Fatty acid‐binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung

Yang, Shuhan; Kobayashi, Shuhei; Sekino, Kaname; Kagawa, Yoshiteru; Miyazaki, Hirofumi; Shil, Subrata Kumar; Umaru, Banlanjo Abdulaziz; Wannakul, Tunyanat; Owada, Yuji

doi:10.1002/1873-3468.14106

Cited by 16 publications

(10 citation statements)

References 35 publications

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“…The scRNA-seq results show that only FABP3/4/5/7, and a very small amount of FABP6, are expressed in NSCLC. In this malignancy, FABP5 was reported to facilitate tumorigenesis and metastasis [ 52 , 53 ], while the functions of FABP3 and 4 are less clear and even become controversial [ 54 ], and the role of FABP6 and 7 remain unclarified in NSCLC. In fact, our work firstly reports the pro-metastatic function of FABP7 in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation

Bai

Yang

et al. 2022

Cells

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Metastasis accounts for 90% of cancer-related deaths and represents a prominent malignant feature in non-small cell lung cancer (NSCLC), while tumor cell-specific mechanisms and molecules pivotal for the metastatic capacity remain unclear. By analyzing single-cell RNA sequencing data, we found that fatty acid binding protein 7 (FABP7) was specifically up-regulated in tumor cells of metastatic NSCLC patients and might be a prognostic indicator for poor survival. Experimental studies based on NSCLC cell lines showed that FABP7 promoted the metastatic competencies of NSCLC cells in vitro and in vivo. Mechanistically, we demonstrated that FABP7 was important to canonical Wnt signaling activation and competitively inhibited the interaction between β-catenin and components of its cytoplasmic degradation complex, thereby repressing the phosphorylation-dependent ubiquitination and degradation of β-catenin. Our present study identifies FABP7 as a metastatic tumor cell-specific pro-metastatic gene and uncovers a previously unknown regulatory mechanism underlying Wnt hyperactivation via FABP7-impaired cytoplasmic β-catenin degradation, implicating a novel molecule in regulating NSCLC metastasis.

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Section: Discussionmentioning

confidence: 99%

Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation

Bai

Yang

et al. 2022

Cells

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“…Studies has provided evidences that PSAT1 is elevated in NSCLC. PSAT1 overexpression impairs the prognosis of cancer by promoting cancer cell proliferation, metastasis, as well as chemoresistance discovered that NRF2 regulates the expression of the important serine synthesis enzymes PHGDH, PSAT1, and SHMT2 through the activation of ATF4 to promote glutathione and nucleotide formation [ 114 ]. In response to serine deprivation, ATF4 stimulates serine biosynthesis genes in NSCLC cells [ 115 ].…”

Section: Major Metabolic Pathway Changes Involved In Lung Canermentioning

confidence: 99%

A Systematic Role of Metabolomics, Metabolic Pathways, and Chemical Metabolism in Lung Cancer

et al. 2023

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Lung cancer (LC) is considered as one of the leading causes of cancer-associated mortalities. Cancer cells’ reprogrammed metabolism results in changes in metabolite concentrations, which can be utilized to identify a distinct metabolic pattern or fingerprint for cancer detection or diagnosis. By detecting different metabolic variations in the expression levels of LC patients, this will help and enhance early diagnosis methods as well as new treatment strategies. The majority of patients are identified at advanced stages after undergoing a number of surgical procedures or diagnostic testing, including the invasive procedures. This could be overcome by understanding the mechanism and function of differently regulated metabolites. Significant variations in the metabolites present in the different samples can be analyzed and used as early biomarkers. They could also be used to analyze the specific progression and type as well as stages of cancer type making it easier for the treatment process. The main aim of this review article is to focus on rewired metabolic pathways and the associated metabolite alterations that can be used as diagnostic and therapeutic targets in lung cancer diagnosis as well as treatment strategies.

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“…Reported mechanisms underlying these effects are quite varied and include protein-protein interaction and modulation of HIF-1α ( 153 ) or estrogen-related receptor (ERR)-α ( 152 ), regulation of TNF-α-dependent NF-κB signaling ( 180 ) or PI3 kinase/Akt signaling ( 114 ), and regulation of lipid metabolism ( 18 , 52 ) or of angiogenesis via VEGFA-dependent signaling ( 138 ). It is noteworthy, however, that several reports indicate that inhibition/knockdown of FABP5 could have an opposite effect, resulting in more skin tumors ( 199 ) and increased lung cancer metastases ( 194 ).…”

Section: Fabp5mentioning

confidence: 99%

The Multifunctional Family of Mammalian Fatty Acid–Binding Proteins

Storch

Córsico

2023

Annu. Rev. Nutr.

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Fatty acid–binding proteins (FABPs) are small lipid-binding proteins abundantly expressed in tissues that are highly active in fatty acid (FA) metabolism. Ten mammalian FABPs have been identified, with tissue-specific expression patterns and highly conserved tertiary structures. FABPs were initially studied as intracellular FA transport proteins. Further investigation has demonstrated their participation in lipid metabolism, both directly and via regulation of gene expression, and in signaling within their cells of expression. There is also evidence that they may be secreted and have functional impact via the circulation. It has also been shown that the FABP ligand binding repertoire extends beyond long-chain FAs and that their functional properties also involve participation in systemic metabolism. This article reviews the present understanding of FABP functions and their apparent roles in disease, particularly metabolic and inflammation-related disorders and cancers. Expected final online publication date for the Annual Review of Nutrition, Volume 43 is August 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Fatty acid‐binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung

Cited by 16 publications

References 35 publications

Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation

Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation

A Systematic Role of Metabolomics, Metabolic Pathways, and Chemical Metabolism in Lung Cancer

The Multifunctional Family of Mammalian Fatty Acid–Binding Proteins

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