Fatigue in chronic obstructive pulmonary disease: a qualitative study of people's experiences

Stridsman, Caroline; Lindberg, Anne; Skär, Lisa

doi:10.1111/scs.12033

Cited by 53 publications

(65 citation statements)

References 43 publications

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“…Dyspnoea thus induces gradual exercise intolerance resulting in physical inactivity, lifestyle change and social isolation 37,38 . The majority of COPD patients are also affected by fatigue 39 . COPD patients commonly experience a cough, which is productive in about 2/3 of cases, defining the so-called bronchitic phenotype of COPD (ref.…”

Section: Clinical Disease Course and Phenotypesmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease: Official diagnosis and treatment guidelines of the Czech Pneumological and Phthisiological Society; a novel phenotypic approach to COPD with patient-oriented care

Koblížek

Chlumský²,

Zindr³

et al. 2013

BIOMED PAP

125

116

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Section: Clinical Disease Course and Phenotypesmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease: Official diagnosis and treatment guidelines of the Czech Pneumological and Phthisiological Society; a novel phenotypic approach to COPD with patient-oriented care

Koblížek

Chlumský²,

Zindr³

et al. 2013

BIOMED PAP

125

116

View full text Add to dashboard Cite

“…1 As a consequence, a marked reduction in strength and endurance of peripheral skeletal muscles has been reported. 2 Besides a lack of exercise stimuli, muscle wasting may also originate from systemic inflammation 3 and corticosteroid therapy.…”

Section: Introductionmentioning

confidence: 99%

Effects of Oxygen Supply During Training on Subjects With COPD Who Are Normoxemic at Rest and During Exercise: A Blinded Randomized Controlled Trial

et al. 2014

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BACKGROUND: It is well established that physical training enhances functionality and quality of life in patients with COPD. However, little data exist concerning the effects of the usefulness of oxygen supply during exercise training for > 3 months in patients with COPD who are normoxemic at rest and during exercise. We hypothesized that oxygen supply during training sessions enables higher training intensity and thus optimizes training results in patients with COPD. METHODS: In this blinded randomized controlled study, we carried out a 24-week training program with progressively increasing loads involving large muscle groups. In addition, we compared the influences of oxygen supplementation. Thirty-six subjects with moderate-to-severe COPD who were not dependent on long-term oxygen therapy trained under supervision for 24 weeks (3 times/week at 30 min/session). Subjects were randomized into 2 groups: oxygen supply via nasal cannula at a flow of 4 L/min and compressed air at the same flow throughout the training program. Lung function tests at rest (inspiratory vital capacity, FEV 1 , Tiffeneau index), cycle spiroergometry (peak ventilation, peak oxygen uptake, peak respiratory exchange rate, submaximal and peak lactic acid concentrations), 6-min walk tests, and quality-of-life assessments (Medical Outcomes Study 36-Item Short Form questionnaire) were conducted before and after 12 and 24 weeks. RESULTS: Independent of oxygen supplementation, statistically significant improvements occurred in quality of life, maximal tolerated load during cycling, peak oxygen uptake, and 6-min walk test after 12 weeks of training. Notably, there were no further improvements from 12 to 24 weeks despite progressively increased training loads. CONCLUSIONS: Endurance training 3 times/week resulted in significant improvements in quality of life and exercise capacity in subjects with moderate-to-severe COPD within the initial 12 weeks, followed by a stable period over the following 12 weeks with no further benefits of supplemental oxygen.

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“…In a study of 1000 patients in an American palliative care programme, fatigue, weakness, and lack of energy were three of the five most frequently reported symptoms with a prevalence of 84%, 66%, and 61%, respectively 1. Fatigue is also commonly reported in non‐cancer patients with progressive life‐threatening diseases, such as multiple sclerosis and .amyotrophic lateral sclerosis,2 chronic obstructive pulmonary disease,3 heart failure,4 HIV,5 as well as chronic heart, kidney, or lung diseases 6, 7. Several drugs, such as the new anti‐neoplastic therapies, or drugs regularly used in palliative care have sedative properties, for example, opioid analgesics, benzodiazepines, antidepressants, or anticonvulsants can cause fatigue 8…”

Section: Introductionmentioning

confidence: 99%

Pharmacological treatments for fatigue associated with palliative care: executive summary of a Cochrane Collaboration systematic review

Mücke

Mochamat

Cuhls

et al. 2016

Journal of Cachexia, Sarcopenia and Muscle

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BackgroundIn palliative care patients, fatigue can be severely debilitating and is often not counteracted with rest, thereby impacting daily activity and quality of life. Further complicating issues are the multidimensionality, subjective nature and lack of a consensus definition of fatigue. The review aimed to evaluate the efficacy of pharmacological treatments for fatigue in palliative care, with a focus on patients at an advanced stage of disease, including patients with cancer and other chronic diseases.MethodsWe considered randomized controlled trials concerning adult palliative care with a focus on pharmacological treatment of fatigue compared with placebo, application of two drugs, usual care or a non‐pharmacological intervention. The primary outcome had to be non‐specific fatigue (or related terms such as asthenia). We searched the CENTRAL, MEDLINE, PsycINFO and EMBASE, and a selection of cancer journals up to 28 April 2014. Two review authors independently assessed trial quality and extracted the data.ResultsWe screened 1645 publications of which 45 met the inclusion criteria. In total, we analysed data from 18 drugs and 4696 participants. There was a very high degree of statistical and clinical heterogeneity in the trials. Meta‐analysis of data was possible for modafinil, pemoline, and methylphenidate.ConclusionsDue to the limited evidence, we cannot recommend a specific drug for the treatment of fatigue in palliative care patients. Some drugs, which may be beneficial for the treatment of fatigue associated with palliative care such as amantadine, methylphenidate, and modafinil, should be further researched.

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Fatigue in chronic obstructive pulmonary disease: a qualitative study of people's experiences

Abstract: Fatigue affects the daily lives of people with COPD. Perceived with dyspnoea, fatigue was described as overwhelming. Most importantly, fatigue seems to be unexpressed to healthcare professionals and relatives.

Cited by 53 publications

References 43 publications

Chronic Obstructive Pulmonary Disease: Official diagnosis and treatment guidelines of the Czech Pneumological and Phthisiological Society; a novel phenotypic approach to COPD with patient-oriented care

Chronic Obstructive Pulmonary Disease: Official diagnosis and treatment guidelines of the Czech Pneumological and Phthisiological Society; a novel phenotypic approach to COPD with patient-oriented care

Effects of Oxygen Supply During Training on Subjects With COPD Who Are Normoxemic at Rest and During Exercise: A Blinded Randomized Controlled Trial

Pharmacological treatments for fatigue associated with palliative care: executive summary of a Cochrane Collaboration systematic review

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