Fatigue in ovarian carcinoma patients

Holzner, Bernhard; Kemmler, Georg; Meraner, Verena; Maislinger, Andrea; Kopp, Martin; Bodner, Thomas; Nguyen-Van-Tam, Dominic P.; Zeimet, Alain G.; Fleischhacker, W. Wolfgang; Sperner‐Unterweger, Barbara

doi:10.1002/cncr.11253

Cited by 92 publications

(63 citation statements)

References 47 publications

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“…Nevertheless, this study also confirmed that the QoL improves with ongoing treatment and continues to get better after the end of CT, reaching a level similar to that of the general female population [17,18]. The authors underlined the importance of longitudinal assessment of QoL in order to facilitate the identification of symptom burden in EOC patients.…”

Section: Discussionsupporting

confidence: 61%

Sexual Health and Quality of Life Assessment among Ovarian Cancer Patients during Chemotherapy

Domenici¹,

Palaia²,

Giorgini³

et al. 2016

Oncology

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Background: During the last decades many successful efforts have been made in order to increase life expectancy in ovarian cancer (OC) patients. However, just a few studies have investigated the impact of OC on quality of life (QoL) and sexual function in OC cases during treatment. Objective: The aim of this study was to evaluate the QoL and sexual function of OC patients during chemotherapy (CT). Patients and Methods: Forty-nine subjects were enrolled and filled in the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-OV28, Female Sexual Function Index (FSFI) and Female Sexual Distress Scale (FSDS) questionnaires. The results were evaluated globally and consequently stratified into several groups: single surgery versus multiple surgeries, age ≤48 years versus >48 years, and first-line CT versus multiple lines of CT. Results: Menopause-related symptoms, body image and attitude toward the disease were significantly worse during first-line CT (p = 0.018, p = 0.029 and p = 0.006, respectively). Sexual outcomes resulted in better scores in younger patients in all questionnaires (FSFI: p = 0.001; FSDS: p = 0.048; specific EORTC QLQ-OV28 items: p = 0.022). Scores concerning body image, attitude toward the disease and CT-associated symptoms resulted worse in patients after the first surgery (p = 0.017, p = 0.002 and p = 0.012, respectively). Conclusion: Our study confirms that OC has a detrimental impact on QoL and intimacy, particularly in younger patients, during the first course of CT and after the first cytoreductive surgery.

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Section: Discussionsupporting

confidence: 61%

Sexual Health and Quality of Life Assessment among Ovarian Cancer Patients during Chemotherapy

Domenici¹,

Palaia²,

Giorgini³

et al. 2016

Oncology

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“…It is a common effect of chemotherapy including platinum and taxane agents, but surgical recovery, malnutrition, depression, anemia, and the cancer itself may also be factors [46,50]. Fatigue may last long after primary treatment and is discussed further below.…”

Section: Fatiguementioning

confidence: 97%

Quality-of-Life Issues in the Management of Epithelial Ovarian Cancer

Lowe

Ferrell

Leong

2007

Curr. Treat. Options in Oncol.

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The importance of quality-of-life (QOL) measurements in cancer management is being increasingly appreciated. This is especially important in patients with advanced cancers. Over 80% of women with epithelial ovarian cancer (EOC) will present with disease outside the ovary as there are no accurate screening tests, and symptoms usually do not develop until EOC has spread. Standard treatment includes debulking surgery followed by chemotherapy to which most women will have a complete response but only a minority of women with advanced disease will be cured. Fortunately, advances in surgical and chemotherapeutic management have improved overall survival with 45% of women of all stages living 5 years or longer. EOC may in many cases be considered a "chronic cancer," which highlights the importance of QOL in management decisions. QOL may be affected by the disease itself as well as by surgical and chemotherapeutic treatments. Future studies of the care and treatment of EOC patients should include well-designed QOL evaluations.

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“…Oncologist ® Studies in patients with a range of cancer diagnoses have reported the expected negative correlation between the incidence of CRF and patients' QoL [7,36,[45][46][47][48]. In their study of fatigue, psychological distress, and functional status among women receiving radiotherapy for uterine cancer, Ahlberg and coworkers found highly statistically significant negative correlations between general fatigue and multiple domains of QoL, including physical, role, emotional, cognitive, and social functioning (all p < .001, except social functioning p = .002) [36].…”

Section: Thementioning

confidence: 99%

Cancer-Related Fatigue: The Scale of the Problem

et al. 2007

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Fatigue is one of the most common and debilitating symptoms experienced by patients with cancer. Cancer-related fatigue (CRF) is characterized by feelings of tiredness, weakness, and lack of energy, and is distinct from the "normal" drowsiness experienced by healthy individuals in that it is not relieved by rest or sleep. It occurs both as a consequence of the cancer itself and as a side effect of cancer treatment, although the precise underlying pathophysiology is largely unknown. CRF may be an early symptom of malignant disease and is reported by as many as 40% of patients at diagnosis. Virtually all patients expect fatigue from cancer therapy. Up to 90% of patients treated with radiation and up to 80% of those treated with chemotherapy experience fatigue. CRF continues for months and even years following completion of treatment in approximately one third of the patients with cancer. The impact of CRF on a patient's quality of life (QoL), particularly in relation to physical functioning and the ability to perform activities of daily living, is both profound and pervasive. In addition, CRF is associated with considerable psychological distress and can impose a significant financial burden by limiting a patient's ability to work. These effects can extend to caregivers and family members, who may also have to reduce their working capacity in order to provide additional care for a patient with CRF. This paper examines the prevalence of CRF and explores the impact of this distressing symptom on patients' functioning and QoL. The Oncologist 2007;12(suppl 1):4-10

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Fatigue in ovarian carcinoma patients

Cited by 92 publications

References 47 publications

Sexual Health and Quality of Life Assessment among Ovarian Cancer Patients during Chemotherapy

Sexual Health and Quality of Life Assessment among Ovarian Cancer Patients during Chemotherapy

Quality-of-Life Issues in the Management of Epithelial Ovarian Cancer

Cancer-Related Fatigue: The Scale of the Problem

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