Fatigue in multiple sclerosis: associations with health‐related quality of life and physical performance

Smedal, Tori; Beiske, Antonie Giæver; Glad, S.; Myhr, Kjell–Morten; Aarseth, Jan Harald; Svensson, Elisabeth; Gjelsvik, Bente E. Bassøe; Strand, Liv Inger

doi:10.1111/j.1468-1331.2010.03090.x

Cited by 25 publications

(21 citation statements)

References 36 publications

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“…A review of studies on depression in people with MS found that lifetime prevalence rates of about 40–50% and 12-month prevalence rates of around 20% are commonly reported [48]. Fatigue is known to be one of the most debilitating, but poorly understood symptoms of MS [36]. Our data indicate that a significant proportion of MS participants have clinically significant fatigue, but the median overall score was lower than that reported with another large cohort [38].…”

Section: Discussionmentioning

confidence: 99%

“…The fatigue severity scale (FSS) consists of nine fatigue-related statements rated on a seven-point scale from “disagree” to “agree” [18]. It has good internal consistency, stability, and sensitivity to change over time and is frequently used to assess fatigue in MS populations [29, 36]. A mean score ≥ 4 has been suggested as a cutoff to indicate clinically significant fatigue and has been used in several other studies [36–38].…”

Section: Methodsmentioning

confidence: 99%

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Methodology of an International Study of People with Multiple Sclerosis Recruited through Web 2.0 Platforms: Demographics, Lifestyle, and Disease Characteristics

Hadgkiss

Jelinek

Weiland

et al. 2013

Neurology Research International

102

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Background. Despite evidence of the potential importance of the role of health and lifestyle behaviours in multiple sclerosis (MS) outcomes, there has not been a significant focus on this area of research. Aim. We aimed to recruit an international sample of people with MS at baseline and over a five-year timeframe, examine their health and lifestyle behaviours, and determine the relationship of these behaviours to self-reported disability, disease activity, and quality of life. Methods. People with MS were recruited through web 2.0 platforms including interactive websites, social media, blogs, and forums and completed a comprehensive, multifaceted online questionnaire incorporating validated and researcher-derived tools. Results. 2519 participants met inclusion criteria for this study. This paper describes the study methodology in detail and provides an overview of baseline participant demographics, clinical characteristics, summary outcome variables, and health and lifestyle behaviours. The sample described is unique due to the nature of recruitment through online media and due to the engagement of the group, which appears to be well informed and proactive in lifestyle modification. Conclusion. This sample provides a sound platform to undertake novel exploratory analyses of the association between a variety of lifestyle factors and MS outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Methodology of an International Study of People with Multiple Sclerosis Recruited through Web 2.0 Platforms: Demographics, Lifestyle, and Disease Characteristics

Hadgkiss

Jelinek

Weiland

et al. 2013

Neurology Research International

102

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“…These findings demonstrate the significant and broad range of health and lifestyle factors associated with fatigue, including MS Disease Steps and reduced walking activity, and build on previous studies that have found that people with MS identify fatigue as a contributing factor to their falls 8,9 and reduced quality of life. 27,28 People with MS rate walking as one of the most important bodily functions and state that mobility is the in the 6-month follow-up period. Of those who fell, 32 (25%) fell one time, 25 (20%) fell twice, and 69 (55%) fell three times or more.…”

Section: Discussionmentioning

confidence: 99%

Fatigue, Physical Activity, Quality of Life, and Fall Risk in People with Multiple Sclerosis

Vister¹,

Tijsma²,

Hoang³

et al. 2017

International Journal of MS Care

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“…Indeed, fatigue is one of the most common symptoms of MS, occurring in about 80% of people, and may be the most prominent symptom in people who otherwise have minimal activity limitations [10, 18], significantly interfering with a person's quality of life [40, 41]. Interestingly, while the MS group had mild disability on the EDSS scale, their score on the BI (while being relatively high) was significantly lower than the healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

The Role of Clinical and Instrumented Outcome Measures in Balance Control of Individuals with Multiple Sclerosis

Kanekar

Aruin

2013

Multiple Sclerosis International

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Purpose. The aim of the study was to investigate differences in balance control between individuals with multiple sclerosis (MS) and healthy control subjects using clinical scales and instrumented measures of balance and determine relationships between balance measures, fatigue, and disability levels in individuals with MS with and without a history of falls. Method. Twelve individuals with MS and twelve healthy controls were evaluated using the Berg Balance and Activities-specific Balance Confidence Scales, Modified Clinical Test of Sensory Interaction on Balance, and Limits of Stability Tests as well as Fatigue Severity Scale and Barthel Index. Results. Mildly affected individuals with MS had significant balance performance deficits and poor balance confidence levels (P < 0.05). MS group had higher sway velocities and diminished stability limits (P < 0.05), significant sensory impairments, high fatigue and disability levels (P < 0.05). Sway velocity was a significant predictor of balance performance and the ability to move towards stability limits for the MS group. For the MS-fallers group, those with lower disability levels had faster movement velocities and better balance performance. Conclusion. Implementation of both clinical and instrumented tests of balance is important for the planning and evaluation of treatment outcomes in balance rehabilitation of people with MS.

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Fatigue in multiple sclerosis: associations with health‐related quality of life and physical performance

Abstract: fatigue was associated with HRQoL at baseline. Improvement in fatigue seemed to be related to other factors than improvement in physical performance. A broader strategy including both physical and psychological dimensions seems to be needed to improve fatigue over the long-term.

Cited by 25 publications

References 36 publications

Methodology of an International Study of People with Multiple Sclerosis Recruited through Web 2.0 Platforms: Demographics, Lifestyle, and Disease Characteristics

Methodology of an International Study of People with Multiple Sclerosis Recruited through Web 2.0 Platforms: Demographics, Lifestyle, and Disease Characteristics

Fatigue, Physical Activity, Quality of Life, and Fall Risk in People with Multiple Sclerosis

The Role of Clinical and Instrumented Outcome Measures in Balance Control of Individuals with Multiple Sclerosis

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