Fatty acid‐binding protein 3 controls contact hypersensitivity through regulating skin dermal Vγ4⁺ γ/δ T cell in a murine model

Abstract

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Fatty acid‐binding protein 5 limits the generation of Foxp3+ regulatory T cells through regulating plasmacytoid dendritic cell function in the tumor microenvironment

“…Long‐chain fatty acids, including omega‐3 polyunsaturated fatty acids and palmitic acid, have been reported to be involved in epigenetic regulation 40‐43 . Furthermore, we recently revealed that FABP molecules epigenetically regulate immune cell function and differentiation 44,45 . Since it has been suggested that gene expression in DC subsets is also epigenetically regulated, 46 we speculate that FABP5 regulates pDC function epigenetically by binding its ligands, 43,47 especially palmitic acid 48 .…”

“…[40][41][42][43] Furthermore, we recently revealed that FABP molecules epigenetically regulate immune cell function and differentiation. 44,45 Since it has been suggested that gene expression in DC subsets is also epigenetically regulated, 46 we speculate that FABP5 regulates pDC function epigenetically by binding its ligands, 43,47 especially palmitic acid. 48 In this context, it is interesting to note that saturated fatty acids (especially palmitic acid) may be increased in the TME of melanoma.…”

On-Chip Discovery of Allergens from the Exudate of Large Yellow Croaker (Larimichthys Crocea) Muscle Food by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

“…It has been reported that FABP5 and FABP4 have a function in the regulation of skin inflammation and asthma, , implying that FABP molecules may regulate allergic diseases by immune regulation that is linked to lipid metabolism. FABP3 plays a very important role in the immunological function of lymphocytes and additionally has a function in the regulation of allergic diseases …”

“…FABP3 plays a very important role in the immunological function of lymphocytes and additionally has a function in the regulation of allergic diseases. 28 The microsomal glutamate S-transfer 3 (MGST3) is commonly found in vertebrate membrane fragments, such as endoplasmic reticulum, microsomal membranes, etc. It has been found to be related to glutathione S-transferase activity in the skin allergy state of mice.…”

Metabolic regulation of T cell development

“…Fatty acid-binding protein 3 (FABP3) regulates cellular lipid metabolism by binding to polyunsaturated fatty acids (PUFAs), such as ω-6 PUFAs. Recently, it has been shown that loss of FABP3 redirects DN2 thymocytes to pathogenic Vγ4+ γδ T cells ( 46 ). Mitochondrial metabolism also plays a role in thymocyte development.…”