Fate mapping study of the endoderm of the 1.5-day-old chick embryo

Matsushita, Susumu

doi:10.1007/bf00365800

Cited by 37 publications

(64 citation statements)

References 12 publications

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“…Our in vivo implantation study demonstrated that the mesoderm on the left side has the competence to respond to an ectopic liver budderived inductive influence, favoring the former possibility. However, before Wt1 and capsulin expression becomes detectable, progenitors of the liver bud are located bilaterally (Matsushita, 1996;Rosenquist, 1971), similar to those in mouse embryos (Tremblay and Zaret, 2005), in which PE develops bilaterally. Therefore, it is possible that non-liver tissues negatively regulate PE development specifically on the left side of the pericardial mesoderm, although nothing is known about an activity that antagonizes PE development.…”

Section: Inductive Interaction(s) Between the Liver Bud And Mesotheliumsupporting

confidence: 59%

“…The results presented in this study suggest a subsequent inductive event in which the liver bud induces the overlying mesothelium to initiate PE development. Thus, reciprocal tissue interactions and a differential movement of the mesoderm and endoderm (Matsushita, 1996) might be crucial in coordinating the generation of the myocardium and epicardial/coronary vessel precursors from neighboring regions of the mesoderm at different stages of development.…”

Section: Discussionmentioning

confidence: 99%

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Induction of proepicardial marker gene expression by the liver bud

et al. 2007

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Cells of the coronary vessels arise from a unique extracardiac mesothelial cell population, the proepicardium, which develops posterior to the sinoatrial region of the looping-stage heart. Although contribution of the proepicardial cells to cardiac development has been studied extensively, it remains unresolved how the proepicardium is induced and specified in the mesoderm during embryogenesis. It is known, however, that the proepicardium develops from the mesothelium that overlays the liver bud. Here, we show that the expression of proepicardial marker genes -Wt1, capsulin (epicardin, pod1, Tcf21) and Tbx18, can be induced in naïve mesothelial cells by the liver bud, both in vitro and in vivo. Lateral embryonic explants, when co-cultured with the liver bud, were induced to express these proepicardial marker genes. The same induction of the marker genes was detected in vivo when a quail liver bud was implanted in the posterior-lateral regions of a chick embryo. This ectopic induction of marker gene expression was not evident when other endodermal tissues, such as the lung bud or stomach, were implanted. This inductive response to the liver bud was not detectable in host embryos before stage 12 (16-somite stage). These results suggest that, after a specific developmental stage, a large area of the mesothelium becomes competent to express proepicardial marker genes in response to localized liver-derived signal(s). The developmentally regulated competency of mesothelium and a localized inductive signal might play a role in restricting the induction of the proepicardial marker gene expression to a specific region of the mesothelium. The data might also provide a foundation for future engineering of a coronary vascular progenitor population.

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Section: Inductive Interaction(s) Between the Liver Bud And Mesotheliumsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Induction of proepicardial marker gene expression by the liver bud

et al. 2007

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“…According to fate mapping experiments in the chick and to their maintenance during organogenesis, it can be inferred that they are restricted to the precursor fields of specific organs. In the 15-somite-stage chick, domains that contribute to various digestive organs do overlap although regions of different fates can be distinguished (Le Douarin, 1964b, Matsushita, 1996, Matsushita, 1999. There is only one fate mapping study at this stage in the mouse and it largely corroborates the chick data (Tremblay and Zaret, 2005).…”

Section: As Somites Form a Complex Gene Expression Map Prefigures Ormentioning

confidence: 57%

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

Grapin-Botton¹

2005

Int. J. Dev. Biol.

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This review is dedicated to the work on chick digestive tract organogenesis that Nicole Le Douarin performed as a PhD student under the direction of Etienne Wolf. I discuss how she laid the grounds for future work by establishing fate maps at somitic stages, by describing morphogenetic movements between germ layers and by pointing to signaling events between endoderm and mesoderm. Her inspiring work was extended by others, in particular at the molecular level, leading to a better understanding of antero-posterior patterning in the digestive tract. Antero-posterior patterning of endoderm is initiated at gastrulation when future anterior and posterior endoderm ingress at different times and accordingly express different genes. Plasticity is however maintained at somite stages and even later, when organ primordia can be delineated. There is a cross-talk between endoderm and mesoderm and the two layers exchange instructive signals that induce specific antero-posterior identities as well as permissive signals required for organogenesis from previously patterned fields. Recent experiments suggest that several signaling molecules involved in neural tube antero-posterior patterning are also instrumental in the digestive tract including retinoic acid and FGF4.

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“…1A), and thus only in partial contact with the dorsal pancreatic progenitor domain, which has been mapped to the endoderm adjacent to the notochord and underlying the somites (Matsushita, 1996;Kumar et al, 2003). By 12-15S, the aorta contacted the dorsal endoderm extensively, without intervening cells (Fig.…”

Section: Endothelial Cells Contact Nascent Dorsal But Not Ventral Pmentioning

confidence: 98%

Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a

2004

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Dorsal and ventral pancreatic bud development from the endoderm requires inductive interactions with diverse mesodermal cell types and the action of transcription factors expressed within the endoderm. Presently it is unclear which mesodermal interactions activate which pancreatic transcription factors,and whether such inductions are common for initiating dorsal and ventral pancreas development. Previous studies of Lammert et al. (Lammert, E.,Cleaver, O. and Melton, D. (2001) Science 294, 564-567) showed that signaling from embryonic blood vessel cells, derived from the mesoderm,promotes pancreatic bud development. Using a combination of mouse Flk1-/- embryos lacking endothelial cells and tissue recombination experiments, we discovered that the initial induction of dorsal endoderm cells positive for the pancreatic and duodenal transcription factor Pdx1 does not require aorta or endothelial cell interactions, but dorsal pancreatic bud emergence and the maintenance of Pdx1 expression does. Aortal endothelial cells induce the crucial pancreatic transcription factor Ptf1a in the dorsal pancreatic endoderm; whereas the vitelline veins, which are normally adjacent to the emerging ventral pancreatic bud, are unnecessary for ventral Ptf1a induction or for ventral pancreatic bud initiation. We find that the aorta cells themselves, apart from the blood supply, cause the induction of Ptf1a in dorsal endoderm explants. Thus, endothelial cell interactions specifically promote early dorsal pancreatic development, at least in part, by inducing Ptf1a+ pancreatic progenitors. Additionally, we find that endothelial cells are necessary for the induction of both the insulin and glucagon genes.

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Fate mapping study of the endoderm of the 1.5-day-old chick embryo

Cited by 37 publications

References 12 publications

Induction of proepicardial marker gene expression by the liver bud

Induction of proepicardial marker gene expression by the liver bud

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a

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