Fate and behaviour of veterinary sulphonamides under denitrifying conditions

Bílková, Zuzana; Malá, Jitka; Hrich, Karel

doi:10.1016/j.scitotenv.2019.133824

Cited by 45 publications

(10 citation statements)

References 77 publications

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“…These three approaches have in common the fact that they use pharmaceuticals that are now considered to be hazardous environmental contaminants. In particular, the use of these substances in large quantities in livestock therapy poses a heavy burden to the environment and high risks for ecosystems [7][8][9][10]. On the other hand, returning to medicinal plants and their products, which is the fourth alternative approach to control helminthiasis, represents an environmentally friendly way.…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic activity of European fern extracts against Haemonchus contortus

Pavičić

Zajíčková

Šadibolová

et al. 2023

Preprint

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Most drugs used in the treatment of helminthiasis in humans and animals have lost their efficacy due to the development of drug-resistance in helminths. Moreover, since anthelmintics, like many pharmaceuticals, are now recognized as hazardous contaminants of the environment, returning to medicinal plants and their products represents an environmentally friendly way to treat helminthiasis. The goal of the present study was to test the anthelminthic activity of methanol extracts of eight selected European ferns from the genera Dryopteris, Athyrium and Blechnum against the nematode Haemonchus contortus, a widespread parasite of small ruminants. Eggs and adults of H. contortus drug-susceptible strain ISE and drug-resistant strain WR were isolated from experimentally infected sheep. The efficacy of fern extracts was assayed using egg hatch test and adults viability test based on ATP-level measurement. Among the ferns tested, only Dryopteris aemula extract (0.2 mg/ml) inhibited eggs hatching by 25% in comparison to control. Athyrium distentifolium, Dryopteris aemula and Dryopteris cambrensis were effective against H. contortus adults. In concentration 0.1 mg/ml, A. distentifolium, D. aemula, D. cambrensis significantly decreased the viability of females from ISE and WR strains to 36.2%, 51.9%, 32.9% and to 35.3%, 27.0%, 23.6, respectively in comparison to untreated controls. None of the extracts exhibited toxicity in precise cut slices from ovine liver. Polyphenol’s analysis identified quercetin, kaempferol, luteolin, 3-hydroxybenzoic acid, caffeic acid, coumaric acid and protocatechuic acid as the major components of these anthelmintically active ferns.

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Section: Introductionmentioning

confidence: 99%

Anthelmintic activity of European fern extracts against Haemonchus contortus

Pavičić

Zajíčková

Šadibolová

et al. 2023

Preprint

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“…To some extent, changes in the abundance of N transforming functional genes may reflect the occurrence of available N in soils. For example, sulphonamides inhibit the expression of individual denitrification genes, thus causing accumulation or loss of NO 3 – -N in soil . Given the above, we hypothesize that differences in microbe-driven rhizosphere N transformation among choysum varieties play an important role in the variety-specific CIP uptake and bioaccumulation in choysum.…”

Section: Introductionmentioning

confidence: 99%

Mechanism and Association between Microbial Nitrogen Transformation in Rhizosphere and Accumulation of Ciprofloxacin in Choysum (Brassica parachinensis)

Yan,

Xiang,

Zhang

et al. 2023

Environ. Sci. Technol.

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Rhizosphere microbiota are an important factor impacting plant uptake of pollutants. However, little is known about how microbial nitrogen (N) transformation in the rhizosphere affects the uptake and accumulation of antibiotics in plants. Here, we determined recruitment of N transformation functional bacteria upon ciprofloxacin (CIP) exposure, by comparing differences in assembly processes of both rhizospheric bacterial communities and N transformation between two choysum (Brassica parachinensis) varieties differing in CIP accumulation. The low accumulation variety (LAV) of CIP recruited more host bacteria (e.g., Nitrospiria and Nitrolancea) carrying nitrification genes (mainly nxrA) but fewer host bacteria carrying denitrification genes, especially narG, relative to the high accumulation variety (HAV) of CIP. The nxrA and narG abundance in the LAV rhizosphere were, respectively, 1.6−7.8 fold higher and 1.4−3.4 fold lower than those in the HAV rhizosphere. Considering that nitrate can decrease CIP uptake into choysum through competing for the proton motive force and energy, such specific bacteria recruitment in LAV favored the production and utilization of nitrate in its rhizosphere, thus limiting its CIP accumulation with 1.6−2.4 fold lower than the HAV. The findings give insight into the mechanism underlying low pollutant accumulation, filling the knowledge gap regarding the profound effects of rhizosphere microflora and N transformation processes on antibiotic accumulation in crops.

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“…In this sense, denitrification has been successfully used for eliminating aromatic compounds, 29 chlorinated contaminants 30 and mixtures of 2-chlorophenol (2-CP) with phenol, glucose and acetate as external electron donors, 31 as well as mixtures of emerging contaminants such as personal care products, hormones, different classes of pharmaceuticals and pesticides, among others. 32,33 There are some reports in the literature concerning the elimination of antibiotics under denitrifying conditions. For example, elimination between 15% and 20% of erythromycin and sulfamethoxazole has been documented.…”

Section: Introductionmentioning

confidence: 99%

Physiological and kinetic evaluation of ampicillin oxidation as unique electron source by a denitrifying sludge

Yeny

Texier

Flor

2022

J of Chemical Tech & Biotech

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BACKGROUND Denitrification allows the simultaneous oxidation of recalcitrant compounds and the reduction of nitrate. Scarce information on consumption and oxidation of ampicillin (AMP) as sole electron source is found in the literature. The physiological and kinetic ability of a denitrifying sludge without previous exposure to antibiotics for oxidizing several AMP concentrations was evaluated. RESULTS Complete denitrification was accomplished in batch reference assays with acetate (20–100 mg C L−1) and nitrate (C/N 1.1) within 4 h of culture, resulting in yields of HCO3− (YHCO3−) and N2 (YN2) of 0.89–1.0 mg C or N produced mg−1 C or N consumed, respectively. Assays amended with different concentrations of AMP (5–100 mg C L−1) as unique electron source at stoichiometric C/N ratio (0.86) showed that within 8–12 h of culture the antibiotic was totally consumed and oxidized to HCO3− and CO2 (YHCO3− between 0.27 and 0.67 and YCO2 between 0.35 and 0.54 mg C produced mg−1 C consumed), while nitrate was mostly reduced to N2 (YN2 = 0.77–1.0 mg N produced mg−1 N consumed). At AMP concentrations higher than 20 mg C L−1, N2O and carbon intermediates production was detected. Decreases of 20–90% in denitrifying specific rates were determined regarding the denitrifying reference. After exposure to the antibiotic, the sludge was able to recover its denitrifying activity in the absence of AMP with no N2O accumulation, whereas only 39% of the denitrification rates were recuperated. CONCLUSION It was clearly evidenced that AMP was used as electron donor for conducting denitrification; however, the denitrifying process occurred at lower specific rates. © 2021 Society of Chemical Industry (SCI).

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Fate and behaviour of veterinary sulphonamides under denitrifying conditions

Cited by 45 publications

References 77 publications

Anthelmintic activity of European fern extracts against Haemonchus contortus

Anthelmintic activity of European fern extracts against Haemonchus contortus

Mechanism and Association between Microbial Nitrogen Transformation in Rhizosphere and Accumulation of Ciprofloxacin in Choysum (Brassica parachinensis)

Physiological and kinetic evaluation of ampicillin oxidation as unique electron source by a denitrifying sludge

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