Fatigue heralding multiple sclerosis

Berger, Joseph R.; Pocoski, Jennifer; Preblick, Ronald; Boklage, Susan

doi:10.1177/1352458513477924

Cited by 60 publications

(42 citation statements)

References 19 publications

(25 reference statements)

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“…10 Perceived F atigue is the most debilitating symptom of multiple sclerosis (MS). 1 It interferes with daily function, affects workload, and hampers interpersonal relationships, often leading to reduced quality of life. 2 Fatigue related to MS is multidimensional, consisting of this study was to explore the relationship between perceived fatigue, as measured using the NFI-MS, and performance fatigability in people with MS.…”

mentioning

confidence: 99%

Relationship Between Fatigability and Perceived Fatigue Measured Using the Neurological Fatigue Index in People with Multiple Sclerosis

Aldughmi¹,

Bruce²,

Siengsukon³

2017

International Journal of MS Care

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Background: Understanding the relationship between perceived fatigue and performance fatigability could lead to more effective interventions to manage multiple sclerosis (MS)-related fatigue. However, the relationship between self-perceived fatigue measured using the Neurological Fatigue Index (NFI-MS) and performance fatigability in people with MS is unknown. We sought to explore the relationship between the NFI-MS and performance fatigability in people with MS.

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mentioning

confidence: 99%

Relationship Between Fatigability and Perceived Fatigue Measured Using the Neurological Fatigue Index in People with Multiple Sclerosis

Aldughmi¹,

Bruce²,

Siengsukon³

2017

International Journal of MS Care

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“…As early as 1949, fatigue was recognized as an important symptom of MS (49). Fatigue is often one of the first symptoms to occur, and can be present years before the diagnosis of MS (9, 52). Although fatigue in MS has been studied for more than fifty years, mechanisms underlying fatigue are poorly understood.…”

Section: Fatigue In Neurological Disordersmentioning

confidence: 99%

Disease-Induced Skeletal Muscle Atrophy and Fatigue

Powers

Lynch

Murphy

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

154

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Numerous health problems including acute critical illness, cancer, diseases associated with chronic inflammation, and neurological disorders often result in skeletal muscle weakness and fatigue. Disease-related muscle atrophy and fatigue is an important clinical problem because acquired skeletal muscle weakness can increase the duration of hospitalization, result in exercise limitation, and contribute to a poor quality of life. Importantly, skeletal muscle atrophy is also associated with increased morbidity and mortality of patients. Therefore, improving our understanding of the mechanism(s) responsible for skeletal muscle weakness and fatigue in patients is a required first step to develop clinical protocols to prevent these skeletal muscle problems. This review will highlight the consequences and potential mechanisms responsible for skeletal muscle atrophy and fatigue in patients suffering from acute critical illness, cancer, chronic inflammatory diseases, and neurological disorders.

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“…At least one out of four MS patients views fatigue as the most burdensome symptom of their illness, and the majority of MS patients (more than 80%) suffer from fatigue [4]. Fatigue may occur at any stage of the disease and can even precede MS onset by several years [5]. Fatigue is a major reason for early retirement, reduced employment, and poor quality of life in people with MS [6–8].…”

Section: Introductionmentioning

confidence: 99%

The Berlin Treatment Algorithm: recommendations for tailored innovative therapeutic strategies for multiple sclerosis-related fatigue

et al. 2016

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More than 80% of multiple sclerosis (MS) patients suffer from fatigue. Despite this, there are few therapeutic options and evidence-based pharmacological treatments are lacking. The associated societal burden is substantial (MS fatigue is a major reason for part-time employment or early retirement), and at least one out of four MS patients view fatigue as the most burdensome symptom of their disease. The mechanisms underlying MS-related fatigue are poorly understood, and objective criteria for distinguishing and evaluating levels of fatigue and tiredness have not yet been developed. A further complication is that both symptoms may also be unspecific indicators of many other diseases (including depression, sleep disorders, anemia, renal failure, liver diseases, chronic obstructive pulmonary disease, drug side effects, recent MS relapses, infections, nocturia, cancer, thyroid hypofunction, lack of physical exercise). This paper reviews current treatment options of MS-related fatigue in order to establish an individualized therapeutic strategy that factors in existing comorbid disorders. To ensure that such a strategy can also be easily and widely implemented, a comprehensive approach is needed, which ideally takes into account all other possible causes and which is moreover cost efficient. Using a diagnostic interview, depressive disorders, sleep disorders and side effects of the medication should be identified and addressed. All MS patients suffering from fatigue should fill out the Modified Fatigue Impact Scale, Epworth Sleepiness Scale, the Beck Depression Inventory (or a similar depression scale), and the Pittsburgh Sleep Quality Index (or the Insomnia Severity Index). In some patients, polygraphic or polysomnographic investigations should be performed. The treatment of underlying sleep disorders, drug therapy with alfacalcidol or fampridine, exercise therapy, and cognitive behavioral therapy-based interventions may be effective against MS-related fatigue. The objectives of this article are to identify the reasons for fatigue in patients suffering from multiple sclerosis and to introduce individually tailored treatment approaches. Moreover, this paper focuses on current knowledge about MS-related fatigue in relation to brain atrophy and lesions, cognition, disease course, and other findings in an attempt to identify future research directions.

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Fatigue heralding multiple sclerosis

Abstract: This study demonstrates that fatigue may herald MS, often by years. A careful history for transient neurological symptoms and a physical examination is warranted in any patient presenting with fatigue.

Cited by 60 publications

References 19 publications

Relationship Between Fatigability and Perceived Fatigue Measured Using the Neurological Fatigue Index in People with Multiple Sclerosis

Relationship Between Fatigability and Perceived Fatigue Measured Using the Neurological Fatigue Index in People with Multiple Sclerosis

Disease-Induced Skeletal Muscle Atrophy and Fatigue

The Berlin Treatment Algorithm: recommendations for tailored innovative therapeutic strategies for multiple sclerosis-related fatigue

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