Fate, activity, and impact of ingested bacteria within the human gut microbiota

Derrien, Muriel; Vlieg, Johan E. T. van Hylckama

doi:10.1016/j.tim.2015.03.002

Cited by 478 publications

(408 citation statements)

References 136 publications

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“…lactis deserves a special mention (25). Members of this bifidobacterial species can transit and impact resident microbial communities even if their overall effects are still not well defined (66)(67)(68). Notably, members of the B. animalis subsp.…”

Section: Figmentioning

confidence: 99%

Genomics of the Genus Bifidobacterium Reveals Species-Specific Adaptation to the Glycan-Rich Gut Environment

Milani

Turroni

Duranti

et al. 2016

Appl Environ Microbiol

183

145

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b Bifidobacteria represent one of the dominant microbial groups that occur in the gut of various animals, being particularly prevalent during the suckling period of humans and other mammals. Their ability to compete with other gut bacteria is largely attributed to their saccharolytic features. Comparative and functional genomic as well as transcriptomic analyses have revealed the genetic background that underpins the overall saccharolytic phenotype for each of the 47 bifidobacterial (sub)species representing the genus Bifidobacterium, while also generating insightful information regarding carbohydrate resource sharing and crossfeeding among bifidobacteria. The abundance of bifidobacterial saccharolytic features in human microbiomes supports the notion that metabolic accessibility to dietary and/or host-derived glycans is a potent evolutionary force that has shaped the bifidobacterial genome.

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Section: Figmentioning

confidence: 99%

Genomics of the Genus Bifidobacterium Reveals Species-Specific Adaptation to the Glycan-Rich Gut Environment

Milani

Turroni

Duranti

et al. 2016

Appl Environ Microbiol

183

145

View full text Add to dashboard Cite

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“…Contradictory results have also been obtained (8), possibly owing to differences in the microbial strain used, the number of viable cells administered, and the product formulation. Furthermore, the deep complexity and profound variability of microbiota composition among subjects can hinder the recognition of actual modifications.…”

mentioning

confidence: 99%

Consumption of a Bifidobacterium bifidum Strain for 4 Weeks Modulates Dominant Intestinal Bacterial Taxa and Fecal Butyrate in Healthy Adults

Gargari

Taverniti

Balzaretti

et al. 2016

Appl Environ Microbiol

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Modulation of the intestinal microbial ecosystem (IME) is a useful target to establish probiotic efficacy in a healthy population. We conducted a randomized, double-blind, crossover, and placebo-controlled intervention study to determine the impact of Bifidobacterium bifidum strain Bb on the IME of adult healthy volunteers of both sexes. High-throughput 16S rRNA gene sequencing was used to characterize the fecal microbiota before and after 4 weeks of daily probiotic cell consumption. The intake of approximately one billion live B. bifidum cells affected the relative abundance of dominant taxa in the fecal microbiota and modulated fecal butyrate levels. Specifically, Prevotellaceae (P ‫؍‬ 0.041) and Prevotella (P ‫؍‬ 0.034) were significantly decreased, whereas Ruminococcaceae (P ‫؍‬ 0.039) and Rikenellaceae (P ‫؍‬ 0.010) were significantly increased. We also observed that the probiotic intervention modulated the fecal concentrations of butyrate in a manner dependent on the initial levels of short-chain fatty acids (SCFAs). In conclusion, our study demonstrates that a single daily administration of Bifidobacterium bifidum strain Bb can significantly modify the IME in healthy (not diseased) adults. These findings demonstrate the need to reassess the notion that probiotics do not influence the complex and stable IME of a healthy individual. IMPORTANCEFoods and supplements claimed to contain health-promoting probiotic microorganisms are everywhere these days and mainly intended for consumption by healthy people. However, it is still debated what actual effects probiotic products may have on the healthy population. In this study, we report the results of an intervention trial aimed at assessing the modifications induced in the intestinal microbial ecosystem of healthy adults from the consumption of a probiotic product. Our results demonstrate that the introduction of a probiotic product in the dietary habits of healthy people may significantly modify dominant taxa of the intestinal microbiota, resulting in the modulation of short-chain fatty acid concentrations in the gut. The overall changes witnessed in the probiotic intervention indicate a mechanism of microbiota modulation that could have potential effects on human health.

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“…Metagenomic analyses are being used to identify the various bacteria and even viruses in our foods (e.g., in Kimchi a fermented traditional Korean food Jung et al 2011). Food-borne bacteria can interact with the resident microbiota in various ways, both directly and indirectly (e.g., supplying metabolites or stimulating mucin production, which would then affect resident mucosa-associated bacteria), and, thus, have effects on their fitness (Derrien and van Hylckama Vlieg 2015).In fact, some argue that fermented foods could serve as experimentally tractable systems to study microbial community assembly, dynamics and invasibility (Wolfe and Dutton 2015).…”

Section: Probiotics and Food-borne Invadersmentioning

confidence: 99%

Invasions of Host-Associated Microbiome Networks

Murall

Abbate

Touzel

et al. 2017

Networks of Invasion: Empirical Evidence and Case Studies

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International audienceThe study of biological invasions of ecological systems has much to offer research on within–host (WH) systems, particularly for understanding infections and developing therapies using biological agents. Thanks to the ground-work established in other fields, such as community ecology and evolutionary biology, and to modern methods of measurement and quantification, the study of microbiomes has quickly become a field at the forefront of modern systems biology. Investigations of host-associated microbiomes (e.g. for studying human health) are often centred on measuring and explaining the structure, functions and stability of these communities. This momentum promises to rapidly advance our understanding of ecological networks and their stability, resilience and resistance to invasions. However, intrinsic properties of host-associated microbiomes that differ from those of free-living systems present challenges to the development of a WH invasion ecology framework. The elucidation of principles underlying the invasibility of WH networks will ultimately help in the development of medical applications and help shape our understanding of human health and disease

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Fate, activity, and impact of ingested bacteria within the human gut microbiota

Cited by 478 publications

References 136 publications

Genomics of the Genus Bifidobacterium Reveals Species-Specific Adaptation to the Glycan-Rich Gut Environment

Genomics of the Genus Bifidobacterium Reveals Species-Specific Adaptation to the Glycan-Rich Gut Environment

Consumption of a Bifidobacterium bifidum Strain for 4 Weeks Modulates Dominant Intestinal Bacterial Taxa and Fecal Butyrate in Healthy Adults

Invasions of Host-Associated Microbiome Networks

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