Fatty Acid Binding Protein as an Early Plasma Marker of Myocardial Ischemia and Risk Stratification

Glatz, Jan F. C.; Putten, Roy F. M. van der; Hermens, Wim Th.

doi:10.1007/978-1-59259-385-9_20

Cited by 2 publications

(4 citation statements)

References 77 publications

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“…In another study in a department of cardiology, H-FABP at the third hour was found to be the most sensitive marker after troponin T. In this study, the sensitivity, specificity and NPV of H-FABP at the third hour were 96.4%, 100% and 95.5%, respectively, while the sensitivity, specificity and the NPV of troponin T were all 100%. 17 In the present study, although the sensitivity of H-FABP was higher than that of troponin I at admission, the sensitivity of 4 Factors that disrupt the perception of pain, such as chronic illnesses, diabetes mellitus or patientspecific factors, and late presentation of patients to the hospital, may cause low diagnostic values of H-FABP at the third and sixth hours.…”

Section: Discussioncontrasting

confidence: 48%

“…4 Recent studies have shown that H-FABP is a useful marker for excluding acute coronary syndromes (ACS) or making a rapid acute coronary syndrome diagnosis. 2,[4][5][6] The routine use of H-FABP in clinics may shorten patient follow-up periods and save monetary resources. The aim of this study was to evaluate the diagnostic value of H-FABP as an early marker of AMI at 0, 3 and 6 hours after admission.…”

Section: Introductionmentioning

confidence: 99%

“…Peak measurements can be obtained at 6-8 hours, and values return to normal limits 24-30 hours post-cardiac injury. 4 Recent studies have shown that H-FABP is a useful marker for excluding acute coronary syndromes (ACS) or making a rapid acute coronary syndrome diagnosis. 2,[4][5][6] The routine use of H-FABP in clinics may shorten patient follow-up periods and save monetary resources.…”

Section: Introductionmentioning

confidence: 99%

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Serial Measurement of Heart-Type Fatty Acid Binding Protein for the Rapid Diagnosis of Acute Coronary Syndromes in the Emergency Department

Limon¹,

Atilla

Oray

et al. 2014

Hong Kong Journal of Emergency Medicine

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Introduction We aimed to investigate the diagnostic accuracy of heart-type fatty acid binding protein (H-FABP) at admission and the third and sixth hour after admission in patients presenting to the emergency department (ED) with chest pain or equivalent symptoms. Methods This prospective study was performed over two months in the ED. Patients presenting with ischaemic-type chest pain or other symptoms suggestive of myocardial ischaemia were included in the study. A bedside, point-of-care, quantitative H-FABP level was measured. If the initial electrocardiography (ECG) was non-diagnostic, the patients were observed for six hours. During the observation period, serial H-FABP measurements were obtained at admission, the third hour and the sixth hour; serial measurements of total creatine kinase (CK), CK-MB, troponin I and myoglobin were recorded at admission and the sixth hour. Results A total of 183 patients were included in the study. Initial H-FABP was measured in a joint group of ST segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI) patients, with a sensitivity of 80.9%, specificity of 19.2%, positive predictive value (PPV) of 23% and negative predictive value (NPV) of 77.1%. The third-hour H-FABP was measured in the NSTEMI group, with a sensitivity of 46.7%, specificity of 80.2%, PPV of 42.4% and NPV of 82.6%. The sixth-hour H-FABP had a sensitivity of 33.3%, specificity of 73.9%, PPV of 24.2% and NPV of 81.5%. Conclusion H-FABP is superior to myoglobin for diagnosing myocardial infarction in a joint group of STEMI and NSTEMI patients. The third-hour NPV value for H-FABP indicates that, for safety considerations, the cardiac observation time should not be shortened. (Hong Kong j.emerg.med. 2014;21:213-221)

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Section: Discussioncontrasting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serial Measurement of Heart-Type Fatty Acid Binding Protein for the Rapid Diagnosis of Acute Coronary Syndromes in the Emergency Department

Limon¹,

Atilla

Oray

et al. 2014

Hong Kong Journal of Emergency Medicine

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“…Protein markers of myocardial injury are commonly used in the diagnosis of ACS but even for the earliest marker of cardiomyocyte death, fatty acid-binding protein (FABP), it takes several hours until elevations in its plasma level become detectable (Glatz et al, 2003). As coronary thrombosis occurs prior to cell death and protein release, markers of activated blood coagulation could appear earlier and thereby close this diagnostic gap.…”

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confidence: 99%

State and diagnostic value of plasma tissue factor in early‐hospitalised patients with chest pain

et al. 2005

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SummaryTo study the state and diagnostic value of plasma tissue factor (TF) in patients with acute coronary syndromes (ACS), we quantitatively compared plasma TF antigen and TF activity in 90 early-hospitalised patients with chest pain. Using high-affinity antibodies, a sensitive assay for TF antigen was developed with a detection limit of 40 fmol/l. One of the antibodies was used to capture TF from plasma and, after elution and dialysis-free reconstitution in phospholipid-glucoside micelles, absolute amounts of TF activity could be measured with a detection limit of 80 fmol/l. All TF in plasma was found to be exposed, and a value of 2AE5(1AE1-14AE8) pmol/l (median with range) was found for TF antigen. Most of this TF antigen (70-80%) circulated in a (potentially) functional state. Left in its in vivo state, however, TF captured from plasma was totally inactive, probably because of the lack of a procoagulant matrix. Compared with controls with non-cardiac chest pain, TF activity was unchanged and TF antigen about 25% elevated in ACS patients. Combined with the markers prothrombin fragment F1+2 and fatty acid-binding protein, TF did not improve the early diagnosis of ACS.

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Fatty Acid Binding Protein as an Early Plasma Marker of Myocardial Ischemia and Risk Stratification

Cited by 2 publications

References 77 publications

Serial Measurement of Heart-Type Fatty Acid Binding Protein for the Rapid Diagnosis of Acute Coronary Syndromes in the Emergency Department

Serial Measurement of Heart-Type Fatty Acid Binding Protein for the Rapid Diagnosis of Acute Coronary Syndromes in the Emergency Department

State and diagnostic value of plasma tissue factor in early‐hospitalised patients with chest pain

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