Fatty acid and lipidomic data in normal and tumor colon tissues of rats fed diets with and without fish oil

Djurić, Zora; Aslam, Muhammad N.; Simon, B; Sen, Ananda; Jiang, Yan; Ren, Jianwei; Chan, Rena; Soni, Tanu; Rajendiran, Thekkelnaycke M.; Smith, William L.; Brenner, Dean E.

doi:10.1016/j.dib.2017.06.032

Cited by 2 publications

(6 citation statements)

References 3 publications

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“…These differences between normal and tumor tissue were not significant in rats fed the fish oil diet. The complete fatty acid profiles are shown in the accompanying Data in Brief article [28]. …”

Section: Resultsmentioning

confidence: 99%

“…PC 40:4), as shown in Table 4. More detailed lipodomic data is available in the accompanying Data in Brief article [28]. …”

Section: Resultsmentioning

confidence: 99%

“…After adjusting for false discovery rates, those lipids with p < 0.05 for the effect of diet (fish oil, Western fat) or tissue type (tumor, carcinogen-treated normal or normal) were subjected to principal component analysis using the pca3d package and hierarchical clustering analyses with the R program [25, 26]. Heatmaps were created using function “heatmap.2” in package “gplots” within the R program [27] and are shown in the Data in Brief accompanying article [28]. …”

Section: Methodsmentioning

confidence: 99%

“…All variables were log transformed before analysis. Full fatty acid profiles are shown in the accompanying Data in Brief article [28]. …”

Section: Figurementioning

confidence: 99%

“…^ Marked values differ significantly in tumor or in normal tissue from carcinogen-treated rats versus normal tissue of control rats, within each diet group (p<0.005), from two-way ANOVA. Full fatty acid profiles are shown in the accompanying Data in Brief article [28]. …”

Section: Figurementioning

confidence: 99%

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Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: modulation by the lipogenic phenotype of colon tumors

Djurić

Aslam

Simon

et al. 2017

The Journal of Nutritional Biochemistry

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Dietary fish oils have potential for prevention of colon cancer, and yet the mechanisms of action in normal and tumor colon tissues are not well defined. Here we evaluated the impact of the colonic fatty acid milieu on formation of prostaglandins and other eicosanoids. Distal tumors in rats were chemically induced to model inflammatory colonic carcinogenesis. After 21 weeks of feeding with either a fish oil diet containing an eicosapentaenoic acid:ω-6 fatty acid ratio of 0.4 or a Western fat diet, the relationships between colon fatty acids and prostaglandin E2 (PGE2) concentrations were evaluated. PGE2 is a key pro-inflammatory mediator in the colon tightly linked with the initiation and progression of colon cancer. The fish oil versus the Western fat diet resulted in reduced total fatty acid concentrations in serum but not in colon. In the colon, the effects of the fish oil on fatty acids differed in normal and tumor tissue. There were distinct lipodomic patterns consistent with a lipogenic phenotype in tumors. In tumor tissue, the eicosapentaenoic acid:arachidonic acid ratio, cyclooxygenase-2 expression and the mole percent of saturated fatty acids were significant predictors of inter-animal variability in colon PGE2 after accounting for diet. In normal tissues from either control rats or carcinogen-treated rats, only diet was a significant predictor of colon PGE2. These results show that the fatty acid milieu can modulate the efficacy of dietary fish oils for colon cancer prevention, and this could extend to other preventive agents that function by reducing inflammatory stress.

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Section: Resultsmentioning

confidence: 99%

“…PC 40:4), as shown in Table 4. More detailed lipodomic data is available in the accompanying Data in Brief article [28]. …”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…All variables were log transformed before analysis. Full fatty acid profiles are shown in the accompanying Data in Brief article [28]. …”

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 3 more Smart Citations

Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: modulation by the lipogenic phenotype of colon tumors

Djurić

Aslam

Simon

et al. 2017

The Journal of Nutritional Biochemistry

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Carcinogenesis: Failure of resolution of inflammation?

Fishbein

Hammock

Serhan

et al. 2021

Pharmacology & Therapeutics

113

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Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a key characteristic of carcinogens. However, the failure of resolution of inflammation in cancer is only recently being understood. Products of arachidonic acid and related fatty acid metabolism called eicosanoids, including prostaglandins, leukotrienes, lipoxins, and epoxyeicosanoids, critically regulate inflammation, as well as its resolution. The resolution of inflammation is now appreciated to be an active biochemical process regulated by endogenous specialized pro-resolving lipid autacoid mediators which combat infections and stimulate tissue repair/regeneration. Environmental and chemical human carcinogens, including aflatoxins, asbestos, nitrosamines, alcohol, and tobacco, induce tumor-promoting inflammation and can disrupt the resolution of inflammation contributing to a devastating global cancer burden. While mechanisms of carcinogenesis have focused on genotoxic activity to induce mutations, nongenotoxic mechanisms such as inflammation and oxidative stress promote genotoxicity, proliferation, and mutations. Moreover, carcinogens initiate oxidative stress to synergize with inflammation and DNA damage to fuel a vicious feedback loop of cell death, tissue damage, and carcinogenesis. In contrast, stimulation of resolution of inflammation may prevent carcinogenesis by clearance of cellular debris via macrophage phagocytosis and inhibition of an eicosanoid/cytokine storm of pro-inflammatory mediators. Controlling the host inflammatory response and its resolution in carcinogen-induced cancers will be critical to reducing carcinogen-induced morbidity and mortality. Here we review the recent evidence that stimulation of resolution of inflammation, including pro-resolution lipid mediators and soluble epoxide hydrolase inhibitors, may be a new chemopreventive approach to prevent carcinogen-induced cancer that should be evaluated in humans.

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Fatty acid and lipidomic data in normal and tumor colon tissues of rats fed diets with and without fish oil

Cited by 2 publications

References 3 publications

Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: modulation by the lipogenic phenotype of colon tumors

Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: modulation by the lipogenic phenotype of colon tumors

Carcinogenesis: Failure of resolution of inflammation?

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