Corrosion fatigue behaviour and microstructural characterisation of G20Mn5QT cast steel are investigated in simulated seawater. Fractography is performed by using scanning electron microscopy (SEM). The macroscale fracture surface and microstructure of the failed specimen are acquired including the crack initiation, crack propagation, and pitting evolution. The maximum cyclic stress (S) versus number of cycles to failure (N) curves is derived by three‐parameter fatigue curve method. Fatigue life is predominantly controlled by the corrosion pitting‐induced crack initiation when tested in simulated seawater at lower stress levels. As the maximum cyclic stress is less than 185 MPa, the chloride ion erosion is the main influence factor, which affects the fatigue failure of the G20Mn5QT cast steel in simulated seawater.