Fatty Acid-Binding Proteins in Psoriasis—A Review

Abstract

Psoriasis is one of the most common skin diseases in dermatological practice. It affects about 1–3% of the general population and is associated with different comorbidities, especially metabolic syndrome. Fatty-acid-binding proteins (FABPs) are a family of cytosolic proteins which are an important link in lipid metabolism and transport; moreover, they have different tissue specificity and properties. So far, ten FABPs have been discovered and seven have been investigated in psoriasis. In this review, we discuss the nature of all FABPs and their role in psoriasis. FABPs have different organ and tissue expression, and hence various functions, and may be markers of different disorders. Considering the concentration of a few of them tends to be elevated in psoriasis, it confirms the current perception of psoriasis as a multiorgan disorder associated with plenty of comorbidities. Some FABPs may be also further investigated as biomarkers of psoriasis organ complications. FABP-1 and FABP-5 may become potential markers of metabolic complications and inflammation in psoriasis. FABP-7 could perhaps be further investigated as an indicator of the neurodegenerative processes in psoriatic patients.

Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis

“…This indicates the upregulated biosynthesis and recruitment of such species at the lesional sites, where they may play the role as signal transducers and are also required to prevent epidermal water loss . Previous studies have reported an increased activity of the epidermal form of fatty acid-binding protein (FABP) in dermatitis and other skin disorders. , Since FABP preferentially binds to saturated fatty acids, this could contribute to a lower traffic of unsaturated FFAs at v2 when compared to v10. Other proteins supporting beta-oxidation are known to be overexpressed in skin diseases, i.e., carnitine palmitoyltransferase-1 (CPT-1) and peroxisomal fatty acyl-CoA oxidase (ACOX1). , This is congruent with the carbon chain shortening lipid profile observed in the present study, indicating that beta-oxidation may be an important source of energy for supplying the intensified and continuous cell growth in lesional skin.…”

“…88 Previous studies have reported an increased activity of the epidermal form of fatty acid-binding protein (FABP) in dermatitis and other skin disorders. 89,90 Since FABP preferentially binds to saturated fatty acids, 91 this could contribute to a lower traffic of unsaturated FFAs at v2 when compared to v10. Other proteins supporting beta-oxidation are known to be overexpressed in skin diseases, i.e., carnitine palmitoyltransferase-1 (CPT-1) and peroxisomal fatty acyl-CoA oxidase (ACOX1).…”

Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds

“…S 3 G). The CD36 protein, located on various cell membranes, transports fatty acids in response to dietary fat [ 153 ], while FABP5 expression is most prominent in the epidermis and considered a transporting and binding agent for lipid homeostasis [ 154 ]. These results demonstrated that the muscular differences in lipid metabolism, probably linked to pig breed, were associated primarily with the physiological functions of epithelium in TG-rich lipoprotein hydrolysis and FFA absorption.…”

The clinical indicators predicting the efficacy of acitretin in the treatment of psoriasis

“…It has been reported that acitretin binds very tightly to plasma albumin (91% of plasma acitretin), with a binding constant of 0.7× l0 6 M − 1 23 . This study speculates that serum Alb levels may affect acitretin absorption, as acitretin achieved better e cacy with increasing serum Alb levels.…”