Fatores de risco para o câncer de esôfago: estudo caso-controle em área metropolitana da região Sudeste do Brasil

Gimeno, Suely Godoy Agostinho; Souza, José María Pacheco de; Mirra, Antônio Pedro; Correa, Pelayo; Haenszel, William

doi:10.1590/s0034-89101995000300002

Cited by 12 publications

(10 citation statements)

References 21 publications

(20 reference statements)

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“…Although many authors have described a higher risk of esophageal neoplasia among smokers of 20 or more cigarettes per day, 7,26,37 we have not observed a statistically significant difference ( P > 0.05) in our study involving a considerable number of patients who had begun to smoke before 15 years of age, with a consumption of more than 11 cigarettes per day, and total lifetime tobacco intake (Brinkman’s index) higher than 600.…”

Section: Discussioncontrasting

confidence: 80%

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Dietary habits, ethanol and tobacco consumption as predictive factors in the development of esophageal carcinoma in patients with head and neck neoplasms

et al. 2008

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Patients with primary head and neck cancers have a higher risk of developing esophageal cancer. The aim of this study was to investigate esophageal cancer prevalence, its risk factors (ethanol and tobacco consumption) and dietary habits in patients with head and neck cancer. Three hundred and twenty-six adults with primary head and neck cancer were followed by a retrospective observational study in a general university hospital in Sao Paulo, Brazil. Flexible videoendoscopy with lugol chromoscopy was the method used to investigate esophageal cancer prevalence. All subjects were interviewed face-to-face, revealing detailed information about their tobacco and alcohol use, as well as their dietary habits. Thirty-six patients with esophageal cancer were diagnosed and the overall prevalence rate was 11.04%. Patients who developed second esophageal tumors had the following characteristics: earlier age of initial ethanol consumption (P < 0.05), longer duration period of ethanol consumption (P < 0.05) and higher weekly consumption rate (P < 0.05). There was an increased risk of esophageal carcinoma in those patients who both smoked and drank (P < 0.05). There was no association between carcinoma of the esophagus and dietary habits in patients who developed esophageal neoplasms, compared with those who did not. Prevalence rate of esophageal neoplasms was 11.04% in patients with head and neck carcinoma, whose ethanol consumption was associated with esophageal cancer. There was an increased risk between ethanol and tobacco consumption and esophageal carcinoma development. On the other hand, there was no association regarding dietary habits between patients who developed esophageal cancer and those who did not.

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Section: Discussioncontrasting

confidence: 80%

“…Alcohol and tobacco are two well known major risk factors for cancer of the esophagus 4,5,7,16,21–23,25–36 …”

Section: Discussionmentioning

confidence: 99%

Dietary habits, ethanol and tobacco consumption as predictive factors in the development of esophageal carcinoma in patients with head and neck neoplasms

et al. 2008

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“…Esophageal cancer is more frequent in older male individuals 5,6 , generally being associated with ethylism and tabagism 7 , intake of hot drinks and foods 8 , vitamin deficiencies 7 , ingestion of caustic substances 9 , Barrett Esophagus (BE) 10 , megaesophagus 11 and human papiloma virus infection 12 .…”

Section: Introductionmentioning

confidence: 99%

Epidemiological features of esophageal cancer. Squamous cell carcinoma versus adenocarcinoma

et al. 2014

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PURPOSE:To analyze the epidemiological features of patients with esophageal cancer according to the histopathological types: squamous cell carcinoma or adenocarcinoma. METHODS:A total of 100 patients with esophageal cancer, being 50 squamous cell carcinomas and 50 adenocarcinomas were analyzed for demographics, nutritional factors, lifestyle habits, benign pathological conditions associated, like Barrett's esophagus and megaesophagus, tumor stage and survival rates. The nutritional factors evaluated included body mass index, percent weight loss, hemoglobin and albumin serum levels. RESULTS:Esophageal cancer occurred more often in men over 50 years-old in both histological groups. No significant differences on age and gender were found between the histological groups. Squamous cell carcinoma was significantly more frequent in blacks than adenocarcinoma. Alcohol consumption and smoking were significantly associated with squamous cell carcinoma. Higher values of body mass index were seen in patients with adenocarcinoma. Barrett's esophagus was found in nine patients (18%) with adenocarcinoma, and megaesophagus in two patients (4%) with squamous cell carcinoma. The majority of patients were on stages III and IV in both histological groups. The mean survival rates were 7.7 ± 9.5 months for patients with squamous cell carcinoma and 8.0 ± 10.9 months for patients with adenocarcinoma. No significant differences on tumor stage and survival rates were detected between the histological groups.CONCLUSION: Epidemiological features are distinct for the histopathological types of esophageal cancer. Squamous cell carcinoma is associated with black race, alcohol and smoking, while adenocarcinoma is related to higher body mass index, white race and Barrett's esophagus.

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“…Foram utilizados dados de um estudo caso-controle sobre câncer de esófago 6 . Oitenta e cinco casos de câncer de esôfago foram comparados com 292 controles hospitalares, classificados segundo segundo sexo, idade e os hábitos de beber e de fumar.…”

Section: Materials E Métodounclassified

Utilização de estratificação e modelo de regressão logística na análise de dados de estudos caso-controle

Gimeno

Souza

1995

Rev. Saúde Pública

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Exemplifica-se a aplicação de análise multivariada, por estratificação e com regressão logística, utilizando dados de um estudo caso-controle sobre câncer de esôfago. Oitenta e cinco casos e 292 controles foram classificados segundo sexo, idade e os hábitos de beber e de fumar. As estimativas por ponto dos odds ratios foram semelhantes, sendo as duas técnicas consideradas complementares. Análise multivariada. Regressão logística. Estudos de casos e controles.Em Epidemiologia, a regressão logística tem como objetivo descrever a relação entre um resultado (variável dependente ou resposta) e um conjunto simultâneo de variáveis explicativas (preditoras ou independentes), mediante um modelo que tenha bom ajuste, que seja biologicamente plausível e obedeça ao princípio da parcimônia 5 . Na análise estratificada tem-se o mesmo propósito, mas as relações são efetuadas uma a uma, isto é, somente é possível obter a estimativa do risco para um único fator de cada vez, controlando-se o conjunto das demais variáveis.Podem ser citadas como vantagens da análise estratificada sua relativa simplicidade de execução, a facilidade de entendimento e maior proximidade que propicia entre o pesquisador e os dados. Entretanto, ao se aplicar essa técnica, o grau de dificuldade aumenta na medida em que aumenta o número de variáveis que tiverem que ser consideradas como controle; os testes de homogeneidade entre os estratos, para se verificar a existência de interação entre as variáveis, são feitos em etapa à parte; variáveis quantitativas não podem ser usadas em sua escala original; o nível global de significância é difícil de ser controlado 3,7 .A análise logística controla grande número de variáveis simultaneamente, permitindo que os dados sejam utilizados mais eficientemente; o teste de homogeneidade pode ser feito em conjunto, bastando introduzir no modelo o termo produto entre os fatores. Uma possível desvantagem é a eventual barreira que introduz entre o pesquisador e os dados; é praticamente obrigatório o uso de pacotes estatísticos e microcomputador 4,5 .O presente trababalho exemplifica a utilização das análises estratificada e logística na análise de dados de estudos tipo caso-controle. Material e MétodoForam utilizados dados de um estudo caso-controle sobre câncer de esófago 6 . Oitenta e cinco casos de câncer de esôfago foram comparados com 292 controles hospitalares, classificados segundo segundo sexo, idade e os hábitos de beber e de fumar. O hábito de beber foi considerado fator de risco de principal interesse.Foi verificada a existência de associação entre o câncer de esôfago e cada uma das variáveis, em uma primeira etapa (análise bruta), mediante a obtenção das estimativas dos odds ratios (OR), por ponto e por intervalo, além do valor da estatística quiquadrado de Mantel-Haenszel (c 2 MH ) 1,2,9,10 . Nas etapas seguintes foram selecionadas as variáveis cujo Separatas/Reprints: José Maria Pacheco de Souza -Av. Dr. Arnaldo, 715 -01246-904 -São Paulo, SP -Brasil -Fax: (011) 282. 2920 Edição subvencionada pela FAPESP. Pro...

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Fatores de risco para o câncer de esôfago: estudo caso-controle em área metropolitana da região Sudeste do Brasil

Cited by 12 publications

References 21 publications

Dietary habits, ethanol and tobacco consumption as predictive factors in the development of esophageal carcinoma in patients with head and neck neoplasms

Dietary habits, ethanol and tobacco consumption as predictive factors in the development of esophageal carcinoma in patients with head and neck neoplasms

Epidemiological features of esophageal cancer. Squamous cell carcinoma versus adenocarcinoma

Utilização de estratificação e modelo de regressão logística na análise de dados de estudos caso-controle

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