Fatty acid composition of adipose tissue in normal, atherosclerotic and diabetic subjects

Alteration of fatty acid metabolism in the liver, adipose tissue, and testis of male mice conceived through assisted reproductive technologies: fatty acid metabolism in ART mice

“…The decrease of PUFAs mainly resulted from C18:2n-6. Antonini FM, Bucalossi A, Petruzzi E, Simoni R, Morini PL and D'Alessandro A [45] have reported that the fatty acid composition of adipose tissue was associated with atherosclerosis and diabetes. Compared to normal people, men with atherosclerosis had lower levels of C18:2n-6 in their adipose tissue.…”

Abnormal fatty acid composition and human atherosclerosis

“…Since these factors include several currently associated with human atherosclerosis the question Introduction A reduced concentration of linoleic acid in the plasma cholesteryl esters is one biochemical abnormality found in patients with ischaemic heart disease (Lewis, 1958), or aorto-iliac/femoro-popliteal atherosclerosis (Schrade, Boehle and Biegler, 1960;Kingsbury et al, 1962b). It also occurred in the depot fats of similar patients (Kingsbury et al, 1962b;Antonini et al, 1969). Since the depot fat composition varied little with the site sampled (Kingsbury et al, 1961' Heffernan, 1963, it appeared that these patients had a widespread reduction oflinoleic acid in their body fats.…”

Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice

“…Human SCD is repressed in cultured cells by polyunsaturated fatty acids and cholesterol via sterol-regulatory element binding protein-1 (SREBP-1) (15). Furthermore, SCD mRNA is increased in skeletal muscle of obese humans (16), and several but not all (17) observational studies in humans have shown an association between increased indices of SCD activity and components of the metabolic syndrome, including insulin resistance (18)(19)(20)(21), obesity (16,(22)(23)(24), and hypertension (25). The expression of mouse Scd1 in adipose tissue and liver (8,10) and its regulation by the lipogenic transcription factors SREBP-1 and liver X receptor (LXR) (26) define it as the most relevant murine ortholog for studying the metabolic function of SCD activity in humans.…”