Fate and effects of the residues of anticancer drugs in the environment

Heath, Ester; Filipič, Metka; Kosjek, Tina; Isidori, Marina

doi:10.1007/s11356-016-7069-3

Cited by 55 publications

(35 citation statements)

References 18 publications

(15 reference statements)

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“…Therefore, when the public pays low or no attention to an issue, policy under-reactions are the most likely outcome. This point is illustrated by the issue of drug residue cocktails in water bodies, which were found to pose a risk to aquatic organisms and may even harm human health (Heath, Filipič, Kosjek, & Isidori, 2016). Nonetheless, there have been limited calls from the public to regulate this risk.…”

Section: The Causes Of Disproportionate Policy Responsesmentioning

confidence: 99%

Proportionate and disproportionate policy responses to climate change: core concepts and empirical applications

Maor

Tosun

Jordan

2017

Journal of Environmental Policy & Planning

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A fresh perspective on policy-making and planning has emerged which views disproportionate policy as an intentional policy response. A disproportionate policy response is understood to be a lack of 'fit' or balance between the costs of a public policy and the benefits that are derived from this policy, and between policy ends and means. This paper applies this new perspective on the proportionality of policy-making to the area of climate change. The first part of the paper discusses the underlying causes of disproportionate policy responses in broad terms and then applies the theoretical reasoning to understand the conditions in which they are likely to appear in relation to climate change. These conditions are hypothesized to relate to four main factors: economic considerations; levels of public demand; focusing events; and strategic considerations. It concludes with the suggestion that societal actors may be able to manipulate these four factors to encourage politicians to adopt policies that mitigate climate change more rapidly than is currently the case in most countries. ARTICLE HISTORY

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Section: The Causes Of Disproportionate Policy Responsesmentioning

confidence: 99%

Proportionate and disproportionate policy responses to climate change: core concepts and empirical applications

Maor

Tosun

Jordan

2017

Journal of Environmental Policy & Planning

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“…An inherent consequence of the increase in cancer incidence is the constant search for new, effective solutions, the increase in the consumption of anticancer drugs (ADs) [ 3 , 5 ], and the risk of introducing more of these substances into natural ecosystems. These drugs, due to their non-specific mode of action, as well as mutagenic, carcinogenic, cyto- and genotoxic properties, disrupting the functioning of the endocrine system in eukaryotic cells, should be given greater and special attention because information on their potential risk to both humans and the environment is still limited [ 3 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Insight into the Sorption of 5-Fluorouracil and Methotrexate onto Soil–pH, Ionic Strength, and Co-Contaminant Influence

et al. 2021

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Nowadays anticancer drugs (ADs), like other pharmaceuticals, are recognized as new emerging pollutants, meaning that they are not commonly monitored in the environment; however, they have great potential to enter the environment and cause adverse effects there. The current scientific literature highlights the problem of their presence in the aquatic environment by publishing more and more results on their analytics and ecotoxicological evaluation. In order to properly assess the risk associated with the presence of ADs in the environment, it is also necessary to investigate the processes that are important in understanding the environmental fate of these compounds. However, the state of knowledge on mobility of ADs in the environment is still very limited. Therefore, the main aim of our study was to investigate the sorption potential of two anticancer drugs, 5-fluorouracil (5-FU) and methotrexate (MTX), onto different soils. Special attention was paid to the determination of the influence of pH and ionic strength as well as presence of co-contaminants (cadmium (Cd2+) and another pharmaceutical—metoprolol (MET)) on the sorption of 5-FU and MTX onto soil. The obtained distribution coefficient values (Kd) ranged from 2.52 to 6.36 L·kg−1 and from 6.79 to 12.94 L·kg−1 for 5-FU and MTX, respectively. Investigated compounds may be classified as slightly or low mobile in the soil matrix (depending on soil). 5-FU may be recognized as more mobile in comparison to MET. It was proved that presence of other soil contaminants may strongly influence their mobility in soil structures. The investigated co-contaminant (MET) caused around 25-fold increased sorption of 5-FU, whereas diminished sorption of MTX. Moreover, the influence of environmental conditions such as pH and ionic strength on their sorption has been clearly demonstrated.

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“…Presence of these compounds in aqueous environment poses severe threat and may even cause genetic diseases upon consumption. Therefore it is critical to detect their presence and to quantify them in environmental samples .…”

Section: Introductionmentioning

confidence: 99%

“…Cytostatic compounds are delivered into the environment from different sources such as hospital effluent and municipal effluent of outpatients [3][4][5][6]. The occurrence of cytostatic compound and other pharmaceutical drugs have been widely reported in the aqueous environment [5,[7][8][9][10][11][12]. Cytostatic compound's presence in the environment is a potential threat [13].…”

Section: Introductionmentioning

confidence: 99%

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Development of cost‐effective RP‐HPLC methods for detection of cyclophosphamide, etoposide and paclitaxel

Yadav

Pandey

Mandal

et al. 2020

Separation Science Plus

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Quantification of cyclophosphamide, palcitaxel and etoposide in water sample using simple analytical technique is challenging. In this study, we have developed a simple, sensitive, robust and accurate method for the detection and quantification of cyclophosphamide, etoposide, and paclitaxel using high‐performance liquid chromatography and validated the same. The analytical conditions were achieved by the high‐performance liquid chromatography system on a C18 column (250 mm × 4.6 mm × 5 µm) under isocratic mode. The retention time for cyclophosphamide, paclitaxel and etoposide were 2:40.1, 3:32.3 and 3:49.3 min respectively. We validated the method by evaluating system sensitivity and linearity. We anticipate the method to be useful in quantification of cyclophosphamide, paclitaxel and etoposide in water sample.

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Fate and effects of the residues of anticancer drugs in the environment

Cited by 55 publications

References 18 publications

Proportionate and disproportionate policy responses to climate change: core concepts and empirical applications

Proportionate and disproportionate policy responses to climate change: core concepts and empirical applications

Insight into the Sorption of 5-Fluorouracil and Methotrexate onto Soil–pH, Ionic Strength, and Co-Contaminant Influence

Development of cost‐effective RP‐HPLC methods for detection of cyclophosphamide, etoposide and paclitaxel

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