2019
DOI: 10.1177/1352458519851247
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Fatigue in multiple sclerosis: The role of thalamus

Abstract: Fatigue is very common in multiple sclerosis (MS) and is often considered as its most disabling symptom. Over the last 20 years, an increasing number of studies have evaluated the pathogenetic bases of MS-related fatigue. Converging evidence from neurophysiology and neuroimaging research suggests that a dysfunction in a cortico-subcortical pathway, centered on thalamus, is involved in the pathogenesis of fatigue. However, type and significance of such dysfunction remain unknown, and some studies reported an in… Show more

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Cited by 62 publications
(34 citation statements)
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“…They showed a significant change of the early component of HFOs, reflecting the possible primary role played by the thalamus in the pathogenesis of MS-related fatigue, while the latter component reflects that the cortico-cortical network activity in the somatosensory cortex was not modified significantly. Furthermore, increasing evidence from neuroimaging studies is supporting the hypothesis that the thalamus is a key player in fatigue generation (6).…”
Section: Neurophysiology As Investigating Tool For the Pathogenic Mecmentioning
confidence: 97%
See 2 more Smart Citations
“…They showed a significant change of the early component of HFOs, reflecting the possible primary role played by the thalamus in the pathogenesis of MS-related fatigue, while the latter component reflects that the cortico-cortical network activity in the somatosensory cortex was not modified significantly. Furthermore, increasing evidence from neuroimaging studies is supporting the hypothesis that the thalamus is a key player in fatigue generation (6).…”
Section: Neurophysiology As Investigating Tool For the Pathogenic Mecmentioning
confidence: 97%
“…Fatigue is a complex symptom involving both cognitive and motor domains and multiple factors, in addition to sensorimotor dysfunction as assessed by EEG and EPs, which can contribute to its pathogenesis and/or exacerbate its manifestations (demographics, comorbidity, genetics, diet, exercise, depression, cognitive impairment, pain, and sleep disorders) (6). Neurophysiology can also play an important role in defining and quantifying some of these factors.…”
Section: Neurophysiology As Investigating Tool For the Pathogenic Mecmentioning
confidence: 99%
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“…M ultiple sclerosis (MS) is a chronic debilitating disease of the CNS. Atrophy of subcortical gray matter structures (SGMS) is associated with cognitive dysfunction, fatigue, and overall disability in MS. 1 Among all SGMS, most attention is riveted on the thalamus, a gateway for cortical areas and a relay between the cortex and basal ganglia. 2 Volumetric MR imaging studies showed thalamic atrophy at early stages of the disease, including clinically and radiologically isolated syndromes.…”
mentioning
confidence: 99%
“…In other words, fatigue is affected by the influence of pro-inflammatory cytokines, central nervous system lesion load, cortical atrophy, abnormal patterns of cerebral activation, poor endocrine influences, and axonal injury that make it difficult to recognize their mechanisms. 52 Besides, muscle fatigue has been observed in MS patients 25 and may contribute to the overall fatigue reported by individuals with MS. Thus, this lack of clarity related to fatigue in MS makes it hard to understand the potential mechanisms by which MT may have a positive impact on fatigue.…”
Section: Discussionmentioning
confidence: 99%