Fatty acid binding proteins in multiple myeloma

Diedrich, Camila; Maksimos, Mina; Azab, Abdel Kareem

doi:10.1016/j.molmed.2023.05.011

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Lipid Metabolic Vulnerabilities Of MM1

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2023

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“…Recently, a role of fatty acid binding proteins (FABPs) in contributing to cancer development and progression has emerged [ 85 – 87 ]. FABPs facilitate the long-chain FAs intracellular trafficking and regulate FA synthesis and β-oxidation [ 86 ].…”

Section: Lipid Metabolic Vulnerabilities Of MMmentioning

confidence: 99%

Lipid metabolic vulnerabilities of multiple myeloma

Torcasio,

Gallo Cantafio,

Ikeda

et al. 2023

Clin Exp Med

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Multiple myeloma (MM) is the second most common hematological malignancy worldwide, characterized by abnormal proliferation of malignant plasma cells within a tumor-permissive bone marrow microenvironment. Metabolic dysfunctions are emerging as key determinants in the pathobiology of MM. In this review, we highlight the metabolic features of MM, showing how alterations in various lipid pathways, mainly involving fatty acids, cholesterol and sphingolipids, affect the growth, survival and drug responsiveness of MM cells, as well as their cross-talk with other cellular components of the tumor microenvironment. These findings will provide a new path to understanding the mechanisms underlying how lipid vulnerabilities may arise and affect the phenotype of malignant plasma cells, highlighting novel druggable pathways with a significant impact on the management of MM.

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Section: Lipid Metabolic Vulnerabilities Of MMmentioning

confidence: 99%