Fate of methyl methacrylate in rats

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 6 (FGE.06): Straight-and branched-chain aliphatic unsatured primary alcohols, aldehydes, carbox

“…Methyl methacrylate given to rats by gavage was also eliminated mainly as CO 2 (Bratt & Hathway, 1977).…”

Depressive Effects of Acrylic Cement Components on Bone Metabolism:Isotope Release and Phosphatase Production Studied in Vitro

“…The monomer is metabolised to non-toxic chemical components in the body (Bratt & Hathway 1977). The effect of circulating monomer is thus of minor interest, while locally the highest concentration of unmetabolised monomer must be found, giving the strongest toxic effect at the cement bone interface.…”

Joint FAO/WHO Expert Committee on Food Additives (JECFA)

“…Regardless of the route of administration, the dose or the place of the radiolabel, 76-88% of the radiolabel was eliminated as exhaled 14 CO2, approximately 65% of which within the first 2 h after administration. Only minor amounts of radiolabel were eliminated in the urine (4.7-7.2%) and faeces (1.7-3.0%) (Bratt & Hathway, 1977).…”

“…In addition, liver slices were preincubated with arsenite, a known inhibitor of the citric acid cycle, at 1 mmol/l for 2 h and with malonate, another inhibitor of the citric acid cycle, at 10 mmol/l for 1 h. Malonate exerted no inhibition on the metabolic transformation of methyl 2-methyl-2-propenoate, whereas arsenite inhibited the metabolic transformation. It is not exactly clear how these inhibitors act in the citric acid cycle, but, according to the authors, this indicates that methyl 2-methyl-2-propenoate enters the citric acid cycle as pyruvate (Pantucek, 1969 Figure 2) (Bratt & Hathway, 1977). According to Pantucek (1969), methyl 2-methyl-2-propenoate enters the citric acid cycle via the formation of pyruvate rather than via the formation of succinyl coenzyme A (CoA).…”