Fatty-Acid Composition in Oil of Vinca minor and V. herbaceae Growing in Georgia

Kikalishvili, B; Zurabashvili, D; Turabelidze, D. G.; Sulakvelidze, Ts; Vachnadze, N; Malaniya, M. A.

doi:10.1007/s10600-014-0833-z

Cited by 2 publications

(2 citation statements)

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“…Flaxseed oil (FO) contains up to 50% w-3 PUFAs, of which a-linolenic acid is converted to eicosapentaenoic and docosahexaenoic acids in mammals (4). In addition, w-3 PUFAs contain stearic, oleic, linoleic and palmitic acids, and phenolic compounds, all of which have important roles in spermatogenesis and antioxidant enzyme activity (5).…”

Section: Introductionmentioning

confidence: 99%

Dietary flaxseed oil and vitamin E improve semen quality via propionic acid metabolism

et al. 2023

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IntroductionFlaxseed oil (FO) and vitamin E (VE) both have antioxidant effects on sperm. The present study investigated the effects of dietary supplementation with FO and/or VE on semen quality.Methods16 fertile Simmental bulls were selected and randomly divided into 4 groups (n = 4): the control group (control diet), FO group (control diet containing 24 g/kg FO), VE group (control diet containing 150 mg/kg VE) and FOVE group (control diet containing 150 mg/kg VE and 24 g/kg FO), and the trial lasted 10 weeks.ResultsThe results showed that the addition of FO independently can increase sperm motion parameters, the levels of catalase (CAT), glutathione peroxidase (GSH-Px), testosterone (T) and estradiol (E2), while reduce oxidative stress in seminal plasma (P < 0.05). Supplement of VE independently can increased the motility, motility parameters, CAT and superoxide dismutase (SOD) levels, and reduce oxidative stress in seminal plasma (P < 0.05). There was an interaction effect of FO × VE on motility and reactive oxygen species (ROS), while GSH-Px and ROS were affected by week × VE 2-way interaction, levels of T and E2 were also affected by the dietary FO × week interaction (P < 0.05). The triple interaction effects of FO, VE and week were significant for malondialdehyde (MDA) (P < 0.05). Compared with the control group, sperm from the FOVE group had a significantly higher in vitro fertilization (IVF) rate, and subsequent embryos had increased developmental ability with reduced ROS levels at the eight-cell stage, then increased adenosine triphosphate (ATP) content and gene expression levels of CAT, CDX2, Nanog, and SOD at the blastocyst stage (P < 0.05). Metabolomic and transcriptomic results indicated that dietary supplementation of FO and VE increased the expression of the metabolite aconitic acid, as well as the expression of ABAT and AHDHA genes.ConclusionWith in-silico analysis, it can be concluded that the effects of dietary FO and VE on improving semen quality and embryo development may be related to increased aconitic acid via the ABAT and AHDHA genes involved in the propionic acid metabolism pathway.

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Section: Introductionmentioning

confidence: 99%

Dietary flaxseed oil and vitamin E improve semen quality via propionic acid metabolism

et al. 2023

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“…Linoleic acid (C18:2) and oleic acid (C18:1) are most important unsaturated fatty acids present in grape seed oil (GSO). 18 Many possible mechanisms have been proposed for the grape seeds' neuroprotective effects such as free radical scavenging via reducing lipid peroxidation, exerting superior antioxidant efficacy, inhibiting DNA oxidative and blocking cell death signaling. 19,20 Grape seed extract demonstrated to be effective on memory remission in beta amyloid induced memory loss, 21 but such a study has not been done on GSO.…”

Section: Introductionmentioning

confidence: 99%

Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer’s Diseases

et al. 2020

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Purpose: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, with an increasing prevalence rate, mostly related to cholinergic system. According to the difficulties and complications in management of AD, this study was carried out to evaluate the efficacy of grape seed oil (GSO) on scopolamine (Scop) induced Alzheimer’s in male rats. Methods: 64 healthy male Wistar rats received different treatments such as: normal saline (NS), donepezil (Don), Scop and GSO, according to the previously designed protocol. Morris (MWM) was applied for spatial memory tests. Right after the behavioral tests, the brains were removed and the hippocampus was separated for evaluation of acetylcholine levels as well as cell death and neuro inflammation. Results: The results of the test day indicated that the mean Q2 time was increased in both GSO test groups (P<0.05) and Don treated group (P<0.001).The spectrophotometric findings affirm that both GSO co-treatment and post-treatment were effective in augmenting brain acetylcholine levels (P<0.01 and P<0.05 respectively). The microscopic findings of Hamp;E dyed tissues confirmed the above mentioned results for different treatments except for GSO post treatment, in which the viability of cells were very low. Conclusion: The results implied that supplementation of rats with GSO caused a significant augmentation in spatial memory performance as well as acetylcholine levels and cell viability in the presence of Scop. This effect was comparable to that of Don especially when GSO was used as co-treatment.

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Fatty-Acid Composition in Oil of Vinca minor and V. herbaceae Growing in Georgia

Cited by 2 publications

References 1 publication

Dietary flaxseed oil and vitamin E improve semen quality via propionic acid metabolism

Dietary flaxseed oil and vitamin E improve semen quality via propionic acid metabolism

Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer’s Diseases

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