Fate of TiO2 nanoparticles entering sewage treatment plants and bioaccumulation in fish in the receiving streams

Xiao-mei, Shi; Li, Zaixing; Chen, Wei; Qiang, Liwen; Xia, Junchao; Chen, Meng; Zhu, Lingyan; Alvarez, Pedro J. J.

doi:10.1016/j.impact.2016.09.002

Cited by 83 publications

(36 citation statements)

References 62 publications

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“…A similar effect has also been found in another freshwater species (goldfish) exposed to TiO 2 ‐NP. Additionally, if TiO 2 ‐NP can accumulate in muscles and brain, as shown here, they might as well accumulate in fish hematopoietic and lymphoid organs like the spleen and kidney, thus affecting WBC production in these organs. This effect on immune system is common after metal contamination causing destruction, sensitization, and alteration of cellular functions, such as the phagocytic activity of macrophages and neutrophils, or indirectly through the induction or inhibition of cell proliferation or cellular precursor's formation …”

Section: Discussionsupporting

confidence: 84%

“…Although most of the TiO 2 ‐NP have quickly deposited on the aquariums' bottom due to their instability in water, some amount remained in suspension on the water column as reported in a previous study. Low concentrations of TiO 2 ‐NP suspended in the water column in anthropic polluted environment (receiving river streams) were also reported to cause TiO 2 ‐NP accumulation in liver, brain, and muscle of crucian carp. In the environment, P. lineatus is also exposed to sediment when foraging for food, so this species may absorb TiO 2 ‐NP through its gut in addition to its gills.…”

Section: Discussionmentioning

confidence: 64%

“…In aqueous solutions, TiO 2 ‐NP tend to agglomerate/aggregate or interact with suspended organic matter, and then deposit on the sediment . However, some TiO 2 ‐NP remain suspended in the water column (52‐86 μgL −1 ), mostly near sewages . In both cases, TiO 2 ‐NP discarded into aquatic systems will likely be absorbed by the resident biota and negatively affect them.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, exposure to TiO 2 ‐NP may cause damages to the liver tissue, such as the presence of disordered cells, apoptotic nuclei, and foci with lipid accumulation . Even in low concentrations, TiO 2 ‐NP can also accumulate in other fish organs such as muscle and brain, thus affecting the metabolism of neurotransmitters.…”

Section: Introductionmentioning

confidence: 99%

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Overview of the toxic effects of titanium dioxide nanoparticles in blood, liver, muscles, and brain of a Neotropical detritivorous fish

Carmo

Siqueira

Azevedo

et al. 2019

Environmental Toxicology

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The toxicity of titanium dioxide nanoparticles (TiO 2 -NP) in the blood, liver, muscle, and brain of a Neotropical detritivorous fish, Prochilodus lineatus, was tested. Juvenile fish were exposed to 0, 1, 5, 10, and 50 mg L −1 of TiO 2 -NP for 48 hours (acute exposure) or 14 days (subchronic exposure) to evaluate changes in hematology, red blood cell (RBC) genotoxicity/mutagenicity, liver function (reactive oxygen species (ROS) production, antioxidant responses, detoxification, and histopathology), acetylcholinesterase (AChE) activity in muscles and brain, and Ti bioaccumulation. TiO 2 -NP did not cause genetic damage to RBC, but acutely decreased white blood cells (WBC) and increased monocytes. Subchronically, RBC decreased, mean cell volume and hemoglobin increased, and WBC and lymphocytes decreased. Therefore, NP has the potential to affect immune system and increase energy expenditure, reducing the fish's ability to avoid predator and to resist pathogens. In the liver, acute exposure decreased ROS and increased glutathione (GSH) content, while subchronic exposure decreased superoxide dismutase activity and increased glutathione-S-transferase (GST) activity and GSH content. GSH and GST seem to play an essential role in metabolizing NP and ROS, likely increasing hepatocytes' metabolic rate, which may be the cause of observed cell hypertrophy, disarrangement of hepatic cords and degenerative morphological alterations. Although most studies indicate that the kidney is responsible for metabolizing and/or eliminating TiO 2 -NP, this study shows that the liver also has a main role in these processes. Nevertheless, Ti still accumulated in the liver, muscle, and brain and decreased muscular AChE activity after acute exposure, showing neurotoxic potential.More studies are needed to better understand the biochemical pathways TiO 2 -NP are metabolized and how its bioaccumulation may affect fish homeostasis and survival in the environment. K E Y W O R D S bioaccumulation, glutathione-S-transferase neurotoxicity, immune system, reactive oxygen species

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Overview of the toxic effects of titanium dioxide nanoparticles in blood, liver, muscles, and brain of a Neotropical detritivorous fish

Carmo

Siqueira

Azevedo

et al. 2019

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…The release of these compounds from cosmetics and personal care products applied on skin into the environment can occur due to immersion or abrasion with sand [77]. TiO 2 is also released into aquatic environments from sources other than sunscreens (anthropogenic input due to its use as a food ingredient, textile washing, leaching from facade coatings); wastewater treatment plants (WWTPs) remove the majority of TiO 2 present in the influent sewage, but a small amount is released into natural water bodies [30,77]. TiO 2 residues…”

Section: Inorganic Filtersmentioning

confidence: 99%

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

2017

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Cosmetic and personal care products are used in huge quantities throughout the world; as a result of their regular use, they are continuously released into the environment in very large amounts. Many of these products are biologically active and are characterized by persistence and bioaccumulation potential, posing a threat to ecosystem and human health. On the basis of the most recent scientific literature available on this subject, this paper provides an overview of some cosmetic ingredients that are considered environmental emerging pollutants of particular concern such as UV filters, some preservatives (parabens, triclosan), and microplastics.

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Continued Efforts on Nanomaterial‐Environmental Health and Safety Is Critical to Maintain Sustainable Growth of Nanoindustry

Liu

Xia

2020

Small

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Nanotechnology is enjoying an impressive growth and the global nanotechnology industry is expected to exceed US$ 125 billion by 2024. Based on these successes, there are notions that enough is known and efforts on engineered nanomaterial environmental health and safety (nano‐EHS) research should be put on the back burner. However, there are recent events showing that it is not the case. The US Food and Drug Administration found ferumoxytol (carbohydrate‐coated superparamagnetic iron oxide nanoparticle) for anemia treatment could induce lethal anaphylactic reactions. The European Union will categorize TiO2 as a category 2 carcinogen due to its inhalation hazard and France banned use of TiO2 (E171) in food from January 1, 2020 because of its carcinogenic potential. Although nanoindustry is seemingly in a healthy state, growth could be hindered for the lack of certainty and more nano‐EHS research is needed for the sustainable growth of nanoindustry. Herein, the current knowledge gaps and the way forward are elaborated.

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Fate of TiO2 nanoparticles entering sewage treatment plants and bioaccumulation in fish in the receiving streams

Cited by 83 publications

References 62 publications

Overview of the toxic effects of titanium dioxide nanoparticles in blood, liver, muscles, and brain of a Neotropical detritivorous fish

Overview of the toxic effects of titanium dioxide nanoparticles in blood, liver, muscles, and brain of a Neotropical detritivorous fish

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

Continued Efforts on Nanomaterial‐Environmental Health and Safety Is Critical to Maintain Sustainable Growth of Nanoindustry

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