Fate of manganese associated with the inhalation of welding fumes: Potential neurological effects

Antonini, James M.; Santamaria, Annette B.; Jenkins, N; Albini, Elisa; Lucchini, Roberto

doi:10.1016/j.neuro.2005.09.001

Cited by 106 publications

(110 citation statements)

References 38 publications

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“…Some researchers have reported adverse health effects from smelting as well as welding activities. Others have stated they are unsure if welding activities may cause neurologic damage [10], while some have definitively stated it cannot occur [6]. Our findings fit with others already noted in the scientific literature attesting to the release of manganese from welding activities causing neurologic damage, as well as a variety of other symptoms.…”

Section: Short-term High Exposures (> 1 Mg/msupporting

confidence: 88%

“…The questionnaire collected smoking habit data and found that out of the 505 welders, 289 were smokers such a relationship. Others call for more research [10]. Our belief, especially given the findings reported here, is that there is indeed a significant effect on the neurologic system, as well as the development of other symptoms, following exposure to manganese through welding activities.…”

Section: Introductionsupporting

confidence: 45%

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Health effects of manganese exposures for welders in Qingdao City, China

Zhang

Wang

et al. 2016

Int J Occup Med Environ Health

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Objectives: To document if manganese from welding causes health effects including neurological symptoms associated with manganese exposure. Material and Methods: An anonymous questionnaire survey for a total of 505 welders at 3 welding facilities in Qingdao City, China was administered and analyzed. Results: Numerous symptoms were reported by the welders including difficulty with eyes for 43% of them, sore throat for 30% of them, and tremors were reported by over 18% of them. Tremors were associated with longer periods of work as a welder and correlated with the relative cleanliness at the 3 different facilities. Tremors did not correlate with smoking. Conclusions: Manganese-exposed welders reported a variety of symptoms related to work and showed neurological disturbances that correlated with amount of exposure. Int J Occup Med Environ Health 2017;30(2):241-247

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Section: Short-term High Exposures (> 1 Mg/msupporting

confidence: 88%

Section: Introductionsupporting

confidence: 45%

Health effects of manganese exposures for welders in Qingdao City, China

Zhang

Wang

et al. 2016

Int J Occup Med Environ Health

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“…Following overexposure in humans, however, it is neurotoxic (Crossgrove and Zheng, 2004) and produces manganism -a motor disorder with similarities to Parkinson's disease (Dobson et al, 2004;Aschner et al, 2005;Antonini et al, 2006;Cersosimo and Koller, 2006). The late-stage symptoms include generalized bradykinesia, widespread rigidity, and occasional resting tremor (Pal et al, 1999) and are thought to be related to an accumulation of manganese in the substructures of the basal ganglia, particularly the globus pallidus.…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI

et al. 2008

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Manganese overexposure in non-human primates and humans causes a neurodegenerative disorder called manganism thought to be related to an accumulation of the metal in the basal ganglia. Here, we assess changes in the concentration of manganese in regions of the brain of a non-human primate (the common marmoset, Callithrix jacchus) following four systemic injections of 30 mg/kg MnCl 2 ·H 2 0 in the tail vein using T 1 -weighted magnetic resonance imaging (MRI) and compare these to changes in the rat following the same exposure route and dose. The doses were spaced 48 hours apart and we imaged the animals 48 hours after the final dose. We find that marmosets have significantly larger T 1 -weighted image enhancements in regions of the brain compared to rats, notably in the basal ganglia and the visual cortex. To confirm this difference across species reflects actual differences in manganese concentrations and not variations in the MRI properties of manganese, we measured the longitudinal relaxivity of manganese (χ 1 ) in the in vivo brain and found no significant species' difference. The high manganese uptake in the marmoset basal ganglia and visual cortex can be explained by CSF-brain transport from the large lateral ventricles and we confirm this route of uptake with time-course MRI during a tail-vein infusion of manganese. There is also high uptake in the substructures of the hippocampus that are adjacent to the ventricles. The large manganese accumulation in these structures on overexposure may be common to all primates, including humans.

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“…The temperature during welding may reach up to 6000 °C and the melting point of the tungsten is about 3500 °C. Therefore, we can assume that tungsten may evaporate and form the finest particles (10-100 nm) by condensation 18 . Moreover, one glioblastoma (grade IV) of a patient working as a welder contained tungsten particles inside a red blood cell (Fig.…”

Section: Discussionmentioning

confidence: 99%

Detection of nano- and micro-sized particles in routine biopsy material - pilot study

Jana¹,

Bielniková²,

Kukutschová³

et al. 2015

BIOMED PAP

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Background. Nanotechnology is receiving enormous funding. Very little however is known about the health dangers of this technology so far. Chronic tonsillitis is one of a number of diseases called idiopathic. Among other factors, the tonsils are exposed to suspended particles in inhaled air including nano particles. The objective of this study was to detect and evaluate metallic particles in human tonsil tissue diagnosed with chronic tonsillitis and in amniotic fluid as a comparison. Methods. Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) was used for identification of solid particles in a total of 64 samples of routinely analyzed biopsy and cytologic material. Results. Almost all samples were found to contain solid particles of various metals. The most frequent, regardless of diagnosis, were iron, chromium, nickel and aluminium. The size, determined using SEM, varied from around 500 nm to 25 μm. The majority formed aggregates of several micrometers in size but there were a significant number of smaller (sub-micrometer or nano-sized) particles present. The incidence of metallic particles was similar in child and adult tissues. The difference was in composition: the presence of several metals in adults was due to occupational exposure. Conclusions. The presence of metallic particles in pathologically altered tissues may signal an alternative causation of some diseases. The ethiopathogenic explanation of these diseases associated with the presence of nano-sized particles in the organism has emerged into a new field of pathology, nanopathology.

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Fate of manganese associated with the inhalation of welding fumes: Potential neurological effects

Cited by 106 publications

References 38 publications

Health effects of manganese exposures for welders in Qingdao City, China

Health effects of manganese exposures for welders in Qingdao City, China

Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI

Detection of nano- and micro-sized particles in routine biopsy material - pilot study

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