Fatigue behavior of As-built selective laser melted titanium scaffolds with sheet-based gyroid microarchitecture for bone tissue engineering

Kelly, Cambre; Francovich, Jaedyn; Julmi, Stefan; Safranski, David L.; Guldberg, Robert E.; Maier, Hans Jürgen; Gall, Ken

doi:10.1016/j.actbio.2019.05.046

Cited by 171 publications

(73 citation statements)

References 34 publications

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“…Figure 4D shows the results from cyclic tensile testing for the BC–PVA–PAMPS hydrogel, its components in different combinations, as well as porous titanium for comparison. [ 86 ] The BC–PVA–PAMPS hydrogel exhibited a remarkably high fatigue strength of 8.62 MPa at 10 5 cycles, which is comparable to 85% porous 3D‐printed titanium. [ 86 ] Addition of PAMPS to BC decreased its resistance to fatigue due to the brittle nature of PAMPS.…”

Section: Resultsmentioning

confidence: 99%

“…[ 86 ] The BC–PVA–PAMPS hydrogel exhibited a remarkably high fatigue strength of 8.62 MPa at 10 5 cycles, which is comparable to 85% porous 3D‐printed titanium. [ 86 ] Addition of PAMPS to BC decreased its resistance to fatigue due to the brittle nature of PAMPS. [ 91 ] The addition of PVA to BC increased fatigue resistance due to the toughness of PVA; [ 56–58 ] all four BC–PVA samples were free of damage at 10 5 cycles.…”

Section: Resultsmentioning

confidence: 99%

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A Synthetic Hydrogel Composite with the Mechanical Behavior and Durability of Cartilage

Yang

Zhao

Koshut

et al. 2020

Adv Funct Materials

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191

178

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This article reports the first hydrogel with the strength and modulus of cartilage in both tension and compression, and the first to exhibit cartilage‐equivalent tensile fatigue strength at 100 000 cycles. These properties are achieved by infiltrating a bacterial cellulose (BC) nanofiber network with a poly(vinyl alcohol) (PVA)–poly(2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid sodium salt) (PAMPS) double network hydrogel. The BC provides tensile strength in a manner analogous to collagen in cartilage, while the PAMPS provides a fixed negative charge and osmotic restoring force similar to the role of aggrecan in cartilage. The hydrogel has the same aggregate modulus and permeability as cartilage, resulting in the same time‐dependent deformation under confined compression. The hydrogel is not cytotoxic, has a coefficient of friction 45% lower than cartilage, and is 4.4 times more wear‐resistant than a PVA hydrogel. The properties of this hydrogel make it an excellent candidate material for replacement of damaged cartilage.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Synthetic Hydrogel Composite with the Mechanical Behavior and Durability of Cartilage

Yang

Zhao

Koshut

et al. 2020

Adv Funct Materials

Self Cite

191

178

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show abstract

“…While the influence of on the mechanical performance under quasi-static mechanical properties is the primary consideration for this study, its influence on fatigue behaviour is also critical for the proper functioning of metallic scaffolds [214][215][216][217]. Even though much of what is discussed regarding the influence of is valid regardless of the nature of loading, fatigue performance stills remain a concern for AM biomaterials [218]. When scaffolds feature geometrical changes that give rise to high stress concentrations, fatigue failures generally tend to initiate from these locations [219][220][221].…”

Section: Discussionmentioning

confidence: 99%

Mechanical performance of highly permeable laser melted Ti6Al4V bone scaffolds

Arjunan

Demetriou

Baroutaji

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

116

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Critically engineered stiffness and strength of a scaffold are crucial for managing maladapted stress concentration and reducing stress shielding. At the same time, suitable porosity and permeability are key to facilitate biological activities associated with bone growth and nutrient delivery. A systematic balance of all these parameters are required for the development of an effective bone scaffold. Traditionally, the approach has been to study each of these parameters in isolation without considering their interdependence to achieve specific properties at a certain porosity. The purpose of this study is to undertake a holistic investigation considering the stiffness, strength, permeability, and stress concentration of six scaffold architectures featuring a 68.46-90.98% porosity. With an initial target of a tibial host segment, the permeability was characterised using Computational Fluid Dynamics (CFD) in conjunction with Darcy's law. Following this, Ashby's criterion, experimental tests, and Finite Element Method (FEM) were employed to study the mechanical behaviour and their interdependencies under uniaxial compression. The FE model was validated and further extended to study the influence of stress concentration on both the stiffness and strength of the scaffolds. The results showed that the pore shape can influence permeability, stiffness, strength, and the stress concentration factor of Ti6Al4V bone scaffolds. Furthermore, the numerical results demonstrate the effect to which structural performance of highly porous scaffolds deviate, as a result of the Selective Laser Melting (SLM) process. In addition, the study demonstrates that stiffness and strength of bone scaffold at a targeted porosity is linked to the pore shape and the associated stress concentration allowing to exploit the design freedom associated with SLM.

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“…In previous studies [12,14,15,20], the Gibson-Ashby model has been extensively used to predict the relationship between the porosity of a porous structure and its elastic modulus and yield strength. The relationship can be expressed by the following formula:…”

Section: Gibson-ashby Modelmentioning

confidence: 99%

“…Furthermore, the titanium alloy Ti-6Al-4V has high specific strength, low density, high fracture toughness, and excellent corrosion resistance [11], which adds to its wide applicability in the manufacturing of porous structures. In recent years, there have been many studies [12][13][14][15] about porous Ti64 structures; most of the works are about the effects of topological morphology (different porosity, different pore size, or different pore unit) on the mechanical properties, permeability, and biological properties of porous structure. However, research on the effects of heat treatment processing on the microstructural and mechanical properties of additively manufactured porous Ti64 structure is still limited.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Post Heat Treatment on the Microstructural and Mechanical Properties of an Additive-Manufactured Porous Titanium Alloy

Hua

et al. 2020

Materials

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In this work, Ti-6Al-4V (Ti64) porous structures were prepared by selective laser melting (SLM), and the effects of post heat treatment on its microstructural and mechanical properties were investigated. The results showed that as SLM samples were mainly composed of needle-like α′ martensite. Heat treatment at 750 °C caused α′ phase to decompose, forming a lamellar α+β mixed microstructure. As the heat treatment temperature increased to 950 °C, the width of lamellar α phase gradually increased to 3.1 μm. Heat treatment also reduced the compressive strength of the samples; however, it significantly improved the ductility of the porous Ti64. Moreover, heat treatment improved the energy absorption efficiency of the porous Ti64. The samples heat-treated at 750 °C had the highest energy absorption of 233.6 ± 1.5 MJ/m3 at ε = 50%.

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Fatigue behavior of As-built selective laser melted titanium scaffolds with sheet-based gyroid microarchitecture for bone tissue engineering

Cited by 171 publications

References 34 publications

A Synthetic Hydrogel Composite with the Mechanical Behavior and Durability of Cartilage

A Synthetic Hydrogel Composite with the Mechanical Behavior and Durability of Cartilage

Mechanical performance of highly permeable laser melted Ti6Al4V bone scaffolds

The Effects of Post Heat Treatment on the Microstructural and Mechanical Properties of an Additive-Manufactured Porous Titanium Alloy

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