Fatigue in rheumatoid arthritis and its relation to interleukin-6 serum level

Helal, Ahmed; Shahine, Enas M.; Hassan, Mohamed; Hashad, Doaa; Moneim, Riham Abdel

doi:10.1016/j.ejr.2012.08.004

Cited by 16 publications

(11 citation statements)

References 22 publications

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“…This study showed high significance increase in blood serum pro-inflammatory cytokine IL-6 concentrations These results coincide with the studies of (7,17) ; they found significant increase of blood serum IL-6in rheumatoid arthritis patients in comparison with control group. Interleukin-6 (IL-6) is a pleiotropic cytokine with multiple functions in different pathophysiologic systems, including rheumatoid arthritis (RA) (18) .…”

Section: Resultssupporting

confidence: 91%

“…Ig synthesis is also regulated by IL-6, which induces the differentiation of activated B cells into Ig-producing plasma cells and promotes the differentiation of T follicular helper cells (5) .During autoimmunity (including RA) and inflammatory disorders, IL-6 stimulates hepatocytes in the liver, resulting in the production of acute phase proteins such as CRP, serum amyloid A, fibrinogen; as a result, acute phase proteins such as CRP are often used as biomarkers of inflammation (6) . ThusInterleukin 6 (IL-6) is one of the cytokines which play a significant role in RA pathogenesis (7) .…”

Section: Introductionmentioning

confidence: 99%

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Immunological, Physiological, Andbiochemical Study of Some Patients With Rheumatoid Arthritis in Kirkuk City

Al-Izzi¹,

Al-Hashim²,

Riga³

2020

ATMPH

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This study was designed in order to estimate some immunological (IL-6 and C-Reactive Protein -CRP-), physiological (Resistin) and biochemical (Glutathione and Malondialdehyde) parameters of some patients with rheumatoid arthritis in Kirkuk city. The study involved (60) blood samples were divided into 2 groups: group one: adult normal healthy individuals as control group, group two: adult patients with rheumatoid arthritis. The results of this study found significant increase inpro-inflammatory cytokine IL-6 concentrations at levels (P≤ 0.05) of second group in comparison with control group ; and there are significant increases in adipokineresistinconcentrations at levels (P≤ 0.05) of second group in comparison with control group; and there are significant increases in CRP concentrations at levels (P≤ 0.05) of second group in comparison with control group and there are significant decreases in glutathione (GSH) concentrations at levels (P≤ 0.05) of second group in comparison with control group, and there are significant increases in malondialdehyde (MDA) concentrations at levels (P≤ 0.05) of second group in comparison with control group.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Immunological, Physiological, Andbiochemical Study of Some Patients With Rheumatoid Arthritis in Kirkuk City

Al-Izzi¹,

Al-Hashim²,

Riga³

2020

ATMPH

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“…Fatigue in Rheumatoid arthritis is a common complaint which exerts immense burden over the person's life, impairs the quality of living and incur huge financial losses. Abdel Moneim H. Helal et al 11 in case control study found that fatigue is more prevalent in RA patients who had raised serum levels of interleukin-6, independent Abrar Ahmed Wagan et al of disease duration and activity. In our study results we found there was direct relationship between disease activity and fatigue score, Dhir et al also reported same it is significantly associated with high DAS28 scores.…”

Section: Discussionmentioning

confidence: 96%

Fatigue assessment by FACIT-F scale in Pakistani cohort with Rheumatoid Arthritis (FAF-RA) study

Wagan¹,

Raheem²,

Bhatti³

et al. 2021

Pak J Med Sci

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Objective: To fine out fatigue frequency and severity by FACIT-F scale in Pakistani cohort with rheumatoid arthritis. Methods: This study was conducted at department of Medicine division of rheumatology CPMC Lahore. After the approval of IRB, 192 patients of RA were recruited. Written, informed consent was taken, demographic details were noted, patients filled the URDU version of FACIT-F (fatigue severity scale). 5-ml of blood was taken for fasting blood sugar, viral markers and ESR by a trained phlebotomist. Each individual’s disease activity was assessed by DAS-28 and FACIT-F score was calculated. Results: The Mean age (39.9±10.5) years, (71.9%) were females. Fatigue frequency was 62% (n=126), age, education, hypertension, DAS-28, exercise levels and HCV gives significant association with fatigue score. Linear regression analysis, results showed one unit increase in DAS-28 will gives 2.71 unit increases in fatigue scores(P <0.05). Conclusions: We have very high frequency of fatigue in RA, increases with disease activity & associated conditions. doi: https://doi.org/10.12669/pjms.37.4.3602 How to cite this:Wagan AA, Raheem A, Bhatti A, Zafar T. Fatigue assessment by FACIT-F scale in Pakistani cohort with Rheumatoid Arthritis (FAF-RA) study. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.3602 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…En un trabajo publicado recientemente, los autores hallaron correlación positiva de IL-6 en suero con parámetros de actividad de la enfermedad como VSG, PCR y DAS28, y con distintos autoanticuerpos como los anti-CCP y anti-vimentina mutada citrulinada 38 . Concordantemente, otros grupos hallaron correlación positiva entre IL-6 y PCR 8,56 . Si bien en el trabajo de Abdel Mequid y col no obtuvieron correlación entre esas 2 variables, ellos hallaron correlación positiva de IL-6 con VSG y anti-CCP 45 .…”

Section: Comparación De Los Niveles Séricos De Il-22 E Il-6 Entre Pacientes Con Ar Y Controlesunclassified

Serum levels of Interleukin 22 and Interleukin 6 decrease after treatment in patients with rheumatoid arthritis

Ferreira

Alamino

Acosta

et al. 2020

Rev. Argent. Reumatol.

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Introduction: Rheumatoid arthritis is characterized by synovium inflammation due to the infiltration of immune cells that secrete Th17 cytokines like IL-22 and IL-6. The dynamics of these cytokines during the treatment remain unknown. The aim of this study was to evaluate the levels of IL-22 and IL-6 serum and synovial fluid (SF) in correlation with different biochemical and clinical parameters and treatment-associated changes. Material and methods: Seventy-seven RA patients and 30 controls were recruited. Thirty patients were evaluated after 3 months of treatment and SF was collected of 12 patients. ESR, CRP, RF, anti-CCP hs, IL-22 e IL-6 were measured. DAS28 was used to assess disease activity and response to treatment followed EULAR criteria. Results: There were not differences in serum IL-22 and IL-6 levels between patients and controls. Cytokine levels decreased after treatment, mainly in responder patients. IL-22 was decreased and IL-6 was increased in SF compared to serum. IL-6 correlated positively with CRP and anti-CCPhs. ESR, CRP and DAS28 were increased in patients with detectable IL-6 compared to those with undetectable IL-6. Conclusion: In patients with detectable serum IL-22 and IL-6 levels before treatment initiation, follow-up of cytokine levels could be an useful additional tool to evaluate treatment response.

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Fatigue in rheumatoid arthritis and its relation to interleukin-6 serum level

Cited by 16 publications

References 22 publications

Immunological, Physiological, Andbiochemical Study of Some Patients With Rheumatoid Arthritis in Kirkuk City

Immunological, Physiological, Andbiochemical Study of Some Patients With Rheumatoid Arthritis in Kirkuk City

Fatigue assessment by FACIT-F scale in Pakistani cohort with Rheumatoid Arthritis (FAF-RA) study

Serum levels of Interleukin 22 and Interleukin 6 decrease after treatment in patients with rheumatoid arthritis

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