Fatigue in hypokinetic, hyperkinetic, and functional movement disorders

Vico, Ilaria Antonella Di; Cirillo, Giovanni; Tessitore, Alessandro; Siciliano, Mattia; Venturelli, Massimo; Falup‐Pecurariu, Cristian; Tedeschi, Gioacchino; Morgante, Francesca; Tinazzi, Michèle

doi:10.1016/j.parkreldis.2021.03.018

Cited by 14 publications

(13 citation statements)

References 72 publications

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“…Patients with PSP not only have motor symptoms but also exhibit various non-motor symptoms (NMS), such as cognitive decline, urinary symptoms, emotional problems, and fatigue 2 . Fatigue is a disabling symptom in various movement disorders including Parkinson's disease (PD), and studies showed that fatigue significantly affects the patients' quality of life (QoL) [3][4][5] . Several studies have investigated NMS including fatigue in patients with PSP and reported that sleep/fatigue problems are common in these patients, with a prevalence of 82.9-100% 2,6-9 .…”

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confidence: 99%

“…Generally, fatigue is described as an overwhelming feeling of tiredness and exhaustion occurring in the context of various neurological diseases 3 . Fatigue has been inconsistently used in previous studies, and it is difficult to define fatigue because it is subjective and various factors such as mood disorders, sleep disorders, orthostatic hypotension, and anemia can affect fatigue 4,5 .…”

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confidence: 99%

“…Specialized studies focused on fatigue and investigation of its clinical impact are needed to improve the understanding and management of this disabling symptom. Herein, we investigated fatigue in patients with probable PSP using the Parkinson Fatigue Scale (PFS), which is a specialized scale for assessing fatigue 5 . Moreover, we also investigated the associated clinical features, including other NMSs.…”

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confidence: 99%

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Understanding fatigue in progressive supranuclear palsy

Ahn

Song

Lee

et al. 2021

Sci Rep

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Fatigue is a common and disabling non-motor symptom (NMS) of Parkinson’s disease (PD); however, it has been poorly understood in patients with progressive supranuclear palsy (PSP). We investigated the association between fatigue, clinical features, and other NMS in patients with probable PSP. In 72 probable PSP patients, fatigue was investigated using the Parkinson Fatigue Scale (PFS). Further, all patients were evaluated using the PSP rating scale (PSPRS), Beck Depression Inventory (BDI), Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), PD Sleep Scale (PDSS), NMS scale (NMSS), PD Questionnaire-39 summary index (PDQ-39 SI), and Scale for outcomes in PD-Autonomic (SCOPA-AUT). The prevalence of fatigue assessed by PFS was 38.9% (28/72) in patients with PSP. The secondary fatigue was defined as fatigued patients with depression and/or sleep disturbances. We divided the patients into primary (n = 15), secondary (n = 13), and non-fatigue groups. There were no differences in age, sex, disease duration, and PSPRS, PDSS, MMSE, and FAB scores among the three groups. The primary fatigue group had higher scores in PDQ-39 SI compared to the non-fatigue group. The secondary fatigue group showed higher scores in NMSS, PDQ-39 SI, and SCOPA-AUT compared to the non-fatigue group. PFS was positively correlated with NMSS and PDQ-39 SI and SCOPA-AUT. Fatigue is common in patients with PSP and is associated with the NMS and the quality of life in these patients. The present study provides meaningful insight into fatigue in patients with PSP.

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Understanding fatigue in progressive supranuclear palsy

Ahn

Song

Lee

et al. 2021

Sci Rep

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“…The importance of studying PMF has also been underlined in studies demonstrating an association between pathological fatigue, a frequent and disabling symptom common to many neurological diseases ( Kluger et al, 2013 ; Di Vico et al, 2021 ) and lack of PMF patients affected by multiple sclerosis ( Morgante et al, 2011 ). Moreover, reduced suppression and increased facilitation of corticospinal excitability prior to movement onset in post-stroke highly fatigued patients indicates poor modulation of pre-movement excitability which may in turn reflect poor sensory processing ( De Doncker et al, 2021 ), supporting the sensory attenuation model of fatigue ( Kuppuswamy, 2017 ).…”

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confidence: 99%

Changes in Corticospinal Circuits During Premovement Facilitation in Physiological Conditions

Cirillo

Vico

Andani

et al. 2021

Front. Hum. Neurosci.

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Changes in corticospinal excitability have been well documented in the preparatory period before movement, however, their mechanisms and physiological role have not been entirely elucidated. We aimed to investigate the functional changes of excitatory corticospinal circuits during a reaction time (RT) motor task (thumb abduction) in healthy subjects (HS). 26 HS received single pulse transcranial magnetic stimulation (TMS) over the primary motor cortex (M1). After a visual go signal, we calculated RT and delivered TMS at three intervals (50, 100, and 150 ms) within RT and before movement onset, recording motor evoked potentials (MEP) from the abductor pollicis brevis (APB) and the task-irrelevant abductor digiti minimi (ADM). We found that TMS increased MEPAPB amplitude when delivered at 150, 100, and 50 ms before movement onset, demonstrating the occurrence of premovement facilitation (PMF). MEP increase was greater at the shorter interval (MEP50) and restricted to APB (no significant effects were detected recording from ADM). We also reported time-dependent changes of the RT and a TMS side-dependent effect on MEP amplitude (greater on the dominant side). In conclusion, we here report changes of RT and side-dependent, selective and facilitatory effects on the MEPAPB amplitude when TMS is delivered before movement onset (PMF), supporting the role of excitatory corticospinal mechanisms at the basis of the selective PMF of the target muscle during the RT protocol.

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“…Previous cross-sectional studies reported that a wide range of factors are associated with fatigue in PD. However, the results are inconsistent because they infuence each other over the course of disease progression [1][2][3][4][5][6][7]. A few longitudinal studies have been tried for a better understanding and to fgure out the predictors of fatigue [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Orthostatic Hypotension Is a Predictor of Fatigue in Drug-Naïve Parkinson’s Disease

Ahn

Cho

Youn

2023

Parkinson's Disease

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Introduction. Fatigue and orthostatic hypotension (OH) are common and disabling nonmotor symptoms (NMSs) of Parkinson’s disease (PD), but none of the studies have reported on the longitudinal association between fatigue and OH. Methods. Drug-naïve PD patients were recruited from a hospital-based cohort and evaluated with the Parkinson Fatigue Scale (PFS), head-up tilt test, Unified PD Rating Scale, Hoehn and Yahr stage, Montreal Cognitive Assessment, Scale for Outcomes in PD-Autonomic (SCOPA-AUT), Beck Depression Inventory (BDI), Beck Anxiety Inventory, PD Sleep Scale, and medications at the baseline and follow-up visits. Results. A total of 80 patients were included, and the mean ages were 66.6 and 63.8 years in the fatigue and nonfatigue groups, respectively. The prevalence of fatigue was 17.5% (14/80) at the baseline and follow-up (mean follow-up: 23.3 ± 9.9 months). The prevalence of OH in the fatigue group was 57.1%, and it was significantly higher than that of the nonfatigue group. Six of the 14 patients (42.9%) in the fatigue group had persistent fatigue at the follow-up, and eight of them (57.1%) converted to the nonfatigue group. Logistic regression analysis demonstrated that the changes of BDI and the presence of OH at the baseline were the predictors for fatigue in drug-naïve PD. Conclusion. Fatigue is a common NMS in PD but can vary depending on the disease course. OH and depression are the most relevant predictors for the development of fatigue in drug-naïve PD. The present study suggests that the management of autonomic symptoms and depression might be helpful for managing fatigue in PD.

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Fatigue in hypokinetic, hyperkinetic, and functional movement disorders

Cited by 14 publications

References 72 publications

Understanding fatigue in progressive supranuclear palsy

Understanding fatigue in progressive supranuclear palsy

Changes in Corticospinal Circuits During Premovement Facilitation in Physiological Conditions

Orthostatic Hypotension Is a Predictor of Fatigue in Drug-Naïve Parkinson’s Disease

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