Fatty acid‑binding protein 5 predicts poor prognosis in patients with uveal melanoma

Xu, Wenhao; Yang, Xiaolong; Zhang, Hai‑Liang; Zhang, Xiaofeng

doi:10.3892/ol.2020.11301

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…These findings also suggest that FABP5 could be considered as a prognostic indicator and a target for therapeutic agents. Similar conclusions were derived from a study of patients with uveal melanoma confirming that FABP5 is associated with progression of some types of tumor and can be considered a prognostic marker (Xu et al 2020 ).…”

Section: Fabp Chaperonopathiessupporting

confidence: 77%

Lipid chaperones and associated diseases: a group of chaperonopathies defining a new nosological entity with implications for medical research and practice

D’Anneo

Bavisotto

Gammazza

et al. 2020

Cell Stress and Chaperones

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Fatty acid–binding proteins (FABPs) are lipid chaperones assisting in the trafficking of long-chain fatty acids with functions in various cell compartments, including oxidation, signaling, gene-transcription regulation, and storage. The various known FABP isoforms display distinctive tissue distribution, but some are active in more than one tissue. Quantitative and/or qualitative changes of FABPs are associated with pathological conditions. Increased circulating levels of FABPs are biomarkers of disorders such as obesity, insulin resistance, cardiovascular disease, and cancer. Deregulated expression and malfunction of FABPs can result from genetic alterations or posttranslational modifications and can be pathogenic. We have assembled the disorders with abnormal FABPs as chaperonopathies in a distinct nosological entity. This entity is similar but separate from that encompassing the chaperonopathies pertaining to protein chaperones. In this review, we discuss the role of FABPs in the pathogenesis of metabolic syndrome, cancer, and neurological diseases. We highlight the opportunities for improving diagnosis and treatment that open by encompassing all these pathological conditions within of a coherent nosological group, focusing on abnormal lipid chaperones as biomarkers of disease and etiological-pathogenic factors.

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Section: Fabp Chaperonopathiessupporting

confidence: 77%

Lipid chaperones and associated diseases: a group of chaperonopathies defining a new nosological entity with implications for medical research and practice

D’Anneo

Bavisotto

Gammazza

et al. 2020

Cell Stress and Chaperones

View full text Add to dashboard Cite

show abstract

“…The inhibition of C5AR1 expression in squamous cell carcinoma can promote intratumoral CD8 + T cell infiltration ( Medler et al, 2018 ). Fatty Acid Binding Protein 5 (FABP5) is highly correlated with complement signaling in uveal melanoma, and it promotes CD8 + T cell infiltration ( Xu et al, 2020 ). C3 knockout mice-bearing lung cancer exhibited increased numbers of CD8 + T cells and decreased tumor growth ( Kwak et al, 2018 ).…”

Section: The Complement Pathways In Glioma Microenvironmentsmentioning

confidence: 99%

Targeting the Complement Pathway in Malignant Glioma Microenvironments

Zhu

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Malignant glioma is a highly fatal type of brain tumor, and its reoccurrence is largely due to the ordered interactions among the components present in the complex microenvironment. Besides its role in immune surveillance and clearance under physiological conditions, the complement system is expressed in a variety of tumor types and mediates the interactions within the tumor microenvironments. Recent studies have uncovered the broad expression spectrum of complement signaling molecules in the tumor microenvironment and various tumor cells, in particular, malignant glioma cells. Involvement of the complement system in tumor growth, immunosuppression and phenotype transition have also been elucidated. In this review, we enumerate the expression and function of complement molecules in multiple tumor types reported. Moreover, we elaborate the complement pathways in glioma cells and various components of malignant glioma microenvironments. Finally, we summarize the possibility of the complement molecules as prognostic factors and therapeutic targets in the treatment of malignant glioma. Specific targeting of the complement system maybe of great significance and value in the future treatment of multi-type tumors including malignant glioma.

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Oncogenic role and potential regulatory mechanism of fatty acid binding protein 5 based on a pan-cancer analysis

Wang

Zhao

Sun

et al. 2023

Sci Rep

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As one member of fatty acid binding proteins (FABPs), FABP5 makes a contribution in the occurrence and development of several tumor types, but existing analysis about FABP5 and FABP5-related molecular mechanism remains limited. Meanwhile, some tumor patients showed limited response rates to current immunotherapy, and more potential targets need to be explored for the improvement of immunotherapy. In this study, we made a pan-cancer analysis of FABP5 based on the clinical data from The Cancer Genome Atlas database for the first time. FABP5 overexpression was observed in many tumor types, and was statistically associated with poor prognosis of several tumor types. Additionally, we further explored FABP5-related miRNAs and corresponding lncRNAs. Then, miR-577-FABP5 regulatory network in kidney renal clear cell carcinoma as well as CD27-AS1/GUSBP11/SNHG16/TTC28-AS1-miR-22-3p-FABP5 competing endogenous RNA regulatory network in liver hepatocellular carcinoma were constructed. Meanwhile, Western Blot and reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) analysis were used to verify miR-22-3p-FABP5 relationship in LIHC cell lines. Moreover, the potential relationships of FABP5 with immune infiltration and six immune checkpoints (CD274, CTLA4, HAVCR2, LAG3, PDCD1 and TIGIT) were discovered. Our work not only deepens the understanding of FABP5’s functions in multiple tumors and supplements existing FABP5-related mechanisms, but also provides more possibilities for immunotherapy.

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Fatty acid‑binding protein 5 predicts poor prognosis in patients with uveal melanoma

Cited by 4 publications

References 46 publications

Lipid chaperones and associated diseases: a group of chaperonopathies defining a new nosological entity with implications for medical research and practice

Lipid chaperones and associated diseases: a group of chaperonopathies defining a new nosological entity with implications for medical research and practice

Targeting the Complement Pathway in Malignant Glioma Microenvironments

Oncogenic role and potential regulatory mechanism of fatty acid binding protein 5 based on a pan-cancer analysis

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