“…31 GABA-induced FFAO could also be critical in endothelial cells in the tumor microenvironment, where it has been shown that FFAO is the major source for nucleotide synthesis. 32 Furthermore, GABA could be important in regulating endothelial cell permeability, as it has recently been reported that FFAO has emerged as a central regulator of endothelial cell permeability and blood vessel stability. 33 Administration of GABA markedly attenuated insulitis and systemic inflammation in mice.…”
Section: Discussionmentioning
confidence: 99%
“…[31][32][33] Therefore, we assessed whether GABA promoted fatty acid oxidation in HUVEC. As fatty acid oxidation is critically regulated at the level of its mitochondrial entry, we investigated whether GABA modulated both uptake and subsequent oxidation of fatty acids in HUVEC.…”
Section: Gaba Promoted Mitochondrial Free Fatty Acid Uptake and Oxidamentioning