Fatigue and Proinflammatory Cytokine Activity in Breast Cancer Survivors

Bower, Julienne E.; Ganz, Patricia A.; Aziz, Najib; Fahey, John L.

doi:10.1097/00006842-200207000-00010

Cited by 481 publications

(387 citation statements)

References 44 publications

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“…However, in the present study, items of the CES-D and the FAS loaded on two different factors (data not shown), as in the development phase of the FAS [19]. This is in line with a study on BC survivors [5], in which fatigue, instead of being secondary to depression, cooccurred with depression as part of a coordinated response elicited by cytokine actions of the central nervous system.…”

Section: Discussionsupporting

confidence: 90%

Personality and fatigue in patients with benign or malignant breast disease

Michielsen

Steeg

Roukema

et al. 2007

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Goals of work The aim of the study was to examine the role of five general personality traits in fatigue in a group of patients with breast cancer (BC) and a group with benign breast problems (BBP). Materials and methods Of the 304 participating women, 127 patients had BC and 177 BBP. A fatigue scale was completed before diagnosis and 1, 3, and 6 months after diagnosis (benign patients) or surgical treatment (BC patients). A personality questionnaire (NEO-FFI) and a depression scale (CES-D) were completed before diagnosis. Main results The BC group was less tired before diagnosis, more tired 1 month after diagnosis, and equally tired 3 and 6 months after diagnosis. In the total group, women were more tired over time when they were more neurotic, less agreeable, or more introverted. After controlling for depressive symptoms, demographics, and medical factors, baseline depressive symptoms (β=0.29, p<0.05), neuroticism (β=0.29, p<0.05), and extraversion (β=−0.25, p< 0.05) predicted fatigue 6 months later. After also including baseline fatigue, only neuroticism (β=0.22, p<0.05) and baseline fatigue (β=0.79, p<0.001) predicted fatigue.Conclusions Personality is more strongly related to fatigue than demographics, the diagnosis cancer, receiving cancer treatment, and baseline depressive symptoms and fatigue. When replicated, screening and treating women who are at risk to experience high levels of fatigue is recommended.

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Section: Discussionsupporting

confidence: 90%

Personality and fatigue in patients with benign or malignant breast disease

Michielsen

Steeg

Roukema

et al. 2007

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“…We have documented elevations in soluble markers of inflammation in two separate cohorts of breast cancer survivors that are suggestive of a chronic inflammatory state (Bower et al, 2002;Collado-Hidalgo et al, 2006). Our recent work extends these findings to the acute treatment setting and suggests that activation of proinflammatory cytokines may also play a role in fatigue onset during radiation therapy among both breast and prostate cancer patients .…”

Section: Conclusion and Recommendations For Future Researchsupporting

confidence: 59%

“…There are two potential pathways for impaired control of proinflammatory cytokines by the HPA axis: decreased glucocorticoid production, and decreased response of the glucocorticoid receptor to hormone ligation (Raison and Miller, 2003). In an initial study, we found that fatigued breast cancer survivors had lower levels of morning serum cortisol than nonfatigued controls, supporting decreased production as a potential mechanism for enhanced inflammation (Bower et al, 2002). Because a single measure of cortisol provides little information about this system, we have also examined two dynamic measures of HPA axis activity, diurnal cortisol secretion and cortisol response to challenge, as well as glucocorticoid receptor sensitivity, in relation to cancer-related fatigue.…”

Section: Mechanisms For Persistent Inflammation and Fatiguementioning

confidence: 83%

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Cancer-related fatigue: Links with inflammation in cancer patients and survivors

Bower

2007

Brain, Behavior, and Immunity

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219

153

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Fatigue is one of the most common and distressing side effects of cancer and its treatment and may persist long after successful treatment completion. Emerging evidence suggests that inflammatory processes may be involved in cancer-related fatigue both during and after treatment. In this review, we consider the evidence for an association between inflammation and fatigue in cancer patients and survivors. Further, we identify potential mechanisms for persistent inflammation, focusing on the HPA axis. Risk factors and treatments for cancer-related fatigue are also discussed.

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“…In the past few years, IL-1ra has attracted considerable clinical attention because its serum levels are elevated in pathologies as diverse as sepsis, cancer, metabolic diseases and auto-immune diseases [24] whereas the plasma IL-1ra/IL-1 ratio in a healthy population is close to 1 and exhibits minimal variation [25]. A significant increase of plasma IL-1ra is associated with post-treatment fatigue in breast cancer survivors [26].…”

Section: Il-1 Family: Generalitiesmentioning

confidence: 99%

IL‐1 family in breast cancer: Potential interplay with leptin and other adipocytokines

2008

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Edited by Masayuki MiyasakaKeywords: IL-1 Leptin Adipocytokine Breast cancer Obesity a b s t r a c t Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.

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Fatigue and Proinflammatory Cytokine Activity in Breast Cancer Survivors

Cited by 481 publications

References 44 publications

Personality and fatigue in patients with benign or malignant breast disease

Personality and fatigue in patients with benign or malignant breast disease

Cancer-related fatigue: Links with inflammation in cancer patients and survivors

IL‐1 family in breast cancer: Potential interplay with leptin and other adipocytokines

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