Fatigue Syndromes and the Aetiology of Autoimmune Disease

Poteliakhoff, Alex

doi:10.1300/j092v04n04_04

Journal of Chronic Fatigue Syndrome

1998

DOI: 10.1300/j092v04n04_04

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Fatigue Syndromes and the Aetiology of Autoimmune Disease

Alex Poteliakhoff

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Cited by 6 publications

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“…Changes in the responsiveness of the HPA axis, a major arm of the stress response, could imply a heightened or decreased stress response. This is comparable with literature characterizing CFS as a stress‐related disorder in that many individuals with CFS reported increased symptomatology and/or illness flare‐ups or relapses after periods of severe stress (Lutgendorf et al., 1995), and stress has been proposed by some researchers to cause dysfunction in both the endocrine and immune systems in CFS (Poteliakhoff, 1998). Hypocortisolism has been found to occur in several physiological and psychological disorders, including CFS, FM, chronic pelvic pain, irritable bowel syndrome, and PTSD (Fries et al., 2005).…”

supporting

confidence: 84%

The Associations Between Basal Salivary Cortisol and Illness Symptomatology in Chronic Fatigue Syndrome

Torres-Harding

Sorenson

Jason

et al. 2008

J Appl Biobehavioral Res

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Hypocortisolism has been reported in chronic fatigue syndrome (CFS), with the significance of this finding to disease etiology unclear. This study examined cortisol levels and their relationships with symptoms in a group of 108 individuals with CFS. CFS symptoms examined included fatigue, pain, sleep difficulties, neurocognitive functioning, and psychiatric status. Alterations in cortisol levels were examined by calculation of mean daily cortisol, while temporal variation in cortisol function was examined by means of a regression slope. Additionally, deviation from expected cortisol diurnal pattern was determined via clinical judgment. Results indicated that fatigue and pain were associated with salivary cortisol levels. In particular, variance from the expected pattern of cortisol was associated with increased levels of fatigue. The implications of these findings are discussed.Keywords salivary cortisol; chronic fatigue syndrome; cognitive functioning; pain; fatigue Chronic fatigue syndrome (CFS) is an illness characterized by severe, disabling fatigue that is not alleviated with rest, and by flu-type symptoms including sore throats, muscle pain, joint pain, headaches, memory/concentration difficulties, unrefreshing sleep, and postexertional malaise (Fukuda, et al. 1994). The causes of CFS are currently unknown, and, as of yet, no clear diagnostic marker for this illness has emerged. Physiological studies have suggested the presence of dysfunction in the immune, endocrine, and neurological systems, NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript and researchers have found numerous abnormalities in these systems. However, many of these physiological abnormalities have not been replicated across studies, and a confusing picture still exists regarding the pathophysiology of this illness. Most recently, it has been suggested that individuals with CFS constitute a heterogeneous population, and little progress in clearly delineating the physiology of this illness may have resulted because of the presence of distinct subgroups within this larger umbrella diagnosis (Jason, Corradi, Torres-Harding, Taylor, & King, 2005).However, some abnormalities have been more consistently reported in the literature as affecting a subset of individuals with CFS. One finding frequently reported is a dysfunction of the hypothalamic-pituitary-adrenal axis, (HPA) with resulting hypocortisolism (Addington, 2000;Cleare, 2003). Cortisol, a glucocorticoid, is the major end product of the HPA axis and is involved in regulation of several bodily systems. Some researchers have noted that approximately 20-25% of individuals with CFS and related disorders such as fibromyalgia or post-traumatic stress disorder have exhibited hypocortisolism and downregulation of the HPA axis (Fries, Hesse, Hellhammer, & Hellhammer, 2005). Cleare (2003), in a review of the literature examining HPA dysfunction in CFS, found that many, but not all, studies of cortisol in CFS found lower levels of baseline cortisol and changes in sen...

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supporting

confidence: 84%

The Associations Between Basal Salivary Cortisol and Illness Symptomatology in Chronic Fatigue Syndrome

Torres-Harding

Sorenson

Jason

et al. 2008

J Appl Biobehavioral Res

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Etanercept and methotrexate in rheumatoid arthritis

Poteliakhoff¹

2004

The Lancet

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Stress and asthma

Poteliakhoff¹

2000

The Lancet

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Fatigue Syndromes and the Aetiology of Autoimmune Disease

Cited by 6 publications

References 35 publications

The Associations Between Basal Salivary Cortisol and Illness Symptomatology in Chronic Fatigue Syndrome

The Associations Between Basal Salivary Cortisol and Illness Symptomatology in Chronic Fatigue Syndrome

Etanercept and methotrexate in rheumatoid arthritis

Stress and asthma

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