Fatty acid composition of diet, cord blood and breast milk in Chinese mothers with different dietary habits

Peng, Yongmei; Zhou, Tingting; Wang, Qin; Liu, Peining; Zhang, Tingyan; Zetterström, Rolf; Strandvik, Birgitta

doi:10.1016/j.plefa.2009.07.004

Cited by 82 publications

(65 citation statements)

References 33 publications

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“…Regardless of the timing of maternal blood sampling, the PUFA level in maternal erythrocytes could predict the umbilical cord blood erythrocyte PUFA level from the viewpoint of individual differences within a population group. However, when attempting to predict erythrocyte PUFA levels in umbilical cord blood, it becomes an indispensable condition that the dietary habits from the period of drawing blood to the time of childbirth remain essentially the same, because it is known that EPA and DHA levels in blood tend to be affected by dietary fish intake [11,13,14]. When we predict PUFA levels in infants using maternal blood sampled during pregnancy, but not at the time of delivery, previous studies reported that PUFA levels in erythrocytes were better than plasma PUFA levels [20].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it has been reported that the erythrocyte DHA composition in Japanese people was 7.0% in less than 35-year-old males [8], 6.4% in 20 to 60-year-old women [9], and 7.9% in middle-aged men and women [10]. It has been widely shown that there is an association between dietary n-3 PUFA intake and n-3 PUFA composition in blood [11,12,13,14]. Lands [15] showed a positive correlation of the percentage of n-3 fatty acids in blood 20- and 22-carbon PUFAs and the daily menu balance values determined by the balance of n-6 and n-3 fatty acids (en%) in food; the daily menu balance value of traditional Japanese foods was highly positioned, next to that of Greenland.…”

Section: Introductionmentioning

confidence: 99%

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Polyunsaturated Fatty Acid Levels in Maternal Erythrocytes of Japanese Women during Pregnancy and after Childbirth

et al. 2017

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Background: The transport of polyunsaturated fatty acids (PUFAs), such as arachidonic acid (ARA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), to the fetus from maternal stores increases depending on the fetal requirements for PUFA during the last trimester of pregnancy. Therefore, maternal blood PUFA changes physiologically with gestational age. However, the changes in PUFA levels in maternal blood erythrocytes during pregnancy and after childbirth have not been fully investigated in a fish-eating population. Objective: To examine the changes of ARA and DHA levels in maternal erythrocytes with the progress of pregnancy and the relationship between maternal and umbilical cord erythrocyte PUFA levels in pregnant Japanese women who habitually eat fish and shellfish. Design: This study was performed as a part of the adjunct study of the Japan Environment and Children’s Study (JECS). The participants were 74 pregnant women. The maternal blood samples were collected at 27, 30, and 36 weeks of pregnancy, and 2 days and 1 month after delivery, and umbilical cord blood was collected at delivery. The fatty acid levels of erythrocytes in these blood samples were determined. Results: ARA and DHA levels in maternal erythrocytes tended to decrease with the progress of pregnancy. While the DHA level decreased further after delivery, the ARA level returned to the value at 27 weeks of pregnancy within 1 month after delivery. The n-3 and n-6 PUFA levels in maternal erythrocytes at 27, 30, and 36 weeks of pregnancy were significantly positively correlated with the corresponding fatty acid levels in umbilical cord erythrocytes. Conclusion: The present findings showed a significant change in erythrocyte PUFA levels during pregnancy and after childbirth in a fish-eating population. The PUFA levels of maternal blood after the second trimester may be a reliable marker for predicting PUFA levels in infants’ circulating blood.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acid Levels in Maternal Erythrocytes of Japanese Women during Pregnancy and after Childbirth

et al. 2017

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“…The controversial differences in TC, HDL-C, and LDL-C levels might be because the grouping of previous studies was distinct from ours, and we did not distinguish between IUGR and SGA. Additionally, cord serum lipids might be affected by maternal nutrition and lifestyle [31], which were not evaluated in this study.…”

Section: Discussionmentioning

confidence: 99%

Cord Blood C-peptide, Insulin, HbA1c, and Lipids Levels in Small- and Large-for-Gestational-Age Newborns

et al. 2014

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BackgroundSmall- and large-for-gestational-age (SGA, LGA) newborns are associated with metabolic syndrome in their later life. Cord blood C-peptide, insulin, glycosylated hemoglobin (HbA1c), and lipids levels may be altered in SGA and LGA newborns; however, the results are conflicting. Therefore, this study aimed to determine the effect of cord blood markers on SGA and LGA newborns.Material/MethodsThis was a prospective cohort study and included 2873 term newborns of non-diabetic women. Among these newborns, 83 (2.9%) were SGA, 2236 (77.8%) were appropriate-for-gestational-age (AGA), and 554 (19.3%) were LGA newborns. Cord blood C-peptide, insulin, HbA1c, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured. The chi-square, Kruskal-Wallis, and Mann-Whitney tests were used to analyze categorical variables and continuous variables, respectively. Multinomial logistic regression analysis was used to determine the independent effect of these variables on SGA and LGA newborns.ResultsCord serum TG level was significantly higher in the SGA group than in AGA and LGA groups (p<0.05). The LGA group had significantly higher cord serum insulin level than AGA and SGA groups (p<0.05). After adjustment for confounding variables, including maternal age, parity, pre-pregnancy body mass index (BMI), education, annual household income, pregnancy-induced hypertension (PIH), mode of delivery, and newborn sex, high TG and insulin levels remained significantly associated with SGA and LGA newborns, respectively (p<0.05).ConclusionsHigh cord serum TG and insulin levels are independently associated with SGA and LGA newborns, respectively.

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“…Some countries have reported lower levels of DHA in breast milk, e.g. 0.23% in Nepal [148], and 0.30% in Bangladesh [147], whereas higher DHA levels than the approximately 0.3% typically found in breast milk in Western countries [149] were reported in the Philippines (0.74 ± 0.05%) and a coastal area of Southeastern China (0.61 ± 0.46%) [150] and about 1% was reported in Japan [151]. These data reflect that the DHA content in human milk directly responds to the maternal dietary DHA intake [47].…”

Section: Recent Recommendations On Pre- and Postnatal Lc-pufa Supplymentioning

confidence: 99%

Current Information and Asian Perspectives on Long-Chain Polyunsaturated Fatty Acids in Pregnancy, Lactation, and Infancy: Systematic Review and Practice Recommendations from an Early Nutrition Academy Workshop

et al. 2014

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The Early Nutrition Academy supported a systematic review of human studies on the roles of pre- and postnatal long-chain polyunsaturated fatty acids (LC-PUFA) published from 2008 to 2013 and an expert workshop that reviewed the information and developed recommendations, considering particularly Asian populations. An increased supply of n-3 LC-PUFA during pregnancy reduces the risk of preterm birth before 34 weeks of gestation. Pregnant women should achieve an additional supply ≥200 mg docosahexaenic acid (DHA)/day, usually achieving a total intake ≥300 mg DHA/day. Higher intakes (600-800 mg DHA/day) may provide greater protection against early preterm birth. Some studies indicate beneficial effects of pre- and postnatal DHA supply on child neurodevelopment and allergy risk. Breast-feeding is the best choice for infants. Breast-feeding women should get ≥200 mg DHA/day to achieve a human milk DHA content of ∼0.3% fatty acids. Infant formula for term infants should contain DHA and arachidonic acid (AA) to provide 100 mg DHA/day and 140 mg AA/day. A supply of 100 mg DHA/day should continue during the second half of infancy. We do not provide quantitative advice on AA levels in follow-on formula fed after the introduction of complimentary feeding due to a lack of sufficient data and considerable variation in the AA amounts provided by complimentary foods. Reasonable intakes for very-low-birth weight infants are 18-60 mg/kg/day DHA and 18-45 mg/kg/day AA, while higher intakes (55-60 mg/kg/day DHA, ∼1% fatty acids; 35-45 mg/kg/day AA, ∼0.6-0.75%) appear preferable. Research on the requirements and effects of LC-PUFA during pregnancy, lactation, and early childhood should continue.

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Fatty acid composition of diet, cord blood and breast milk in Chinese mothers with different dietary habits

Cited by 82 publications

References 33 publications

Polyunsaturated Fatty Acid Levels in Maternal Erythrocytes of Japanese Women during Pregnancy and after Childbirth

Polyunsaturated Fatty Acid Levels in Maternal Erythrocytes of Japanese Women during Pregnancy and after Childbirth

Cord Blood C-peptide, Insulin, HbA1c, and Lipids Levels in Small- and Large-for-Gestational-Age Newborns

Current Information and Asian Perspectives on Long-Chain Polyunsaturated Fatty Acids in Pregnancy, Lactation, and Infancy: Systematic Review and Practice Recommendations from an Early Nutrition Academy Workshop

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