Fate and toxicity of silver nanoparticles in freshwater from laboratory to realistic environments: a review

Zhang, Weicheng; Song, Ke; Sun, Caiyun; Xu, Xiaoyan; Chen, Jibao; Yao, Lunguang

doi:10.1007/s11356-019-04150-0

Cited by 61 publications

(18 citation statements)

References 106 publications

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“…Several issues still need to be better addressed such as the capacity of AgNPs to enter the body themselves reaching the various body districts or if only the silver ions issuing from the NPs are absorbed and which chemical reactions undergo in the digestive tract based on their chemical composition [ 52 ]. Accordingly, it was observed that AgNPs capped with citrate and not, aggregate and partially react to form silver chloride during exposure to synthetic stomach fluid [ 72 , 73 ] and, the aggregation of nanoparticles is favoured by smaller diameters, prolonged period, as well as by the surface features of NPs [ 72 ]. Concerning the capacity of nanoparticles to interact with the biomolecules, the study of Marchiore et al [ 40 ] investigated the migration of added silver nanoparticles from antimicrobial edible coating to sausages.…”

Section: Discussionmentioning

confidence: 99%

Chemical Characterization and Quantification of Silver Nanoparticles (Ag-NPs) and Dissolved Ag in Seafood by Single Particle ICP-MS: Assessment of Dietary Exposure

Grasso

Ferrante

Arena³

et al. 2021

IJERPH

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This study provides a first insight on the chemical characterization and quantification of silver nanoparticles (AgNPs) and dissolved Ag in processed canned seafood products, where food-grade edible silver (E174) is not intentionally added nor is the nanoparticle contained in the food contact material. The aim was to evaluate the bioaccumulation potential of AgNPs and to contribute to the assessment of AgNPs and ionic Ag human dietary intake from processed seafood. It is known how seafood, and in particular pelagic fish, is a precious nutritional source of unsaturated fatty acids, protein, and different micronutrients. Nevertheless, it may cause possible health problems due to the intake of toxic compounds coming from environmental pollution. Among emerging contaminants, AgNPs are widely applied in several fields such as biomedicine, pharmaceutical, food industry, health care, drug-gene delivery, environmental study, water treatments, and many others, although its primary application is in accordance with its antimicrobial property. As a consequence, AgNPs are discharged into the aquatic environment, where the colloidal stability of these NPs is altered by chemical and physical environmental parameters. Its toxicity was demonstrated in in-vitro and in-vivo studies, although some findings are controversial because toxicity depends by several factors such as size, concentration, chemical composition, surface charge, Ag+ ions released, and hydrophobicity. The new emerging technique called single-particle inductively coupled plasma mass spectrometry (spICP-MS) was applied, which allows the determination of nanoparticle number-based concentration and size distribution, as well as the dissolved element. Our findings highlighted comparable mean sizes across all species analysed, although AgNPs concentrations partly follow a trophic level-dependent trend. The low mean size detected could be of human health concern, since, smaller is the diameter higher is the toxicity. Dietary intake from a meal calculated for adults and children seems to be very low. Although seafood consumption represents only a small part of the human total diet, our findings represent a first important step to understand the AgNPs dietary exposure of the human population. Further studies are needed to characterize and quantify AgNPs in a large number of food items, both processing and not, and where AgNPs are added at the industrial level. They will provide a realistic exposure assessment, useful to understand if AgNPs toxicity levels observed in literature are close to those estimable through food consumption and implement data useful for risk assessors in developing AgNPs provisional tolerable daily intake.

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Section: Discussionmentioning

confidence: 99%

Chemical Characterization and Quantification of Silver Nanoparticles (Ag-NPs) and Dissolved Ag in Seafood by Single Particle ICP-MS: Assessment of Dietary Exposure

Grasso

Ferrante

Arena³

et al. 2021

IJERPH

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“…Because we did not measure the DOM in this study, we cannot test this hypothesis. However, it has been reviewed by Zhang et al 34 that DOM can stabilize AgNPs in aqueous media by blocking oxidative sites, adhering on the surface of AgNPs, and reduce the toxicity of AgNPs to aquatic organisms. Therefore, three main pathways were identified in this review concerning the reduced toxicity of AgNPs in the presence of DOM: protecting organisms from the NPs itself, scavenging free radicals and combining DOM particles with released ionic silver.…”

Section: Discussionmentioning

confidence: 99%

Defective defence in Daphnia daughters: silver nanoparticles inhibit anti-predator defence in offspring but not in maternal Daphnia magna

Hartmann

Beasley

Mozhayeva

et al. 2020

Sci Rep

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One major environmental problem of our time are emerging contaminants in the aquatic environment. While nanoparticles exhibit attractive features such as antimicrobial properties in the case of silver nanoparticles (AgNPs), earlier studies suggest that NPs are not completely filtered out at wastewater treatment plants and may therefore be continuously introduced into the aquatic environment. Although adverse effects of AgNPs on aquatic organisms have been extensively studied, there is still a lack of knowledge on how this chemical stressor interacts with natural cues on the maternal and subsequent generation of aquatic organisms. We tested whether AgNPs (NM-300K, 14.9 ± 2.4 nm, concentration range: 2.5 µg/L-20 µg/L) affect the kairomone-induced adaptive anti-predator defence mechanism in maternal Daphnia and their offspring. While maternal Daphnia developed typical antipredator defence mechanisms when exposed to kairomones and AgNPs, their offspring could not develop such adaptive defensive traits. The lack of this defence mechanism in offspring could have dramatic negative consequences (e.g. reduced Daphnia population) for the entire complex food web in the aquatic ecosystem. For a realistic risk assessment, it is extremely important to test combinations of chemical stressors because aquatic organisms are exposed to several natural and artificial chemical stressors at the same time. Since the end of the 18th century, the industrial revolution has led to enormous technical, health and economic improvements for human welfare. However, technological progress is interfering with global cycles that could lead to negative changes in the environment 1. One major environmental problem of our time is the environmental pollution caused by mankind 1. In recent decades, pollution of the aquatic environment has risen to new levels 2 due to the release of synthetic or natural-occurring compounds found in pharmaceuticals, personal care products, industrial and household products, metals, and nanomaterials into aquatic ecosystems 1,2. One of the most commonly used nanomaterials are silver nanoparticles (AgNPs) due to their antimicrobial properties. Many medical products, such as wound dressings, bandages and sanitation devices use AgNPs 3. In addition, common household objects, food containers, and sports clothing contain AgNPs, and even washing machines are impregnated with AgNPs to reduce bacterial growth and odour 3. Based on their small size (less than 100 nm in size in one dimension), NPs are not completely filtered out at waste-water treatment plants (approximately 50 to 99% removal efficiency with regional variations and depending on the type of NP) 4 , and a significant amount of Ag-containing NPs is still continuously released into freshwater ecosystems 5. Maurer-Jones et al. 6 estimated that the predicted environmental concentrations (PECs) for AgNPs in surface water range from 0.088 to 10,000 ng/L. Besides the numerous studies on the negative effects of high concentrations of AgNPs on aquatic organisms such as Daphni...

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“…Silver nanoparticles are used as antimicrobials, and their use in dentistry has gained significance use as a promising platform for their use against tumors, inflammation, and a wide range of microbes [49]. However, though silver has gained significance, bare silver nanoparticles are toxic to the system, and due to this, it is difficult to extrapolate the in vitro activity to in vivo activity [50][51][52]. Thus, silver nanoparticles are functionalized or incorporated in carrier systems like chitosan, gelatin, dendrimer, protein, etc., to reduce toxicity and increase efficacy.…”

Section: Preparation and Characterization Of Silver Nanoparticles (Agnps)mentioning

confidence: 99%

Fabrication of Dexamethasone-Silver Nanoparticles Entrapped Dendrimer Collagen Matrix Nanoparticles for Dental Applications

2021

Biointerface Res Appl Chem

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A bioengineered tooth is a well-studied subject. However, it is a challenge when seamless integration of various functionalities is required. In the case of teeth, integrating stem cell differentiating agents, regenerating the dentin tissue, and arresting the biofilm formation are three aspects that call for attention. Dental pulp stem cell differentiation to odontoblasts can be facilitated by dexamethasone (Dex). The ideal scaffold for regeneration applications – collagen (Col), has several advantages but also has no inherent rigidity. Silver nanoparticles (AgNps) are found to be an ideal material for preventing biofilm formation, with challenges arising from their stability and cytotoxicity. The route was chosen based on the successful demonstration of various platforms is the PAMAM (Den) dendrimers. The platform encompassing all the ingredients – AgNp@Den@Dex@Col had a max at 622 nm. FTIR studies revealed the presence of all components, and scaffold degradation temperature improved. A linked morphology was observed under TEM, and the zone of inhibition (MIC) was 3.5 mm, indicating good antibacterial activity. There was also a 60% reduction in biofilm formation against Staphylococcus aureus and 40% against Klebsiella pneumoniae by the fabricated nanocomposite AgNp@Den@Dex@Col. In essence, this work reports a platform where three functions of stem cell differentiation, regeneration, and biofilm formation are integrated.

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Fate and toxicity of silver nanoparticles in freshwater from laboratory to realistic environments: a review

Cited by 61 publications

References 106 publications

Chemical Characterization and Quantification of Silver Nanoparticles (Ag-NPs) and Dissolved Ag in Seafood by Single Particle ICP-MS: Assessment of Dietary Exposure

Chemical Characterization and Quantification of Silver Nanoparticles (Ag-NPs) and Dissolved Ag in Seafood by Single Particle ICP-MS: Assessment of Dietary Exposure

Defective defence in Daphnia daughters: silver nanoparticles inhibit anti-predator defence in offspring but not in maternal Daphnia magna

Fabrication of Dexamethasone-Silver Nanoparticles Entrapped Dendrimer Collagen Matrix Nanoparticles for Dental Applications

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