Fatality rate of COVID-19 in patients with malignancies: a sytematic review and meta-analysis

Afshar, Zeinab Mohseni; Dayani, Maliheh; Naderi, Mehdi; Ghanbarveisi, Farnia; Shiri, Samira; Rajati, Fatemeh

doi:10.1016/j.jinf.2020.05.062

Cited by 19 publications

(19 citation statements)

References 4 publications

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“…Cancer patients have been described as one of the most susceptible groups in the COVID-19 pandemic, having shown so far a high mortality ratio (7)(8)(9). Specifically, patients with hematologic cancers (leukemia, myeloma and lymphoma), lung cancer, or metastatic cancer (stage IV) had the uppermost frequency of severe events, described as a condition requiring admission to an intensive care unit, the use of mechanical ventilation, or death (82).…”

Section: The Role Of Btk In Covid-19 Patients With Cancermentioning

confidence: 99%

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Relevance of the Bruton Tyrosine Kinase as a Target for COVID-19 Therapy

Rada¹,

Qusairy

Massip-Salcedo

et al. 2020

Molecular Cancer Research

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The outbreak of the novel coronavirus disease 2019 has emerged as one of the biggest global health threats worldwide. As of October 2020, over 44 million confirmed cases and more than 1,160,000 deaths have been reported globally, and the toll is likely to be much higher before the pandemic is over. There are currently little therapeutic options available and new potential targets are intensively investigated. Recently, Bruton Tyrosine Kinase (BTK) has emerged as an interesting candidate. Elevated levels of BTK activity have been reported in blood monocytes from patients with severe COVID-19, compared to those from healthy volunteers. Importantly, various studies confirmed empirically that administration of BTK inhibitors (Acalabrutinib and Ibrutinib) decreased the duration of mechanical ventilation and mortality rate for hospitalized patients with severe COVID-19. Herein, we review the current information regarding the role of BTK in SARS-CoV-2 infections and the suitability of its inhibitors as drugs to treat COVID-19. Implications:The use of BTK inhibitors in the management of COVID-19 shows promise in reducing the severity of the immune response to the infection and thus mortality. However, BTK inhibition may be contributing in other ways to inhibit the effects of the virus and this will need to be carefully studied.

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Section: The Role Of Btk In Covid-19 Patients With Cancermentioning

confidence: 99%

“…Various studies demonstrated that cancer patients are at high risk of COVID-19 complication and mortality comparing to the general population (7)(8)(9). Importantly, patients with hematologic malignancies have shown highest levels of mortality from COVID-19 comparing to the rest of cancers (10).…”

Section: Introductionmentioning

confidence: 99%

Relevance of the Bruton Tyrosine Kinase as a Target for COVID-19 Therapy

Rada¹,

Qusairy

Massip-Salcedo

et al. 2020

Molecular Cancer Research

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“…Despite the widespread reach of the COVID‐19's pandemic, children are an often‐overlooked population due to their lower mortality rates 8–10 . For instance, one study has reported a mortality rate of 0.03 per 100 000 deaths among children aged 0–9 years, 11 with some countries having rates as low as 0.18%, 12 as compared with mortality rates exceeding 10% among adults 12–14 . However, child welfare organisations have warned that the various lockdown measures will lead to more cases of child sexual, physical and emotional abuse and neglect 15 .…”

mentioning

confidence: 99%

Increased child abuse in Uganda amidst COVID‐19 pandemic

Sserwanja¹,

Kawuki

Kim

2020

J Paediatrics Child Health

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Globally, COVID‐19 lockdown measures have exposed children to more sexual, physical and emotional abuse and neglect. Although the COVID‐19 pandemic is likely to have long‐lasting adverse psychological effects on children, there have been comparatively few studies on children's health as compared with adults, particularly in low‐income countries. Uganda implemented one of the most stringent lockdowns with bans on transportation and gatherings as well as the closure of schools, stores and places of worship. In order to address the dearth of information in less developed regions, the article aims to provide an insight into the increased cases of child abuse in Uganda during the COVID‐19 pandemic. The data and information were primarily compiled from government and child welfare organisation open‐source databases. The psychosocial impacts of COVID‐19 have greatly disrupted the living conditions of children, limiting their access to basic needs such as food and health care. In addition, there is a lack of social support, thus putting children at an increased risk of different forms of child abuse. Since the implementation of the COVID‐19 lockdown in Uganda, there has been a rise in the incidence of child abuse. Increased cases of physical and sexual abuse against children have been reported in different parts of the country as well as increased cases of child labour. To strengthen child protection during the COVID‐19 pandemic, this article highlights a need for multi‐level stakeholder cooperation to ensure increased funding, increased community awareness and sensitisation, early detection and effective management and referral of child abuse cases.

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“…However, the high mortality rate in cancer patients who become infected with the new coronavirus must be taken into account. Afshar et al consider the fatality rate as between 5.5% and 60% in this group of patients without specifying the type of cancer [17][18][19][20][21][22].…”

Section: Locally Advanced Head and Neck Cancer Treatment In Covid-19 mentioning

confidence: 99%

New Challenges of Treatment for Locally Advanced Head and Neck Cancers in the Covid-19 Pandemic Era

Mireștean

Crişan

Mitrea

et al. 2021

JCM

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Locally advanced head and neck cancer is a unique challenge for cancer management in the Covid-19 situation. The negative consequences of delaying radio-chemotherapy treatment make it necessary to prioritize these patients, the continuation of radiotherapy being indicated even if SARS-CoV-2 infection is confirmed in the case of patients with moderate and mild symptoms. For an early scenario, the standard chemo-radiotherapy using simultaneous integrated boost (SIB) technique is the preferred option, because it reduces the overall treatment time. For a late scenario with limited resources, hypo-fractionated treatment, with possible omission of chemotherapy for elderly patients and for those who have comorbidities, is recommended. Concurrent chemotherapy is controversial for dose values >2.4 Gy per fraction. The implementation of hypo-fractionated regimens should be based on a careful assessment of dose-volume constraints for organs at risks (OARs), using recommendations from clinical trials or dose conversion based on the linear-quadratic (LQ) model. Induction chemotherapy is not considered the optimal solution in this situation because of the risk of immunosuppression even though in selected groups of patients TPF regimen may bring benefits. Although the MACH-NC meta-analysis of chemotherapy in head and neck cancers did not demonstrate the superiority of induction chemotherapy over concurrent chemoradiotherapy, an induction regimen could be considered for cases with an increased risk of metastasis even in the case of a possible Covid-19 pandemic scenario.

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Fatality rate of COVID-19 in patients with malignancies: a sytematic review and meta-analysis

Cited by 19 publications

References 4 publications

Relevance of the Bruton Tyrosine Kinase as a Target for COVID-19 Therapy

Relevance of the Bruton Tyrosine Kinase as a Target for COVID-19 Therapy

Increased child abuse in Uganda amidst COVID‐19 pandemic

New Challenges of Treatment for Locally Advanced Head and Neck Cancers in the Covid-19 Pandemic Era

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