Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network

Ifesemen, Onosi Sylvia; McWilliams, Daniel F.; Norton, Sam; Kiely, Patrick; Young, Adam; Walsh, David A.

doi:10.1093/rheumatology/keab947

Cited by 9 publications

(10 citation statements)

References 46 publications

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“…28,29 Previous studies show the prevalence of fatigue in RA is about 44.00%-71.25% and the fatigue score in RA patients is higher than in healthy controls, indicating that fatigue is widespread among RA patients. [30][31][32] Similar to these studies, our study presented that the fatigue scores reflected by BRAF-MDQ and BFI-C scale were increased in RA patients compared with healthy controls. The possible reasons for fatigue in RA patients were as follows: (1) RA patients had high levels of inflammation, which was considered to be positively correlated with fatigue.…”

Section: Discussionsupporting

confidence: 84%

Fatigue in rheumatoid arthritis patients: The status, independent risk factors, and consistency of multiple scales

Zhou,

Wang,

Gao

et al. 2024

Immunity Inflam & Disease

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IntroductionFatigue is a common symptom that negatively affects the outcomes and functions of rheumatoid arthritis (RA) patients. This study aimed to assess the fatigue by two scales and validate their consistency, also to comprehensively evaluate fatigue‐related risk factors in RA patients.MethodsIn this case–control study, the fatigue of 160 RA patients and 60 healthy controls was evaluated by the Bristol Rheumatoid Arthritis Fatigue Multi‐Dimensional Questionnaire (BRAF‐MDQ) and the Chinese version of the Brief Fatigue Inventory (BFI‐C). The 28‐joint disease activity score using erythrocyte sedimentation rate of RA patients was assessed.ResultsThe BRAF‐MDQ and BFI‐C scores were elevated in RA patients versus healthy controls (all p < .001). Interestingly, BRAF‐MDQ global fatigue score positively correlated with BFI‐C global fatigue score in both RA patients (r = .669, p < .001) and healthy controls (r = .527, p < .001); meanwhile, Kendall's tau‐b test showed a high consistency between BRAF‐MDQ and BFI‐C global fatigue scores in RA patients (W = 0.759, p < .001) and healthy controls (W = 0.933, p < .001). Notably, higher education level (В = −4.547; 95% confidence interval: −7.065, −2.029; p < .001) and swollen joint count (В = 1.965; 95% confidence interval: 1.375, 2.554; p < .001) independently related to BRAF‐MDQ global fatigue score; higher education level (В = −0.613; 95% confidence interval: −0.956, −0.269; p = .001) and clinical disease activity index (В = 0.053; 95% confidence interval: 0.005, 0.102; p = .032) independently linked with BFI‐C global fatigue score.ConclusionFatigue commonly occurs in RA patients, which independently relates to education level and disease activity. Furthermore, BRAF‐MDQ and BFI‐C scales exhibit a high consistency in assessing fatigue.

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Section: Discussionsupporting

confidence: 84%

Fatigue in rheumatoid arthritis patients: The status, independent risk factors, and consistency of multiple scales

Zhou,

Wang,

Gao

et al. 2024

Immunity Inflam & Disease

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“…There was a high fatigue prevalence in patients with psoriatic arthritis, similar to patients with rheumatoid arthritis as well as ankylosing spondylitis [24,25].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with fatigue in patients with psoriatic arthritis: a systematic review and meta-analysis

Tang,

Chew,

Fong

2024

Preprint

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Objectives: Fatigue is a prominent symptom in patients with psoriatic arthritis (PsA). There was a wide variety of statistics previously reported on fatigue prevalence in patients. This systematic review examined the current literature to derive the overall prevalence of fatigue and risk factors in PsA patients. Methods: A systematic review of the literature with subsequent meta-analyses was conducted. Publications assessing fatigue severity and prevalence in patients with PsA using validated measurement scores were identified from seven online databases (Cochrane, CINAHL, EMBASE, Google Scholar, MEDLINE, PubMed, and Web of Science), from inception until April 2023. Employing a random effects model, we calculated the pooled fatigue prevalence. Quality assessment of included studies was performed utilising the Joanna Briggs Critical Appraisal Tool. Results: The final analysis included 15 studies with 6482 PsA patients. Pooled fatigue prevalence was 0.51 (95% CI: 0.41, 0.61; I2 = 97.4%). There was substantial heterogenicity across the studies, with biologics use and geographical location in terms of Western versus Eastern countries being possible sources of heterogeneity. Age, disease duration, gender, tender joint count, swollen joint and enthesitis count are among the most commonly reported risk factors for fatigue in multivariate logistic regressions. Conclusions: Approximately half of the patients with PsA experienced fatigue. Biologics use and geographical location of the study were possible sources of heterogeneity in the subgroup analysis.

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“…Ifesmen et al [ 42 ] studied the influence of various factors on the intensity of fatigue in RA patients for three years in a group of 1236 patients (at the beginning of the study, after six months, and then every year). Of the determinants tested, only female gender, poor mental health, pain, higher Health Assessment Questionnaire, and the number of tender joints were significantly associated with vitality (as measured by the SF-36 Vitality score) in a multiple regression analysis.…”

Section: Discussionmentioning

confidence: 99%

The Link between the Demographic and Clinical Factors and Fatigue Symptoms among Rheumatoid Arthritis Patients

Kozłowska

Formanowicz

Bączyk

2022

IJERPH

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Rheumatoid arthritis (RA) is a chronic systemic disease of connective tissue with periods of exacerbation and remission. Fatigue is excessive strain throughout the body that is disproportionate or unrelated to an activity or lifestyle. Fatigue is an integral part of RA in most patients. The study aimed to assess the level of fatigue in RA patients and establish the relationship between fatigue and demographic and clinical factors. The study group consisted of 128 RA patients according to European League Against Rheumatism (EULAR) criteria. The Functional Assessment of Chronic Illness Therapy-Fatigue and -Medical Outcomes Study Short Form 36 (SF-36) vitality scores were used to assess the severity of fatigue symptoms. The analyzed variables were gender, age, disease duration, education, marital status, place of residence, work and residence status, pharmacological treatment, pain, morning stiffness, hemoglobin, C-reactive protein (CRP), rheumatoid factor (RF), compression soreness, Richie Articular Index, and DAS28 disease activity. The examined patients experience chronic fatigue—the mean value on the FACIT-F scale was 24.1 ± 9.1 points and on the SF-36 Vitality score was 14.2 ± 1.8 points. There is a relationship between the level of fatigue and pain, long-lasting morning stiffness, active disease, increased soreness of joints, and low hemoglobin values. When analyzing the symptom of fatigue, each patient should be approached individually, using the existing questionnaires or asking key questions to recognize the situation. The presence of fatigue symptoms should be considered during therapy and patient care by searching for and eliminating additional, intensifying stimuli and increasing its level.

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Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network

Cited by 9 publications

References 46 publications

Fatigue in rheumatoid arthritis patients: The status, independent risk factors, and consistency of multiple scales

Fatigue in rheumatoid arthritis patients: The status, independent risk factors, and consistency of multiple scales

Prevalence and factors associated with fatigue in patients with psoriatic arthritis: a systematic review and meta-analysis

The Link between the Demographic and Clinical Factors and Fatigue Symptoms among Rheumatoid Arthritis Patients

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