Fatigue in Child Chronic Health Conditions: A Systematic Review of Assessment Instruments

Crichton, Alison; Knight, Sarah; Oakley, Ed; Babl, Franz E; Anderson, Vicki

doi:10.1542/peds.2014-2440

Cited by 60 publications

(70 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A second explanation could be the use of the PedsQL‐MFS for assessing cancer‐related fatigue. Although the PedsQL‐MFS has acceptable psychometric properties, including content validity and internal consistency and responsiveness, there are inconsistent reports regarding known group validity in pediatric cancer . This may hamper the correct identification of patients with important cancer‐related fatigue.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Dijk-Lokkart

Steur

Braam

et al. 2019

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Purpose Cancer‐related fatigue is one of the most distressing side effects of childhood cancer treatment. Physical activity can decrease fatigue and has positive effects on other health outcomes. Most research on physical activity pertains to adults, and the few studies that focus on children have limited follow‐up time. This study evaluates cancer‐related fatigue in children and its association with physical activity over a one‐year time period. Methods Sixty‐eight children with cancer (7–18 years) were recruited during or within the first year after treatment. Physical activity (Actical activity monitor) and cancer‐related fatigue (Pediatric Quality‐of‐Life Questionnaire Multidimensional Fatigue Scale (PedsQL‐MFS), self‐ and parent‐ reports) were assessed at baseline, 4 months, and 12 months. PedsQL‐MFS scores were compared with Dutch norms. Longitudinal association of cancer‐related fatigue with physical activity was evaluated (No. NTR 1531). Results Generally, PedsQL‐MFS scores were worse than norms at baseline and 4 months, and recovered by 12 months except for the parent‐proxy scores in adolescents. Younger children (≤12 years) self‐reported comparable or better scores than norms. Physical activity generally improved over time, but patients mostly remained sedentary. During follow‐up, increased physical activity was associated with less cancer‐related fatigue. Conclusion Cancer‐related fatigue in children improves over time, and increased physical activity is associated with less cancer‐related fatigue. Given the sedentary lifestyle of this population, the positive effect of physical activity on cancer‐related fatigue, and the many other health benefits of an active lifestyle, it is important to stimulate physical activity in childhood cancer patients and survivors.

show abstract

Section: Discussionmentioning

confidence: 99%

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Dijk-Lokkart

Steur

Braam

et al. 2019

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Specific versions are available divided by age groups from 2 to 25 years [33,34], and the instrument has been applied to assess the effects of several conditions and diseases in children, such as cancer [33], sickle cell disease [35] and rheumatology [36]. In a recent systematic review of existing fatigue instruments, the authors concluded that the PedsQL™ Multidimensional Fatigue Scale was the only instrument among those studied with strong evidence of reliability [37]. Reliability and validity have been found to be stable across languages, age and gender [32,38,39].…”

Section: Introductionmentioning

confidence: 99%

Cognitive fatigue in relation to depressive symptoms after treatment for childhood cancer

et al. 2020

View full text Add to dashboard Cite

Background: Cognitive fatigue after childhood cancer is frequently overlooked despite guidelines recommending follow-up, and might be mistaken for depression due to overlapping symptoms. Our objectives were: 1) to examine ratings of fatigue in survivors of paediatric brain tumours (BT) and acute lymphoblastic leukaemia (ALL) compared to healthy controls, 2) to examine the relationship between symptoms of depression and cognitive fatigue, and 3) to evaluate parent-child concordance in ratings of cognitive fatigue. Methods: Survivors of BT (n = 30), survivors of ALL (n = 30), and healthy controls (n = 60) aged 8-18 years completed the Pediatric Quality of Life Multidimensional Fatigue Scale and the Beck Youth Inventories. Associations between cognitive fatigue, diagnosis and depression were assessed with general linear modelling. Group differences were analysed using the Kruskal-Wallis test. Parent-child concordance was investigated with internal consistency reliability. Results: Cognitive fatigue was prevalent in 70% of survivors of BT survivors and in 30% of survivors of ALL. Diagnosis was the main predictor of cognitive fatigue (p < .001, η p 2 = 0.178), followed by depression (p = .010, η p 2 = 0.080). Survivors of BT reported significantly more fatigue than healthy controls on all fatigue subscales. While they also expressed more symptoms of depression, we found no evidence for an interaction effect. Parent-child concordance was moderate to good among survivors, but poor for controls. Conclusions: Survivors of BT and ALL suffer from cognitive fatigue, with survivors of BT expressing more problems. Cognitive fatigue and depression should be assessed in survivors of childhood cancer using both self-rated and proxy-rated measures, and appropriate interventions offered.

show abstract

“…4,5 There is, however, no consensus on one definition of fatigue, and none of the current definitions are specific to perinatal stroke or cerebral palsy (CP). 4,5 There is, however, no consensus on one definition of fatigue, and none of the current definitions are specific to perinatal stroke or cerebral palsy (CP).…”

mentioning

confidence: 99%

“…Indeed, because of its subjective nature, the complexity of the underlying mechanism of fatigue, and its variable impact on function, children with perinatal stroke may describe fatigue in different ways. 4 Increasing understanding about fatigue is important as it may interfere with daily activities, ability to succeed at school, and mobility, as well as compromise independence. Future research, therefore, may benefit from using more comprehensive fatigue assessments in addition to neuropsychological testing, particularly since fatigue in childhood varies with development.…”

mentioning

confidence: 99%

“…Fatigue can be conceptualized as an awareness of imbalance between accessible energy and the cognitive and physical requirements of activities. 4,5 There is, however, no consensus on one definition of fatigue, and none of the current definitions are specific to perinatal stroke or cerebral palsy (CP). Indeed, because of its subjective nature, the complexity of the underlying mechanism of fatigue, and its variable impact on function, children with perinatal stroke may describe fatigue in different ways.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Factors associated with fatigue in children with perinatal stroke

Stubberud

2019

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

Fatigue in Child Chronic Health Conditions: A Systematic Review of Assessment Instruments

Cited by 60 publications

References 130 publications

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Cognitive fatigue in relation to depressive symptoms after treatment for childhood cancer

Factors associated with fatigue in children with perinatal stroke

Contact Info

Product

Resources

About