Fate of Procaine in the Human Body After Subarachnoid Injection

Studies With a Radioactive Spinal Anaesthetic

“…In the tissues, however, procaine and probably DBP is broken down into a number of products (Burgen et al, 1948;Goldberg et al, 1943) Method Cats anaesthetized with pentobarbitone received various doses of DBP, HC1 by lumbar puncture. The needle was left in situ with stilette in position, but at fixed time intervals the stilette was withdrawn, and, after permitting a few drops of C.S.F.…”

Quantitative Studies of Procaine Metabolism in the Cat

“…These results were confirmed by Dunlop (1935) in experiments on dogs, in which procaine and p-aminobenzoic acid blood levels were determined by a diazotization method, using /-naphthol as coupling reagent; after hepatectomy he still found some destruction of procaine which was attributed to an action by tissues other than the liver, though blood itself appeared to be inactive. Recently, however, Goldberg, Koster, and Warshaw (1943), Kisch, Koster, andHazard andRavasse (1945) have adapted the Bratton and Marshall (1939) method for sulphonamides to the determination of procaine and p-aminobenzoic acid in blood and tissue fluids. They have shown that the plasma and serum of many species of animals, including man (in whom the effect is most powerful of all), can hydrolyse procaine to p-aminobenzoic acid and diethylaminoethanol.…”