Fatigue Affects Health Status and Predicts Mortality Among Subjects with COPD: Report from the Population-Based OLIN COPD Study

Abstract

Fatigue and decreased health status were closely related among subjects with and without COPD. Not only physical health status, but also fatigue and mental health predicted mortality among subjects with COPD. Fatigue assessed by FACIT-F, can be a useful instrument of prognostic value in the care of subjects with COPD.

Physical activity and fatigue in chronic obstructive pulmonary disease – A population based study

“…Low physical activity is a strong predictor of mortality in COPD [5], and according to a recent report from the Copenhagen City Heart study also changes in physical activity towards decreased physical activity is associated to mortality among subjects with COPD [17]. We have previously shown that fatigue, as well as reduced physical health score, is associated to mortality among subjects with COPD [55]. Taken together, these findings imply that it is important to encourage physical activity among subjects with COPD, and when initiating rehabilitation, addressing fatigue could be an important component of rehabilitation efforts.…”

Differences in Symptom Burden Among Patients With Moderate, Severe, or Very Severe Chronic Obstructive Pulmonary Disease

“…In addition, findings from a recent study suggest that fatigue has deleterious effects on patient's mental health and was associated with increased mortality in patients with COPD. 26 Taken together, these findings suggest that clinicians need to evaluate for fatigue on a routine basis.…”

Increased Incidence of Fatigue in Patients with Primary Immunodeficiency Disorders: Prevalence and Associations Within the US Immunodeficiency Network Registry

“…Additionally, fatigue was associated with worse prognosis in patients with heart failure [12], had negative impact on health status, function, and mortality in an elderly population [13], and predicted mortality in chronic obstructive lung disease [14]. In another study, low levels of fatigue independently predicted longer recurrence-free and overall survival from breast cancer, when controlling for biological factors [15].…”