, wax esters, and cholesterol esters . The saturated to monounsaturated fatty acid ratio affects membrane phospholipid composition, and alteration in this ratio has been implicated in a variety of disease states, including diabetes, obesity, cardiovascular disease, neurological disease, skin disorders, and cancer [Storlien et al, 1991;Jones et al, 1996;Pan et al, 1994;Pettegrew et al, 2001;Solans et al, 2000;Agatha et al, 2001]. For this reason, the activity of SCD is of physiological importance in normal and disease states.…”

Section: Introductionmentioning

confidence: 99%

Stearoyl‐CoA desaturase: a new therapeutic target of liver steatosis

Dobrzyń

2006

Drug Development Research

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Stearoyl-CoA desaturase (SCD) is the rate limiting enzyme catalyzing the biosynthesis of monounsaturated fatty acids, mainly oleate and palmitoleoate, which are used as substrates for the synthesis of triglycerides, wax esters, cholesterol esters, and phospholipids. Recent studies have shown that SCD1, the main SCD isoform expressed in liver, is a key player in the regulation of lipid metabolism. SCD1 deficient mice have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet-induced obesity and liver steatosis. SCD1 was found to be specifically repressed during leptin-mediated weight loss and leptin-deficient ob/ob mice lacking SCD1 showed markedly reduced adiposity, despite higher food intake. In addition, SCD1 deficiency completely corrects the hypometabolic phenotype and hepatic steatosis of ob/ob mice, and attenuates fasting-induced liver steatosis in peroxisome proliferator-activated receptor-a -deficient mice. Consequently, increased SCD activity has been found in humans and animals which accumulate significant amounts of lipids in liver, whereas SCD1 deficiency ameliorates both high-fat diet induced and genetically induced hepatic steatosis. Much evidence indicates that the direct anti-steatotic effect of SCD1 deficiency stems from increased fatty acid oxidation and reduced lipid synthesis. In this review we discuss our current understanding of the role of SCD1 in regulation of hepatic lipid partitioning and test the hypothesis that pharmacological manipulation of SCD might be of benefit in the treatment of non-alcoholic fatty liver disease. Drug Dev.

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Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia

Cited by 42 publications

References 20 publications

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

The repertoire of desaturases and elongases reveals fatty acid variations in 56 eukaryotic genomes

Stearoyl‐CoA desaturase: a new therapeutic target of liver steatosis

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