Fatigue and basal ganglia

Chaudhuri, Abhijit; Behan, Peter O.

doi:10.1016/s0022-510x(00)00411-1

Cited by 546 publications

(597 citation statements)

References 42 publications

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“…Peripheral or motor fatigue is due to fatigue in either the muscle itself or due to brain control over the muscle. 16 Lee et al categorized the multi-dimensional fatigue experience of hemodialysis (HD) patients in Taiwan into three inextricably linked domains -physical, affective and cognitive. 17 These theoretical frameworks underscore the multi-dimensional aspects of fatigue and suggest that physiological, psychological and socio-demographic factors contribute to fatigue.…”

Section: Definition Of Fatiguementioning

confidence: 99%

Fatigue in Patients Receiving Maintenance Dialysis: A Review of Definitions, Measures, and Contributing Factors

Jhamb

Weisbord

Steel

et al. 2008

American Journal of Kidney Diseases

277

300

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Fatigue is a debilitating symptom or side effect experienced by many patients on long-term dialysis. Fatigue has a considerable effect on patients' health-related quality of life and is viewed as being more important than survival by some patients. There are many challenges renal providers face when attempting to reduce fatigue in dialysis patients. The lack of a reliable, valid, and sensitive fatigue scale complicates the accurate identification of this symptom. Symptoms of daytime sleepiness and depression overlap with fatigue, making it difficult to target specific therapies. Moreover, many chronic health conditions common in the long-term dialysis population may lead to the development of fatigue and contribute to the day-to-day and diurnal variation of fatigue in patients. Key to improving the assessment and treatment of fatigue is improving our understanding of potential mediators, as well as potential therapies. Cytokines have emerged as an important mediator of fatigue and have been studied extensively in cancer related fatigue. In addition, although erythropoietin stimulating agents (ESA) have been shown to mitigate fatigue, the recent controversy regarding ESA dosing in chronic kidney disease (CKD) suggests that ESA therapy may not serve as the sole therapy to improve fatigue in this population. In conclusion, fatigue is an important and often underrecognized symptom in the dialysis population. Possible interventions for minimizing fatigue in patients on long-term dialysis should be aimed at improving health care provider awareness, developing improved methods of measurement, better understanding of the pathogenesis, as well as management of known contributing factors.

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Section: Definition Of Fatiguementioning

confidence: 99%

Fatigue in Patients Receiving Maintenance Dialysis: A Review of Definitions, Measures, and Contributing Factors

Jhamb

Weisbord

Steel

et al. 2008

American Journal of Kidney Diseases

277

300

View full text Add to dashboard Cite

show abstract

“…Muscle fatigue is considered to be both a "negative" consequence of physical activity and a "positive" safety mechanism, to prevent injury or death during exercise (23). Centrally conditioned fatigue is more complex, and entails both chemical and hormonal factors in nerve cells and their synapses, e.g., as changes in neurotransmitter levels in various brain structures (24), but also psychological factors such as endurance, motivation (25,26), mood, and expectation of task difficulty (23,27). Fatigue which cannot be relieved by rest or sleep is a frequent sign of disease.…”

Section: Definitions Of Fatiguementioning

confidence: 99%

Fatigue in older adults: an early indicator of the aging process?

2010

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“…Thus, while the item may be relevant to fatigue, it may not behave in harmony with the content of the other FSS items. Furthermore, although perceived lack of motivation may not be caused by fatigue (as implied by FSS item 1), central motivational processes may still be an important contributor to the experience of fatigue (2).…”

Section: Several Multidimensional Instruments Have Been Developed To mentioning

confidence: 99%

“…For example, in contrast to using cross-validated generic instruments, results do not allow for direct comparisons across patient groups or with healthy control populations. This is potentially problematic because of the largely unknown cause(s) of fatigue and the need to identify effective therapy, which both well may be nondisease specific (2,3). However, the relative merit of the Parkinson Fatigue Scale and more generic tools such as the FACIT-F and FSS will need to be assessed empirically.…”

Section: Several Multidimensional Instruments Have Been Developed To mentioning

confidence: 99%

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Measuring Fatigue in Parkinson's Disease: A Psychometric Study of Two Brief Generic Fatigue Questionnaires

Hagell

Höglund

Reimer

et al. 2006

Journal of Pain and Symptom Management

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This study evaluated and compared the measurement properties of the 13-item FACITFatigue Scale (FACIT-F) and the 9-item Fatigue Severity Scale (FSS) in 118 consecutive Parkinson's disease (PD) patients, using traditional and Rasch measurement methodologies.Both questionnaires exhibited excellent data quality and reliability (coefficient alpha ≥0.9), acceptable rating scale functionality, and discriminated between fatigued and non-fatigued patients. Factor and Rasch analyses provided general support for unidimensionality of both the FACIT-F and FSS, although they do not appear to measure identical aspects of fatigue.No signs of differential item functioning (DIF) were found for the FACIT-F whereas potential age DIF was detected for 2 FSS items. These results support the measurement validity of both questionnaires in PD, although the FACIT-F displayed better measurement precision and modest psychometric advantages over the FSS. Availability of psychometrically sound fatigue measures that are applicable across disorders provides a sound basis for advancing the understanding of this common and distressing complaint. Fatigue can be defined as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion (1) and is a common complaint in a range of medical conditions, including many neurological disorders (1-3). In a clinical context, fatigue is considered to be a multidimensional concept with physical, emotional, cognitive, and social aspects. This can pose a challenge to measurement. In Parkinson's disease (PD), fatigue has been reported in 40-65% of patients and although many consider it to be one of their most disabling symptoms, it often remains undetected in clinical practice (4)(5)(6)(7)(8). Its cause remains unclear. For example, while some reports suggest an association between fatigue and the underlying parkinsonism (5, 9), others do not (10, 11).One reason for such mixed results may relate to how fatigue has been assessed. Studies have tended to use fatigue scales from generic health status questionnaires or approaches not validated in [10][11][12]. Although generic health status questionnaires have been validated broadly, their subscales are brief and often lack sufficient detail for accurately measuring individuals. For example, the Energy subscale of the Nottingham Health Profile (NHP-EN) (13) has been found to be only a coarse measure of fatigue (14). Other employed instruments have been validated in other patient groups but remain untested in terms of their measurement properties in PD. This is a limitation because traditional psychometric properties are sample dependent. Thus their performance in specific applications is important to consider in the context of accumulated experience with an instrument (15). There is thus a need for fatigue measures with documented reliability and validity in specific patient populations, such as PD, that also allow for comparisons with other patient groups and healthy control populations (3).We therefore sought to identify and validate an availa...

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Fatigue and basal ganglia

Cited by 546 publications

References 42 publications

Fatigue in Patients Receiving Maintenance Dialysis: A Review of Definitions, Measures, and Contributing Factors

Fatigue in Patients Receiving Maintenance Dialysis: A Review of Definitions, Measures, and Contributing Factors

Fatigue in older adults: an early indicator of the aging process?

Measuring Fatigue in Parkinson's Disease: A Psychometric Study of Two Brief Generic Fatigue Questionnaires

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