This work focuses on applying a novel and integrated multi-objective optimization approach to enhance the strength of the railway bogie frame system under both static loads and fatigue tests. The finite element modelling is conducted using ANSYS/Workbench software, and the von Mises stress and fatigue safety factor of the bogie frame are computed through conventional simulations for EN 13749 and EN 15663 testing. After employing the uniform design method, the fatigue safety factor is increased from 1.924 to 2.586, resulting in a 34.41% improvement rate for the bogie frame. Additionally, the von Mises stress is reduced from 56.96 MPa to 42.91 MPa, reflecting a 24.66% improvement rate compared to the original design. Following the implementation of the multi-objective optimum design process, the fatigue safety factor further improves from 1.924 to 2.742, resulting in a 42.51% enhancement for the bogie frame. Simultaneously, the von Mises stress decreases from 56.96 MPa to 40.48 MPa, yielding an improvement rate of 28.92%.