Fatigue, Weight Gain, and Altered Sexuality in Patients With Breast Cancer: Exploration of a Symptom Cluster

Wilmoth, Margaret C.; Coleman, Elizabeth Ann; Smith, Steven C.; Davis, Carla

doi:10.1188/04.onf.1069-1075

Cited by 73 publications

(54 citation statements)

References 59 publications

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“…3,4 Despite an awareness that toxicities rarely occur independent of each other, the majority of research in supportive cancer care has focused only on individual symptoms, such as fatigue, 5 mucositis, 6 anxiety or alopecia, 7 nausea/vomiting, hematologic toxicity, 9 or pain. 10 This paradigm is currently shifting to the study of symptom clusters, [11][12][13] most of which have been defined using conventional hierarchical analysis.…”

mentioning

confidence: 99%

Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy

Aprile

Ramoni

Keefe

et al. 2007

Cancer

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mentioning

confidence: 99%

Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy

Aprile

Ramoni

Keefe

et al. 2007

Cancer

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“…Entre los factores etiológicos pueden nombrarse la fatiga experimentada, la menopausia temprana, la sensación de sofoco, el dolor en la relación sexual (dispareunia), cambios en el estado de ánimo, así como la resequedad vaginal que pueden disminuir las respuestas sexuales consideradas normales y alterar la percepción de intimidad en la mujer (17,18) . En un estudio de Schag et al (1993), donde se evaluaron las características de mujeres en riesgo de sufrir de malestar psicológico un año después del diagnóstico de cáncer de mama, se encontró que más de un tercio de estas mujeres se quejan de alteraciones en su vida sexual (19) .…”

Section: Evidencia Que Sugiere Dificultades En La Sexualidadunclassified

“…Por último pero no menos importante está el tratamiento de radioterapia, responsable por cambios en la piel provocados por la radiación (e.g., eritemas y quemaduras). Estos efectos no suelen ser prolongados en el tiempo, y generalmente han desaparecido algunos meses después del procedimiento por lo que la mujer no experimenta un impacto sustancial en su calidad de vida (18,49) . Desafortunadamente, en los casos más graves existe la posibilidad de que se registren manifestaciones cróni-cas derivadas de la radiación en el seno, que incluyen la pigmentación de la piel, retracción, eritema, fibrosis y que resulta en una reducción de la estética del seno y de la movilidad del brazo (42,52,53) .…”

Section: Evidencia Que Sugiere Dificultades En La Sexualidadunclassified

Cuando el cáncer de seno no significa insatisfacción sexual. Un estudio comparativo

Finck¹,

Barradas²,

Agudelo³

et al. 2012

Psicooncología

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ResumenEl cáncer de seno es considerado un problema de salud pública, en la medida en que actualmente se presenta como uno de los factores más comunes de morbimortalidad en mujeres de países de todo el mundo, y de Colombia. Aunque se haya verificado un aumento importante en el número de sobrevivientes de cáncer de seno, la vivencia de esta enfermedad puede comprometer aspectos relacionados con la sexualidad, lo que implica atribuir mayor relevancia a los procesos de adaptación psicosocial, y a su impacto en la calidad de vida de estas mujeres. Este estudio busca evaluar los niveles de satisfacción sexual de pacientes con cáncer de seno. Para esto, se recolectaron datos de 100 mujeres sanas y de 84 pacientes con diagnóstico de cáncer de seno, en un hospital universitario en la ciudad de Bogotá. AbstractBreast cancer is currently considered a public health problem, since it is one of the most common factors of morbidity and mortality in women in countries around the world, and also in Colombia. Although there has been an increase in the number of breast cancer survivors, the experience of the disease may compromise sexuality aspects, which highlights the importance of the process of psychological adaptation, and its impact on the quality of life of these women. This study aims to assess the levels of sexual dissatisfaction in patients with breast cancer. For this purpose, 100 healthy women were interviewed and their answers were compared to those of 84 patients diagnosed with breast cancer, contacted through a university hospital in Bogotá. The Index of Sexual Satisfaction (ISS) and the Supplementary Questionnaire Breast Cancer Module (EORTC QLQ BR-23) were applied. The results showed significant differences in the level of sexual dissatisfaction in both groups (t (156) = 9.33, p<0.001), where the group of patients was less dissatisfied with their sexuality (M=24.6, SD=17.5), compared with the group of healthy women (M=46.9, SD=12.4). The treatments that are mostly CUANDO EL CÁNCER DE SENO NO SIGNIFICA INSATISFACCIÓN SEXUAL. UN ESTUDIO COMPARATIVO ENTRE PACIENTES Y UN GRUPO DE MUJERES SANAS EN COLOMBIA WHEN BREAST CANCER DOES NOT MEAN SEXUAL DISSATISFACTION.

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“…Furthermore, if these symptom clusters arise from a common mechanism and are amenable to a common intervention, clinicians can then manage and treat multiple symptoms within the same cluster, which may lead to improvements in quality of life, adherence to treatment, and therapeutic benefit. [9][10][11] In recent years, symptom clusters have been evaluated across a variety of cancers, [12][13][14] with several studies in breast cancer, [15][16][17] lung cancer, [18][19][20] and non-Hodgkin lymphoma 21 and across multiple cancer sites. [22][23][24][25][26][27][28][29][30][31][32] Each of these studies prospectively collected patient-reported symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies used the MD Anderson symptom inventory, 11,29 whereas others used self-developed symptom checklists. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]28 The level of detail with which symptoms are collected and the symptoms that are included vary across these instruments. The lack of uniformity regarding selected symptoms scales and instruments likely contributed to the lack of consistency of the symptom clusters identified.…”

Section: Introductionmentioning

confidence: 99%

ReCAP: Identifying Severe Adverse Event Clusters Using the National Cancer Institute’s Common Terminology Criteria for Adverse Events

Zhong

Lim

Hershman

et al. 2016

JOP

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CONTEXT & QUESTION ASKED: Exploring the relationship among adverse events is important because those that arise from a common mechanism are amenable to a common intervention, which can improve symptom management, quality of life, and treatment adherence. To date, symptom cluster studies have used patient-reported data, which are not always available in clinical trials. In this study, we proposed using the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) to identify adverse event clusters because the CTCAE are collected as standard practice and can therefore be used when patient-reported outcomes are unavailable. Hence, is it feasible to identify severe adverse events clusters from data captured using the CTCAE in clinical trials? SUMMARY ANSWER: Six severe adverse events clusters were identified in patients with advanced prostate cancer. Identifying adverse events clusters using CTCAE data from clinical trials is feasible. METHODS: A variable-based hierarchical cluster analysis was conducted using the CTCAE data captured from 323 patients who experienced at least one grade 3 or higher adverse event in an advanced prostate cancer randomized clinical trial conducted by SWOG (S9916). BIAS, CONFOUNDING FACTOR(S), DRAWBACKS: The difficulty of using adverse event data from clinical trials is that often not all adverse events are recorded. In our study, only the highest severity grade for each adverse event type was recorded, and only grade 3 or higher adverse events were captured reliably. Moreover, in contrast to previous publications on symptom cluster that used patient-reported outcomes, the CTCAE is clinician reported and may not accurately reflect the presence of patient symptoms and the severity of these symptoms. REAL-LIFE IMPLICATIONS: Capturing adverse events using the CTCAE, which is standard practice in all clinical trials, can be used to understand the relationships among adverse events and to identify adverse events clusters when patient-reported outcomes are unavailable. [Figure: see text]

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Fatigue, Weight Gain, and Altered Sexuality in Patients With Breast Cancer: Exploration of a Symptom Cluster

Abstract: Nurses should view symptoms caused by breast cancer treatment holistically, keeping in mind that a reciprocal relationship often exists among symptoms. Identification of symptom clusters with empirically derived interventions may enhance quality of care and quality of life for patients.

Cited by 73 publications

References 59 publications

Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy

Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy

Cuando el cáncer de seno no significa insatisfacción sexual. Un estudio comparativo

ReCAP: Identifying Severe Adverse Event Clusters Using the National Cancer Institute’s Common Terminology Criteria for Adverse Events

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