Fatigue in systemic lupus erythematosus

Yılmaz-Öner, Sibel; İlhan, Birkan; Can, Meryem; Alıbaz-Öner, Fatma; Polat-Korkmaz, O.; Özen, Gülşen; Mumcu, Gonca; Kremers, Hilal Maradit; Direşkeneli, Haner

doi:10.1007/s00393-016-0185-0

Cited by 28 publications

(10 citation statements)

References 40 publications

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“…A recent study in Turkey showed that disease activity was not related to fatigue. 15 Our study has indicated that fatigue was not associated with disease activity, but it was related to the disease duration. The possible explanation may be that the proportion of SLE patients with damage increased significantly with disease duration, 26 which may affect SLE patients’ fatigue and the quality of life.…”

Section: Discussionmentioning

confidence: 66%

“…Interestingly, logistic regression analysis indicated that depression played an important role in fatigue, which was consistent with previous studies. 15 , 34 The data suggested the need for systemic psychiatric screening and management and the importance of helping SLE patients to develop cognitive, behavioral and emotional strategies, which can relieve fatigue and improve quality of life. 4 , 35 …”

Section: Discussionmentioning

confidence: 99%

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Fatigue of systemic lupus erythematosus in China: contributors and effects on the quality of life

Du¹,

Zhao²,

Zhuang³

et al. 2018

PPA

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ObjectiveFatigue is a very common symptom of systemic lupus erythematosus (SLE), which significantly impairs patients’ quality of life. The purpose of this study is to evaluate contributors of fatigue and effects of fatigue on the quality of life in Chinese SLE patients.MethodsA survey of 119 SLE patients using the Fatigue Severity Scale (FSS) to assess the severity of fatigue was carried out. SLE patients completed the Systemic Lupus Erythematosus Disease Activity Index, the Hospital Anxiety and Depression Scale, the Short Form 36 health survey and the Pittsburgh Sleep Quality Index. Meanwhile, 105 healthy individuals completed FSS, the Hospital Anxiety and Depression Scale and Short Form 36 health survey. We used chi-squared analysis, independent samples t-tests and logistic regression models to analyze data.ResultsOur results found that the FSS score of patients with SLE was higher than that of healthy controls. The disease duration, anxiety, depression, subjective sleep quality and sleep disorders significantly correlated with fatigue in SLE patients. Moreover, logistic regression models showed depression and sleep disorders as predictors of fatigue. In SLE patients, fatigued patients had lower quality of life than those who were non-fatigued.ConclusionThis is the first time to explore contributors of fatigue and the influence of fatigue on SLE patients’ quality of life in China. Our study showed that depression and sleep disorders were predictors of fatigue, and fatigue seriously damaged SLE patients’ quality of life. The results indicate that it is necessary to conduct holistic assessment and effective intervention, such as systemic psychiatric screening, psychological care and practical sleep guidance, to relieve symptoms of fatigue and finally improve their quality of life in SLE patients.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Fatigue of systemic lupus erythematosus in China: contributors and effects on the quality of life

Du¹,

Zhao²,

Zhuang³

et al. 2018

PPA

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“…A high prevalence of fatigue seen in patients with clinically diagnosed depression points toward a relationship between the 2 conditions. Depressed mood has a strong positive association with fatigue in SLE (15,16,19,40,41). Anxiety and depressive symptoms are highly prevalent among patients with SLE and are thought to represent central nervous system involvement, immune dysfunction manifestation, and cognitive processes related to the emotional burden of the disease (39).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Study of Fatigue, Stress, and Depression: Role of Reduction in Stress Toward Improvement in Fatigue

Azizoddin

Jolly

Arora

et al. 2020

Arthritis Care & Research

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Objective Fatigue is common among individuals with systemic lupus erythematosus (SLE), but the causes are not well understood. Our objective was to examine perceived stress and depressive symptoms as predictors of fatigue in SLE. Methods Data from 2 years of the Lupus Outcomes Study (n = 650 patients), obtained through annual structured interviews, were used. Fatigue was measured with the Short Form 36 (SF‐36) vitality scale along with a variety of self‐report measures of disease, depression, and stress. Multivariate linear regression models examined predictors of changes in fatigue. Model 1 tested the association of time 1 (T1) depression with time 2 (T2) fatigue; model 2 added T1 perceived stress to model 1, and final models added T1‐to‐T2 decrease in stress. All analyses controlled for T1 fatigue, age, sex, self‐report of fibromyalgia, pain, and SLE duration, activity, and damage. Results Mean ± SD age was 51 ± 12 years, 92% of participants were women, and 68% were white. The mean ± SD SF‐36 fatigue score was 55 ± 24. T1 depression significantly predicted T2 fatigue. When T1 stress was added, stress (β = 1.7 [95% confidence interval (95% CI) 1.1, 2.2]; P < 0.0001) significantly predicted T2 fatigue, but depression was no longer significant. The addition of T1‐to‐T2 decrease in stress was associated with a clinically meaningful decline in fatigue (β = –11.8 [95% CI –15.6, –8.9]; P < 0.0001). Conclusion While depressive symptoms initially predicted subsequent fatigue, the effects were mediated by stress. A decrease in stress, in addition, was associated with a clinically meaningful decrease in fatigue. These results suggest that perceived stress plays an important role in SLE fatigue and may be an important focus of interventions for fatigue.

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“…SLE has a profound impact on the quality of life through reduced physical functioning, effects on mental and cognitive health, and work productivity [2]. Fatigue is an important factor influencing patients' daily life independent of disease activity [3]. SLE affected women of childbearing age are about nine times more frequent than men [4].…”

Section: Introductionmentioning

confidence: 99%

Living with Systemic Lupus Erythematosus: A Profile of Young Female Patients

Macejová

Gecková

Husárová

et al. 2020

IJERPH

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The aim is to describe a profile of systemic lupus erythematosus (SLE) patient (socio-demographic data, course of disease, health status, and health care utilization, SLE impact on their life, SLE awareness) and to explore the association of patient’s perspective with clinical indicators. Adult patients diagnosed by SLE were recruited in outpatient clinics (n = 76, 88% female, data collected in 2012–2016, Slovakia). The association of patients’ perspective (SLE status, health complaints during remission, SLE impact, hospitalizations) with clinical activity (European Consensus Lupus Activity Measurement Index—ECLAM) and inflammatory marker (erythrocyte sedimentation rate—ESR) was assessed by t-test for independent variables and one-way ANOVA. Almost 17.9% of patients reported relapse. During remission, they mostly suffered fatigue and pain. Nearly all patients were on chronic pharmacological treatment. Most of the patients assessed SLE impact on their life as restrictive (56.9%) or very restrictive (23.1%). The most frequent source of information was their physician, and 67.2% reported that they have sufficient information about the disease and its treatment. Only the association of SLE status and hospitalization with clinical activity (ECLAM) and inflammatory marker (ESR) were confirmed. With recent improvements in diagnostics and therapy options, the prognosis for patients with SLE has improved. Nevertheless, the impact of this disease on all areas of a patient’s life is extensive.

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Fatigue in systemic lupus erythematosus

Abstract: Fatigue is an important factor influencing patient daily life independent from disease activity in our study. The SLE patients with severe fatigue should also be assessed for other possible underlying causes such as anxiety, depression and poor quality of life.

Cited by 28 publications

References 40 publications

Fatigue of systemic lupus erythematosus in China: contributors and effects on the quality of life

Fatigue of systemic lupus erythematosus in China: contributors and effects on the quality of life

Longitudinal Study of Fatigue, Stress, and Depression: Role of Reduction in Stress Toward Improvement in Fatigue

Living with Systemic Lupus Erythematosus: A Profile of Young Female Patients

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