Fatality after deliberate ingestion of sustained-release ibuprofen: a case report

Wood, David M.; Monaghan, Jane; Streete, Peter; Jones, Alison L

doi:10.1186/cc4850

Cited by 44 publications

(10 citation statements)

References 13 publications

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“… 23 – 42 Fatalities subsequent to ingestion of NSAIDs are frequently complicated by coingestants, although fatalities in lone NSAID ingestions have been reported. 43 …”

Section: Patterns Of Toxicity In Acute Nsaid Overdosementioning

confidence: 99%

“…Urine output remained satisfactory throughout the admission 5 mL/kg/hr and renal function had returned to normal within 72 hours, with no subsequent complications. 43 …”

Section: Biochemical Abnormalities In Acute Nsaid Overdosementioning

confidence: 99%

“…However there have been five reports in which it appears that NSAID overdose was the primary cause of death: this includes four cases of ibuprofen overdose and one case of indomethacin overdose. 14 , 20 , 43 , 51 , 52…”

Section: Fatalities In Acute Nsaid Overdosementioning

confidence: 99%

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The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose

Hunter

Wood

2011

OAEM

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The nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, anti-inflammatory and antipyretic actions. They are commonly taken in overdose in many areas of the world. The majority of patients with acute NSAID overdose will remain asymptomatic or develop minor self-limiting gastrointestinal symptoms. However, serious clinical sequelae have been reported in patients with acute NSAID overdose and these include convulsions, metabolic acidosis, coma and acute renal failure. There appear to be some differences between the NSAIDs in terms of the relative risk of these complications; in particular mefenamic acid is most commonly associated with convulsions. The management of these serious clinical features is largely supportive and there are no specific antidotes for acute NSAID toxicity.

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“… 23 – 42 Fatalities subsequent to ingestion of NSAIDs are frequently complicated by coingestants, although fatalities in lone NSAID ingestions have been reported. 43 …”

Section: Patterns Of Toxicity In Acute Nsaid Overdosementioning

confidence: 99%

“…Urine output remained satisfactory throughout the admission 5 mL/kg/hr and renal function had returned to normal within 72 hours, with no subsequent complications. 43 …”

Section: Biochemical Abnormalities In Acute Nsaid Overdosementioning

confidence: 99%

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The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose

Hunter

Wood

2011

OAEM

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“…Ibuprofen, a BCS (Biopharmaceutical Classification System) class II molecule, was chosen as the model hydrophobic drug for this study. Ibuprofen (IBU) is a non-steroidal anti-inflammatory drug (NSAID) widely used as an analgesic, anti-inflammatory, and anti-pyretic agent, with poor solubility in water (21)(22)(23). The oral administration of IBU can lead to gastrointestinal side effects, such as gastric erosion, peptic ulcer, and bleeding (24,25).…”

Section: Introductionmentioning

confidence: 99%

Soy Protein Microparticles for Enhanced Oral Ibuprofen Delivery: Preparation, Characterization, and In Vitro Release Evaluation

et al. 2017

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The objective of this work was to evaluate soy protein isolate (SPI) and acylated soy protein (SPA) as spray-drying encapsulation carriers for oral pharmaceutical applications. SPI acylation was performed by the Schotten-Baumann reaction. SPA, with an acylation rate of 41%, displayed a decrease in solubility in acidic conditions, whereas its solubility was unaffected by basic conditions. The drug encapsulation capacities of both SPI and SPA were tested with ibuprofen (IBU) as a model poorly soluble drug. IBU-SPI and IBU-SPA particles were obtained by spray-drying under eco-friendly conditions. Yields of 70 to 87% and microencapsulation efficiencies exceeding 80% were attained for an IBU content of 20 to 40% w/w, confirming the excellent microencapsulation properties of SPI and the suitability of the chemical modification. The in vitro release kinetics of IBU were studied in simulated gastrointestinal conditions (pH 1.2 and pH 6.8, 37°C). pH-sensitive release patterns were observed, with an optimized low rate of release in simulated gastric fluid for SPA formulations, and a rapid and complete release in simulated intestinal fluid for both formulations, due to the optimal pattern of pH-dependent solubility for SPA and the molecular dispersion of IBU in soy protein. These results demonstrate that SPI and SPA are relevant for the development of pH-sensitive drug delivery systems for the oral route.

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“…Self-medication when adolescents do not follow the recommended dosage might cause liver failure and hepatocellular necrosis when paracetamol is taken in overdose [15] [16] [17]. Several studies have shown that ibuprofen (ibux) can give gastrointestinal symptoms [18] [19] [20] [21], cardiovascular [22] and renal events [23].…”

mentioning

confidence: 99%

Gender Differences in Usage of Over-the-Counter Analgesics among Norwegian Adolescents

Lorentzen¹,

Lorentzen²,

Wikström³

2018

OJN

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Introduction: Usage of over-the-counter (OTC) analgesic has increased among Norwegian adolescents since 2001. It has been noted that females tend to have a higher usage compared to males. In this paper we explore this gender difference. Data: Our dataset consists of 284,674 from Norwegian adolescents attending junior high school and high school between 2014 and 2017. Methods: The econometric approach consists of applying ordered logistic regressions with usage of OTC analgesics as the dependent variable and a dichotomous gender variable as the independent variable. Control variables include variables such as frequency of physical and mental health problems and other sociodemographic variables. Results: Gender, physical and mental health problems and various sociodemographic variables are found to have a significant effect on usage of OTC analgesics. Females are predicted to use significantly more analgesics. A large proportion of the gender difference evaporates when controlling for various other determinants. Conclusion: A considerable part of the observed gender difference in OTC analgesic usage can be traced back to differences in frequency and severity of physical and mental health problems. Part of the gender difference in usage, however remains unexplained.

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Fatality after deliberate ingestion of sustained-release ibuprofen: a case report

Cited by 44 publications

References 13 publications

The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose

The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose

Soy Protein Microparticles for Enhanced Oral Ibuprofen Delivery: Preparation, Characterization, and In Vitro Release Evaluation

Gender Differences in Usage of Over-the-Counter Analgesics among Norwegian Adolescents

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