Fatores genéticos e ambientais envolvidos na degeneração do disco intervertebral

Nunes, Francine Teresa Brioni; Conforti-Froes, Nívea; Negrelli, Wilson Fábio; Souza, Dorotéia Rossi Silva

doi:10.1590/s1413-78522007000100002

Cited by 20 publications

(10 citation statements)

References 16 publications

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“…Women have the mission of reconciling domestic tasks and professional activities, increasing biomechanical requirements, which makes them more susceptible to ergonomic aggressions, especially repetitiveness, vicious positions and prolonged work 2,9 , probably contributing to a higher female prevalence among patients with low back pain in our study. Several studies report age as risk factor for low back pain 2,5 . With aging, the intervertebral disk looses its hygroscopic feature, suffering progressive dehydration and consequent degeneration, and the spine starts to present progressive instability and pain in the affected region.…”

Section: Discussionmentioning

confidence: 99%

“…With aging, the intervertebral disk looses its hygroscopic feature, suffering progressive dehydration and consequent degeneration, and the spine starts to present progressive instability and pain in the affected region. These problems occur in any spinal region, however they are more common between the fourth and fifth lumbar vertebrae and between the fifth lumbar and first sacral vertebrae 5,10 . The relation between years working in the same sector and the prevalence of low back pain is justified as a function of daily body requirements to perform professional activities.…”

Section: Discussionmentioning

confidence: 99%

“…The ability to perform both functions is provided by mechanisms which ensure the maintenance of vertebral alignment 3 . Studies have shown that low back pain etiology is multifactorial, with biomechanical causes, individual characteristics and occupational factors, since the musculoskeletal system is subject to unbalance when submitted to inadequate conditions which directly affect body posture, such as after long periods in antiergonomic sitting position 4,5 . In this position, body weight support rests on ischial tuberosities and adjacent soft tissues and the trunk is maintained straight by the constant activity of abdominal and dorsal muscles.…”

Section: Introductionmentioning

confidence: 99%

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Lombalgia ocupacional e a postura sentada: efeitos da cinesioterapia laboral

Freitas¹,

Barros²,

Angelo³

et al. 2011

Rev. dor

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lombalgia ocupacional e a postura sentada: efeitos da cinesioterapia laboral

Freitas¹,

Barros²,

Angelo³

et al. 2011

Rev. dor

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“…Os genes do receptor da vitamina D e da glutatião transferases M1 e T1, bem como o hábito de fumar, são fatores genéticos e ambientais envolvidos na degeneração do disco intervertebral (40) . Oliveira et al concluíram que as fibras nervosas do tipo III são mais frequentes na região anterior; as fibras dos tipos II e IV são mais frequentes na região posterior; e as fibras do tipo I não apresentaram diferenças entre a região anterior e a posterior; além disso, o disco degenerado tem mais fibras nervosas que o disco normal (41) . Demange et al estudaram o ligamento da cabeça do fêmur e concluíram que o mesmo influi limitando a adução do quadril (42) .…”

Section: Ortopediaunclassified

Artigos publicados em periódicos brasileiros de interesse para a medicina do exercício e do esporte: uma revisão

Hernandez¹

2009

Rev Bras Med Esporte

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RESUMoEsta nova série de artigos tem por objetivo levar aos leitores nacionais e internacionais algumas das mais importantes contribuições provenientes da literatura médica brasileira recente. Embora possa parecer que não tenham relação direta com a Medicina do Exercício e do Esporte, são trabalhos que podem oferecer suporte a muitas linhas de pesquisa nessa área. Os artigos originais mais relevantes são selecionados por experientes editores, a quem solicitamos que escolham palavras-chave para que sejam destacadas para chamar a atenção do leitor. Para facilitar a leitura, os artigos são organizados por área de interesse. Para aproveitar ao máximo o limitado espaço editorial, não são incluídos os nomes dos autores dos artigos. Entretanto, a referência completa é oferecida ao final do artigo. O resultado final traz o que há de melhor do artigo, seguido de uma sintética interpretação pessoal. Endereçado ao médico ocupado, esperamos que esta inciativa possa contribuir para o sucesso da translação do conhecimento da evidência científica para a prática clínica. Palavras-chave: medicina esportiva, cardiologia, ortopedia, nutrição. aBStRaCtThis brand-new series of articles aims at delivering to national and international readers some of the cutting-edge contributions from the Brazilian medical literature. Some of them may not be directly related to the area, but they can be the grounding for scientific research in the field of Sports and Exercise Medicine. Recently, papers published in the main Brazilian medical journals are carefully selected and analyzed by skilled medical editors. In addition, we asked editors to choose keywords to be highlighted in order to call the reader' s attention. Articles are organized by area of interest to facilitate reading. To get the most of the limited available editorial space we did not include the names of the authors of the related articles in the text itself, but a complete reference guide is provided at the end of the article. The result carries the best from the original paper accompanied by a personal interpretation. Directed to the busy medical doctor, we hope that this initiative may contribute to the successful translation of knowledge from scientific evidence to clinical practice.

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“…However, the etiology of degenerative disc disease (DDD) is complex. Although environmental, ergonomic, and anthropometric factors have traditionally been determined as causes, several studies have suggested that genetic factors or familial predisposition contribute to the degeneration and consequent herniation of intervertebral discs (Battié et al, 2004;Brioni Nunes et al, 2007;Zhang et al, 2008;Eser et al, 2010;Paz Aparicio et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

CASE-REPORT Association between an ACAN gene variable number tandem repeat polymorphism and lumbar disc herniation: a case control study

et al. 2016

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ABSTRACT. We investigated the association between an aggrecan gene (ACAN) polymorphism and lumbar disc herniation (LDH). This was a case-control study with quinquennial age and gender groups. The study comprised 119 men and women aged between 20 and 60 from Goiânia (Brazil). Of these, 39 were allocated to the case group (Ca) and 80 to the control group (Ct). We gathered sociodemographic and clinical data, and peripheral blood samples. DNA was isolated for genotyping the ACAN variable number tandem repeat (VNTR) via conventional polymerase chain reaction (PCR). Data were statistically analyzed using the chi-square test, multiple comparison analysis, the Student t-test, and odds ratios, with a level of significance set at 5% (P ≤ 0.05). The groups were homogenous in terms of sociodemographic, anthropometric, and life style variables. The allele score for the ACAN VNTR was significantly lower in volunteers with LDH; the A22 allele was significantly more prevalent in this same group; the Ca group presented greater frequency of short alleles A13-A25, whereas the Ct group presented a higher frequency of long alleles. However, this difference was not statistically significant. In both groups, the most common alleles were A28, A27, and A29, and the A26/A26 genotype was significantly more common in the Ca group. The results showed an association between short alleles and LDH among the investigated adults (Ca), corroborating the hypothesis that aggrecan with shorter repeat lengths can lead to a reduction in the physiological proteoglycan function of intervertebral disc hydration and, consequently, increased individual susceptibility to LDH.

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Fatores genéticos e ambientais envolvidos na degeneração do disco intervertebral

Cited by 20 publications

References 16 publications

Lombalgia ocupacional e a postura sentada: efeitos da cinesioterapia laboral

Lombalgia ocupacional e a postura sentada: efeitos da cinesioterapia laboral

Artigos publicados em periódicos brasileiros de interesse para a medicina do exercício e do esporte: uma revisão

CASE-REPORT Association between an ACAN gene variable number tandem repeat polymorphism and lumbar disc herniation: a case control study

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