Fate, occurrence, and toxicity of veterinary antibiotics in environment

Kumar, Ramasamy Rajesh; Lee, Jae Taek; Cho, Jae-Young

doi:10.1007/s13765-012-2220-4

Cited by 106 publications

(48 citation statements)

References 75 publications

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“…Many antibiotics are persistent in the environment, raising concerns of toxicity, resistance development, and other environmental risks (55). Avi is extensively metabolized in rats and pigs (56), at the orthoester C16 link.…”

Section: Avi and Evn Resistance Mechanismsmentioning

confidence: 99%

Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding

Krupkin

Wekselman

Matzov

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Two structurally unique ribosomal antibiotics belonging to the orthosomycin family, avilamycin and evernimicin, possess activity against Enterococci, Staphylococci, and Streptococci, and other Gram-positive bacteria. Here, we describe the high-resolution crystal structures of the eubacterial large ribosomal subunit in complex with them. Their extended binding sites span the A-tRNA entrance corridor, thus inhibiting protein biosynthesis by blocking the binding site of the A-tRNA elbow, a mechanism not shared with other known antibiotics. Along with using the ribosomal components that bind and discriminate the A-tRNA-namely, ribosomal RNA (rRNA) helices H89, H91, and ribosomal proteins (rProtein) uL16-these structures revealed novel interactions with domain 2 of the CTC protein, a feature typical to various Gram-positive bacteria. Furthermore, analysis of these structures explained how single nucleotide mutations and methylations in helices H89 and H91 confer resistance to orthosomycins and revealed the sequence variations in 23S rRNA nucleotides alongside the difference in the lengths of the eukaryotic and prokaryotic α1 helix of protein uL16 that play a key role in the selectivity of those drugs. The accurate interpretation of the crystal structures that could be performed beyond that recently reported in cryo-EM models provide structural insights that may be useful for the design of novel pathogen-specific antibiotics, and for improving the potency of orthosomycins. Because both drugs are extensively metabolized in vivo, their environmental toxicity is very low, thus placing them at the frontline of drugs with reduced ecological hazards. degradable antibiotics | ribosomes | resistance | species-specific antibiotics | Gram-positive

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Section: Avi and Evn Resistance Mechanismsmentioning

confidence: 99%

Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding

Krupkin

Wekselman

Matzov

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…Once released into the environment, they possibly impact on the development of multi‐resistant bacteria, with detrimental effects on human health as well as on the performance of naturally occurring nontarget species (Bártíkova et al., 2016; Jechalke, Heuer, Siemens, Amelung, & Smalla, 2014; Kumar, Lee, & Cho, 2012; Minden, Deloy, Volkert, Leonhardt, & Pufal, 2017). In plants, antibiotics can, among other effects, delay germination, reduce chlorophyll content and growth, and affect bioaccumulation (see summarizing tables in Bártíkova et al., 2016; Carvalho, Basto, Almeida, & Brix, 2014; Minden et al., 2017; Puckowski et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Antibiotics in the environment have been recognized as a serious threat to nontarget organisms as well as the entire ecosystem, and have been grouped, together with other pharmaceuticals and personal-care products, in a new group of chemicals termed "contaminants of emerging concern" (Bartrons & Peñuelas, 2017;Hyland, Blaine, Dickenson, & Higgins, 2015). Once released into the environment, they possibly impact on the development of multi-resistant bacteria, with detrimental effects on human health as well as on the performance of naturally occurring nontarget species (Bártíkova et al, 2016;Jechalke, Heuer, Siemens, Amelung, & Smalla, 2014;Kumar, Lee, & Cho, 2012;Minden, Deloy, Volkert, Leonhardt, & Pufal, 2017). In plants, antibiotics can, among other effects, delay germination, reduce chlorophyll content and growth, and affect bioaccumulation (see summarizing tables in Bártíkova et al, 2016;Carvalho, Basto, Almeida, & Brix, 2014;Minden et al, 2017;Puckowski et al, 2016).…”

mentioning

confidence: 99%

Antibiotic‐induced effects on scaling relationships and on plant element contents in herbs and grasses

Minden

Schnetger

Pufal

et al. 2018

Ecology and Evolution

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Plant performance is correlated with element concentrations in plant tissue, which may be impacted by adverse chemical soil conditions. Antibiotics of veterinary origin can adversely affect plant performance. They are released to agricultural fields via grazing animals or manure, taken up by plants and may be stored, transformed or sequestered by plant metabolic processes. We studied the potential effects of three antibiotics (penicillin, sulfadiazine, and tetracycline) on plant element contents (macro‐ and microelements). Plant species included two herb species (Brassica napus and Capsella bursa‐pastoris) and two grass species (Triticum aestivum and Apera spica‐venti), representing two crop species and two noncrop species commonly found in field margins, respectively. Antibiotic concentrations were chosen as to reflect in vivo situations, that is, relatively low concentrations similar to those detected in soils. In a greenhouse experiment, plants were raised in soil spiked with antibiotics. After harvest, macro‐ and microelements in plant leaves, stems, and roots were determined (mg/g). Results indicate that antibiotics can affect element contents in plants. Penicillin exerted the greatest effect both on element contents and on scaling relationships of elements between plant organs. Roots responded strongest to antibiotics compared to stems and leaves. We conclude that antibiotics in the soil, even in low concentrations, lead to low‐element homeostasis, altering the scaling relationships between roots and other plant organs, which may affect metabolic processes and ultimately the performance of a plant.

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“…Since Alexander Fleming firstly isolated the antibiotic penicillin from the fungus Penicillium in 1928 [1], over 3000 different antibiotics have been founded or synthesized and more than 100 antibiotics have been applied in human and veterinary medicine as a preventive or curative treatment for bacterial infections. According to the global antibiotic consumption 2000 to 2010 analysis, consumption of antibiotic drugs increased by 35%, and BRICs countries account for 76% of the increase [2].…”

Section: Introductionmentioning

confidence: 99%

Roots of Antibiotic’s Vicious Cycle through Aquatic Environment

Liu¹

2017

BJSTR

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Fate, occurrence, and toxicity of veterinary antibiotics in environment

Cited by 106 publications

References 75 publications

Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding

Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding

Antibiotic‐induced effects on scaling relationships and on plant element contents in herbs and grasses

Roots of Antibiotic’s Vicious Cycle through Aquatic Environment

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