Fatty acid alteration in liver, brain, muscle, and oocyte of zebrafish (Danio rerio) exposed to silver nanoparticles and mitigating influence of quercetin-supplemented diet

Seyedi, Javad; Tayemeh, Mohammad Behzadi; Esmaeilbeigi, Milad; Joo, Hamid Salari; Langeroudi, Elnaz Keshtkar; Banan, Ashkan; Johari, Seyed Ali; Jami, Mohammad Javad

doi:10.1016/j.envres.2020.110611

Cited by 22 publications

(10 citation statements)

References 39 publications

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“…In this study, clinical biochemical analysis of body fluids was carried out for detecting the toxic impacts of these nanoparticles on liver function (21) . In this experimental study, it was found that AgNPs negatively affected the enzymatic parameters of liver function, which was consistent with previous studies (22)(23)(24) . Where disturbances in the levels of biochemical parameters in the serum indicate the unhealthy and pathological state of the liver.…”

Section: Discussionsupporting

confidence: 93%

Toxicity of AgNPs upon Liver Function and Positive Role of Tinospora Cordifolia: In Vivo

Ramadhan¹,

Ghareeb²

2021

PJMHS

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This experiment was premeditated to probe the toxic impact of Silver Nanoparticles (AgNPs) upon liver function parameters in male rats, as well as to demonstrate the protective effect of Tinospora cordifolia (T.C) against liver function disorders caused by AgNPs. Twenty-four rats were classified into four packs, six ones for every pack. Rats were included by control animals without treatment, while the AgNPs group included rats treated with 50μl/kg / day AgNPs. In the AgNPs + T.C group, rats were co-administered of AgNPs at a dose of 50μl/kg with T.C at a dose of 400 mg/kg. Whereas, animals of the T.C pack were treated with 400 mg/kg of T.C. The duration of the experiment was 28 days. After blood samples were taken at the conclusion of the experiment. The levels of biochemical parameters (liver enzymes) such as alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were evaluated to detect liver function abnormalities. Thwe Pw A t e dewoe t ste user e dnoAiwoe se dsnd disnte dnirease in the activity of serum liver enzymes in comparison to the control group (p < 0.05).While T. cordifolia co-treatment significantly reduced the levels of activities of those enzymes. Therefore, it can be considered that T. cordifolia effectively contributes to the protection against liver dysfunction caused by AgNPs in rats. Keywords : Silver Nanoparticles, liver dysfunction, biochemical parameters.

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Section: Discussionsupporting

confidence: 93%

Toxicity of AgNPs upon Liver Function and Positive Role of Tinospora Cordifolia: In Vivo

Ramadhan¹,

Ghareeb²

2021

PJMHS

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“…Notably, brain tissue is highly susceptible to oxidative stress. 8 As shown in Figure 2F, the MDA content in the liver was noticeably increased after AgNS exposure, while it was markedly reduced after AgNF exposure and was nearly unchanged after AgNW exposure. Figure 2G shows that the MDA content in the liver still increased upon exposure to AgNSs but decreased in the AgNW-and AgNF-exposed groups.…”

Section: Effects Of Nanosilver Exposure On the Enzyme Activity Of Var...mentioning

confidence: 75%

“…Given that lipids are closely associated with basic cellular functions and intracellular signal transduction, especially for phospholipids, which play a vital role in organisms as cell membrane components, these lipid variations can be used to reflect the initial toxic effects induced by contaminant exposure. 8,28 Additionally, several MS images of representative lipids in the liver are shown in Figure 6, indicating that LPI(18:0) was obviously increased (Figure 6A), while PS(36:1), PE(40:5), and PI(38:5) were significantly decreased in the AgNSexposed group (Figure 6B−D). The normalized signal intensities of these lipids are represented with box plots in Figure 6E−H.…”

Section: Environmentalmentioning

confidence: 98%

“…As previously reported, lipids play a crucial role in several biological processes in zebrafish, such as cell signaling and energy storage and supply, which has attracted extensive attention due to the close correlation between lipid metabolism and toxic effects. 8,56 Lipids are closely associated with oxidative stress and peroxidation, which can contribute to poisoning behaviors and even death. 57 Thus, we speculate that lipid homeostasis in nanosilver-exposed adult zebrafish can be markedly perturbed in a morphology-dependent manner.…”

Section: Effects Of Nanosilver Exposure On the Enzyme Activity Of Var...mentioning

confidence: 99%

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Mass Spectrometry Imaging Reveals the Morphology-Dependent Toxicological Effects of Nanosilvers on Multiple Organs of Adult Zebrafish (Danio rerio)

Xie,

Li,

Chen

et al. 2024

Environ. Sci. Technol.

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Nanosilvers with multifarious morphologies have been extensively used in many fields, but their morphology-dependent toxicity toward nontarget aquatic organisms remains largely unclear. Herein, we used matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to investigate the toxicological effects of silver nanomaterials with various morphologies on spatially resolved lipid profiles within multiple organs in adult zebrafish, especially for the gill, liver, and intestine. Integrated with histopathology, enzyme activity, accumulated Ag contents and amounts, as well as MSI results, we found that nanosilvers exhibit morphology-dependent nanotoxicity by disrupting lipid levels and producing oxidative stress. Silver nanospheres (AgNSs) had the highest toxicity toward adult zebrafish, whereas silver nanoflakes (AgNFs) exhibited greater toxicity than silver nanowires (AgNWs). Levels of differential phospholipids, such as PC, PE, PI, and PS, were associated with nanosilver morphology. Notably, we found that AgNSs induced greater toxicity in multiple organs, such as the brain, gill, and liver, while AgNWs and AgNFs caused greater toxicity in the intestine than AgNSs. Lipid functional disturbance and oxidative stress further caused inflammation and membrane damage after exposure to nanosilvers, especially with respect to sphere morphology. Taken together, these findings will contribute to clarifying the toxicological effects and mechanisms of different morphologies of nanosilvers in adult zebrafish.

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“…Secondly, ovaries are lipid‐rich organs compared to the testes, and metals bond to various metals, which are major factors catalyzing lipid peroxidation in biological systems (Schaich 1992; Valko et al 2005). Because of this, ovaries can have a higher bioaccumulation of metals (e.g., Mediterranean mussel: Richir and Gobert 2014) and related alterations as compared to the testes (Seyedi et al 2021). Furthermore, metals can act as endocrine disruptors of vitellogenesis in bivalves, mainly Cd (e.g., softshell clam Mya arenaria : Gauthier‐Clerc et al 2002; truncate donax: Kheroufi et al 2021), which can delay gametogenesis in females.…”

Section: Discussionmentioning

confidence: 99%

Histopathological alterations in the gonads of wild white clams Dosinia ponderosa inhabiting a former copper mine locality in the Gulf of California

Eraso‐Ordoñez,

Yee‐Duarte,

Roldán‐Wong

et al. 2023

J Aqua Anim Hlth

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Objective Prolonged exposure to heavy metals, such as Pb, Hg, or Cu, has multiple adverse effects on marine organisms at the cellular, physiological, and population levels. Bivalves' histopathology provides a sensitive biomarker of pollutant‐induced stress and environmental health. Gonad tissue deterioration is of particular concern, as it affects the reproductive success of a species. This study aimed to examine the histopathological alterations caused by metal exposure in the gonad of the white clam Dosinia ponderosa. Methods Organisms were sampled from three locations in the Gulf of California: Santa Rosalia (SR), a former Cu mining town; San Lucas beach (SL), a nearby site influenced by pollution; and Escondida beach (EB), which served as a control site. Histological and histochemical stains were used, and the prevalence and intensity level of each alteration were calculated. Result The prevalence of alterations was higher in the ovaries of SR clams (92% compared to 60% in SL clams and 32.7% in EB clams), during spawning (91.4% compared to 20% in SL clams and 4.7% in EB clams), and in winter (93.5% compared to 30% in SL clams and 17.4% in EB clams). Conclusion These findings suggest a significant deterioration in the gonads of white clams from SR, probably linked to the chronic exposure to high concentrations of Cu and possibly other heavy metals; hence, the reproductive health of the clams is likely compromised.

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Fatty acid alteration in liver, brain, muscle, and oocyte of zebrafish (Danio rerio) exposed to silver nanoparticles and mitigating influence of quercetin-supplemented diet

Cited by 22 publications

References 39 publications

Toxicity of AgNPs upon Liver Function and Positive Role of Tinospora Cordifolia: In Vivo

Toxicity of AgNPs upon Liver Function and Positive Role of Tinospora Cordifolia: In Vivo

Mass Spectrometry Imaging Reveals the Morphology-Dependent Toxicological Effects of Nanosilvers on Multiple Organs of Adult Zebrafish (Danio rerio)

Histopathological alterations in the gonads of wild white clams Dosinia ponderosa inhabiting a former copper mine locality in the Gulf of California

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